Current Analytical Chemistry - Online First

Background Tizanidine hydrochloride (TZ) is a centrally acting skeletal muscle relaxant used in the management of spasticity. Drug stability under different conditions has been described in the literature, but photolytic degradation rate and degradation products are not known. Objective This study aimed to determine the TZ photolytic degradation kinetics and explore the structures of five degradation products observed after Read More

Diabetes mellitus is a significant, chronic disease that occurs when the pancreas cannot produce sufficient insulin or the body's capacity to use insulin is hindered. Traditional herbal remedies have played an important part in health systems worldwide and are used to treat various acute and chronic illnesses with or without minimum side effects. Diabetic patients have traditionally relied on herbal treatments to manage their d Read More

Background Mercury (Hg) is a highly neurotoxic pollutant present in different environmental matrices. Herein, a simple and sensitive assay is proposed for Hg detection in environmental water samples employing polyethylene glycol monododecyl ether (PGME) stabilized silver nanoparticles (PGME-AgNPs). Methods The prepared PGME-AgNPs were characterized by absorption, scanning electron microscopy (SEM), atomic forc Read More

Objective The increasing environmental pollution from antibiotics poses a significant threat to public health, and this is a critical issue that requires immediate attention. Methods In this study, a simple and effective surface modification technique was presented using hyaluronic acid-dopamine conjugate (HA-DA) to impart anti-biofouling properties to basin-concave mesoporous carbon (BCMC). The synthesized materials were ch Read More

Aims This case-control study compared the concentrations of coenzyme Q10 in plasma and various trace elements from serum isolated from a patient with oral cancer to those of healthy people. Background Oral cancer is a severe and progressive disease related to metabolic disorders and oxidative stress challenges. Impaired in CoQ10, an essential component of the mitochondrial electron transport chain antioxidant. CoQ1 Read More

Background Coal-fired power plants, such as those located in Guizhou, are generating substantial amounts of fly ash. This fly ash is rich in lithium, a highly valuable metal utilized in numerous industrial applications. Effective extraction of these metals necessitates a thorough understanding of their characteristics within the fly ash. Methods Multiple analytical techniques were used to study fly ash's physicochemical properties. M Read More

Background Essential oil components play an important role in food flavoring industries and chemical industries. Essential oil from Pinus sylvestris (pine oil, scotch pine oil, Turpentine Oil), Leucadendron argenteum (silver fir needle oil), Impatiens balsamina (balsam fir needle oil), and Abies sibirica (siberianfirn needle oil) contains numerous active ingredients that help to develop drug preparation. Objective To compare the p Read More

Background Thalassemia syndromes are heterogeneous groups of inherited anemia. Managing these conditions often requires regular blood transfusions, which can lead to complications, such as iron overload and bone disorders. This study aimed to examine the biochemical markers of bone turnover in thalassemia patients and investigate their associations in the Iraqi cohort. Method The study involved 45 thalassemia p Read More

Background Angelica glauca (AG) (family Apiaceae) is used by tribes as a spice and to treat various diseases. Before consumption, effective measures must be used for quality control tests. This study establishes quality standards for A. glauca. The study analyses A. glauca roots for physico-chemical, pharmacognostic, phytochemical, heavy metals, pesticidal residue, microbial load, and aflatoxin. Methods The standa Read More

Background Traditional analysis techniques usually involve separation and pre-treatment steps prior to analysis, resulting in time and solvent consumption. In contrast, a potentiometric ion selective electrode is a simple, environmentally friendly, and cost-effective technique that is used as an alternative analytical technique, utilizing the efficacy of potentiometric sensors used in stability research and quality control investiga Read More

Background Nausea and vomiting are common responses to various factors like gastrointestinal disorders, motion sickness, pregnancy, medications, infections, and severe pain. Treatment includes antiemetic medications, hydration, dietary adjustments, rest, and, in severe cases, medical intervention to address underlying causes. Objective The present research aims at formulating buccal Promethazine with polym Read More

Background Nowadays, the challenge between clean water production and promoting an eco-friendly sorbent for the simultaneous fast and efficient removal of heavy metal ions is a hot topic and has attracted much attention. Objective The objective of this study was to fabricate a novel material (PATP@PET) by incorporating poly-(2-amino thiophenol; PATP) into the matrix of Saudi Arabian petroleum coke (PET) for simulta Read More

Background Detection and determination of ascorbic acid (AA) or vitamin C as a potent antioxidant substrate in commercial samples have an emerging significance. In relation to the colorimetry of ascorbic acid, the use of organometallic networks as enzyme peroxidase mimics has been reported many times, which is not cost-effective for commercialization. Therefore, this research, for the first time, examined the peroxi Read More

Background Copper, a precious metal in e-waste, presents a substantial economic opportunity. The study estimates that ~322000 tons of copper are discarded annually worldwide as e-waste. Given the significant financial value of copper, its recovery from e-waste is beneficial and crucial. This process also plays a pivotal role in waste management and recycling hazardous waste. The potential reduction in e-waste in landfills is a Read More

Jellyfish blooms have become increasingly common worldwide, driven by climate change, eutrophication, and the jellyfish’s unique life cycle. The rich protein derived from these resources notably, jellyfish collagen (JFC) and its hydrolysates (JFCH) peptides stands out as promising, sustainable alternatives to traditional collagen sources like bovine and rat tail collagen. Notably, JFC carries a reduced risk of prion and viral contami Read More

As beer malt bagasse, agro-industrial by-products have raised significant environmental and economic concerns due to their improper disposal and negative impact on process efficiency. Often regarded as waste, these by-products contribute to environmental degradation and resource inefficiency. However, when viewed as potential resources, they offer new opportunities. Beer malt bagasse shows excellent potential as Read More

Background The determination of flavonoid content in propolis is very important because these substances are assigned various biological properties present in propolis and their content is regulated by Brazilian legislation. The spectrophotometric method, based on the formation of a yellow complex between Al(III) and carbonyl and hydroxyl groups of flavonoids, is the most used to determine flavonoid content but is ti Read More

Coupled Plasma Mass Spectrometry (ICP-MS) has emerged as a powerful analytical technique for trace element analysis, finding widespread applications across diverse fields such as pharmaceuticals, food safety, and biological sciences. This technique is known for its exceptional sensitivity and capability to measure multiple elements simultaneously. Moreover, it provides critical insights into heavy metal and trace Read More

Background Elevated blood cholesterol has been established as a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Adults with hyperlipidemia have a significantly increased risk of developing cardiovascular diseases (CVD). First-line treatments for hyperlipidemia include statins, which help raise HDL-C levels in cases of severe and familial hypercholesterolemia and decrease LDL-C and TG levels. Numerous Read More

This review focuses on the application and mechanisms of peroxymonosulfate (PMS) in advanced oxidation processes (AOPs). It clarifies the significance of PMS in degrading organic pollutants, highlighting its high efficiency in treating persistent contaminants, such as antibiotics. The review details the roles and mechanisms of various catalysts, including single-atom catalysts, metal oxides, non-metal oxides and their c Read More

Background The detection and extraction of trace metal ions, particularly copper(II), are critical for environmental monitoring and industrial processes. Calixresorcinarene, with its unique cavity structure, offers excellent platforms for designing selective chemosensors and extractants. Functionalization of calixresorcinarene with azo groups can enhance their chromogenic properties, enabling both extraction and detecti Read More

The utilization of Gas Chromatography-Mass Spectrometry (GC-MS) for the detection of Volatile Organic Compounds (VOCs) as potential biomarkers in cancer diagnostics is an evolving and promising field. This review outlines current exploratory and pilot studies that lay a fundamental groundwork for future research. Due to the complexity of the fecal and respiratory volatilome, influenced by a myriad of biological and Read More

BackgroundMetoclopramide is a widely prescribed antiemetic drug. Its analysis in pharmaceutical formulations often involves procedures using high amounts of toxic chemicals.ObjectiveA method based on micellar liquid chromatography to determine metoclopramide hydrochloride in several oral dosage forms has been developed.MethodsThe drug was resolved from matrix compounds within 6 min using a C18 column Read More

Background Cocrystal engineering of Telmisartan (TEL, a poorly soluble antihypertensive agent) has been undertaken to improve its solubility for the last few years. However, apart from a few handpicked attempts, none of the attempts have been able to improve its solubility by more than 3-5 fold and augment its dissolution by more than 80%. Method Addressing these shortcomings, herein, we have designed a novel Telmisart Read More