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image of Revolutionizing Oral Cancer Care: The Therapeutic Potential of Coenzyme Q10 and Balanced Trace Metals

Abstract

Aims

This case-control study compared the concentrations of coenzyme Q10 in plasma and various trace elements from serum isolated from a patient with oral cancer to those of healthy people.

Background

Oral cancer is a severe and progressive disease related to metabolic disorders and oxidative stress challenges. Impaired in CoQ10, an essential component of the mitochondrial electron transport chain antioxidant. CoQ10, a major scavenger of free radicals, protects mitochondria against oxidative stress. Trace elements, such as Na+, Fe2+, Zn, and Ca2+, are also crucial regarding physiological functions and normal metabolic pathways, including cancer hallmarks.

Objectives

The study aimed to assess CoQ10 and trace metals in patients with oral cancer at various stages and compare them with healthy subjects. The current study deals with metabolic alterations that occur as oral cancer grows to enhance knowledge and potential therapeutic intervention paths.

Methods

Analysis of CoQ10 and trace element: HPLC-DAD Metal concentrations in serum were measured using ICP-OES). 55 oral cancer patients and 30 healthy individuals were recruited for blood collection. The patients were diagnosed as T1N1, T2N2 PT3 N1M8, and T4N. Study duration 2 months. Which includes patients' sex, age, habits, diet, physical characteristics, race, habits, and chronic illness.

Results

As cancer stages increased, CoQ10 levels continuously decreased from 0.5-1.26 mg/L from stage I to 0.6-2.8 mg/L to stage IV. Eight different trace elements, Na+, Fe2+, Zn+, and Ca2+, have levels across different stages of cancer with no discernible change. In healthy individuals, the CoQ10 level changed from 1.43 to 1.67 mg/L, showing age decline.

Conclusions

This study is the first to report a statistically significant reduction in CoQ10 levels related to the stages of oral cancer. In contrast, trace metal levels were kept almost constant. The findings conclude that the observed CoQ10-associated defects or deficiencies in oral cancer patients help to explain a potential cause of metabolic changes relevant to carcinogenesis. These insights are probably potential therapeutic targets for the manipulation of CoQ10 levels and support from supplements retention/balance essential metals, such as cancer care.

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2025-01-29
2025-05-25

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Revolutionizing Oral Cancer Care: The Therapeutic Potential of Coenzyme Q10 and Balanced Trace Metals
Bentham Science Publishers ; https://doi.org/10.2174/0115734110340661250106082808
/content/journals/cac/10.2174/0115734110340661250106082808
/content/journals/cac/10.2174/0115734110340661250106082808
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  • Article Type:     Research Article
Keywords: coenzyme Q10 (CoQ10) analysis ; and inductively coupled plasma-optical emission spectroscopy (ICP-OES) ; Oral cancer ; high-performance liquid chromatography with diode array detection (HPLC-DAD) ; trace elements

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