Skip to content
2000
image of Exploring the Pharmacological Evaluation of Indian Medicinal Herbs for Managing Diabetes

Abstract

Diabetes mellitus is a significant, chronic disease that occurs when the pancreas cannot produce sufficient insulin or the body's capacity to use insulin is hindered. Traditional herbal remedies have played an important part in health systems worldwide and are used to treat various acute and chronic illnesses with or without minimum side effects. Diabetic patients have traditionally relied on herbal treatments to manage their diabetes. In India, where the prevalence of diabetes is rising, traditional herbal treatments continue to play a crucial role in diabetes management, particularly in rural and marginalized regions with restricted access to modern healthcare. A significant number of diabetes patients in India persist in using these herbal remedies, derived from Ayurvedic and traditional methodologies, owing to their accessibility, cost-effectiveness, and negligible adverse effects. Various medicinal plants with anti-diabetic properties in India are These plants have been included in various research and publications linked to the antidiabetic properties of medicinal plants, both and . All of these plants have variable degrees of hypoglycemic and anti-hyperglycemic action. Furthermore, more research is needed to support the use of these medicinal herbs as an antidiabetic drug.

Loading

Article metrics loading...

/content/journals/cac/10.2174/0115734110343503250217080253
2025-02-26
2025-03-29
Loading full text...

Full text loading...

References

  1. Kousik D.M. Kumar B. A review on therapeutic uses of ocimum sanctum linn (tulsi) with its pharmacological actions. Int. J. Res. Ayurveda Pharm. 2012 3
    [Google Scholar]
  2. Vaishnav R. Agrawal R. Sandeep S. Medicinal value and future perspective of some therapeutically important plants from indian western region. Int. J. Pharm. Sci. Rev. Res. 2015 34 88 93
    [Google Scholar]
  3. Prakash D. Kumar P. Kumar N. Antioxidant and hypoglycaemic activity of some Indian medicinal plants. Pharmacologyonline 2009 3 513 521
    [Google Scholar]
  4. Ojewole J.A.O. Evaluation of the analgesic, anti‐inflammatory and anti‐diabetic properties of Sclerocarya birrea (A. Rich.) Hochst. stem‐bark aqueous extract in mice and rats. Phytother. Res. 2004 18 8 601 608 10.1002/ptr.1503 15476310
    [Google Scholar]
  5. Rai M. Herbal medicines in India: Retrospect and prospect. Fitoterapia 1994 65 483 491
    [Google Scholar]
  6. Ahmed A.M. History of diabetes mellitus. Saudi Med. J. 2002 23 4 373 378 11953758
    [Google Scholar]
  7. Mentreddy S.R. Medicinal plant species with potential antidiabetic properties. J. Sci. Food Agric. 2007 87 5 743 750 10.1002/jsfa.2811
    [Google Scholar]
  8. Choudhary D.K. Chaturvedi N. Singh A. Mishra A. Investigation of hypoglycemic effects, oxidative stress potential and xanthine-oxidase activity of polyphenols (gallic acid, catechin) derived from faba bean on 3T3-L1 cell line: insights into molecular docking and simulation study. Toxicol. Res. 2020 9 3 308 322 10.1093/toxres/tfaa025 32670562
    [Google Scholar]
  9. Gunjan M. Ravindran M. Jana G.K. A review on some potential traditional phytomedicine with antidiabetic properties. Int. J. Phytomed. 2011 3 448
    [Google Scholar]
  10. Bora J. Sahariah P. Patar A.K. Syiem D. Bhan S. Attenuation of diabetic hepatopathy in alloxan-induced diabetic mice by methanolic flower extract of Phlogacanthus thyrsiflorus Nees. J. Appl. Pharm. Sci. 2018 8 7 114 120 10.7324/JAPS.2018.8718
    [Google Scholar]
  11. Rege A. Chowdhary A. Evaluation of alpha-amylase and alpha-glucosidase inhibitory activities of Rhizophora mucronata. Int. J. Pharm. Sci. Res. 2014 5 2261
    [Google Scholar]
  12. Wang F. Surh J. Kaur M. Insulin degludec as an ultralong-acting basal insulin once a day: A systematic review. Diabetes Metab. Syndr. Obes. 2012 5 191 204 10.2147/DMSO.S21979 22826637
    [Google Scholar]
  13. Bailey C.J. Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989 12 8 553 564 10.2337/diacare.12.8.553 2673695
    [Google Scholar]
  14. Gupta P. Bala M. Gupta S. Dua A. Dabur R. Injeti E. Mittal A. Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs—A mechanistic revisit to understand their mode of action. Pharmacol. Res. 2016 113 Pt A 636 674 10.1016/j.phrs.2016.09.029 27697646
    [Google Scholar]
  15. Blahova J. Martiniakova M. Babikova M. Kovacova V. Mondockova V. Omelka R. Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals 2021 14 8 806 10.3390/ph14080806 34451903
    [Google Scholar]
  16. Purnell J.Q. Zinman B. Brunzell J.D. The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: Results from the diabetes control and complications trial/epidemiology of diabetes interventions and complications study (DCCT/EDIC) study. Circulation 2013 127 2 180 187 10.1161/CIRCULATIONAHA.111.077487 23212717
    [Google Scholar]
  17. Khole S. Londhe J. Ghaskadbi S. Devasagayam T. Beneficial effects of indian herbs for the treatment of diabetes, phytochemicals and human health: Pharmacological and molecular aspects.
    [Google Scholar]
  18. Arora K. Tomar P.C. Mohan V. Diabetic neuropathy: An insight on the transition from synthetic drugs to herbal therapies. J. Diabetes Metab. Disord. 2021 20 2 1773 1784 10.1007/s40200‑021‑00830‑2 34900824
    [Google Scholar]
  19. Modak M. Dixit P. Londhe J. Ghaskadbi S. Devasagayam T.P.A. Indian herbs and herbal drugs used for the treatment of diabetes. J. Clin. Biochem. Nutr. 2007 40 3 163 173 10.3164/jcbn.40.163 18398493
    [Google Scholar]
  20. Najeeb S. Zafar M.S. Khurshid Z. Zohaib S. Madathil S.A. Mali M. Almas K. Efficacy of metformin in the management of periodontitis: A systematic review and meta-analysis. Saudi Pharm. J. 2018 26 5 634 642 10.1016/j.jsps.2018.02.029 29991907
    [Google Scholar]
  21. Prince P.S.M. Menon V.P. Pari L. Hypoglycaemic activity of Syzigium cumini seeds: Effect on lipid peroxidation in alloxan diabetic rats. J. Ethnopharmacol. 1998 61 1 1 7 10.1016/S0378‑8741(98)00002‑6 9687076
    [Google Scholar]
  22. Vetrichelvan T. Jegadeesan M. Anti-diabetic activity of alcoholic extract of Aerva lanata (L.) Juss. ex Schultes in rats. J. Ethnopharmacol. 2002 80 2-3 103 107 10.1016/S0378‑8741(01)00412‑3 12007698
    [Google Scholar]
  23. Mukherjee P.K. Nema N.K. Maity N. Mukherjee K. Harwansh R.K. Phytochemical and therapeutic profile of Aloe vera. J. Nat. Rem. 2014 1 26
    [Google Scholar]
  24. Anbuselvi S. Esther A.R. Punithavathy R. Pharmakon evaluation in Momordica cymbalaria. Drug Invention Today 2019 11
    [Google Scholar]
  25. Jaiswal D. Kumar Rai P. Kumar A. Mehta S. Watal G. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J. Ethnopharmacol. 2009 123 3 392 396 10.1016/j.jep.2009.03.036 19501271
    [Google Scholar]
  26. Upadhyay R.K. Nutraceutical, pharmaceutical and therapeutic uses of Allium cepa: A review. Int. J. Green Pharm. 2016 10
    [Google Scholar]
  27. Meharban A. Evaluation of Hydro-Ethanolic Extract of Syzygium Cumini Seeds in High Fat Diet and Streptozotocin Induced Type 2 Diabetes Mellitus in Wistar Albino Rats. India Rajiv Gandhi University of Health Sciences 2021
    [Google Scholar]
  28. Kumari N. Kumar M. Chaudhary N. Zhang B. Radha D. Chandran D. Joshi S. Singh D. Dey A. Rajalingam S. Natarajan K. Muthukumar M. Mohankumar P. Sheri V. Dhumal S. Lorenzo J.M. Exploring the chemical and biological potential of Jamun ( Syzygium cumini (L.) Skeels) leaves: A comprehensive review. Chem. Biodivers. 2023 20 9 e202300479 10.1002/cbdv.202300479 37667613
    [Google Scholar]
  29. Deora N. Venkatraman K. Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies. J. Ayurveda Integr. Med. 2022 13 4 100675 10.1016/j.jaim.2022.100675 36481618
    [Google Scholar]
  30. Araya-Quintanilla F. Gutiérrez-Espinoza H. Cuyul-Vásquez I. Pavez L. Effectiveness of aloe vera in patients with type 2 diabetes mellitus and pre-diabetes: An overview of systematic reviews. Diabetes Metab. Syndr. 2021 15 6 102292 10.1016/j.dsx.2021.102292 34563809
    [Google Scholar]
  31. Adarthaiya S. Sehgal A. Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies. Phytother. Res. 2024 38 2 755 775 10.1002/ptr.8079 38015048
    [Google Scholar]
  32. Pareek A. Pant M. Gupta M.M. Kashania P. Ratan Y. Jain V. Pareek A. Chuturgoon A.A. Moringa oleifera: An updated comprehensive review of its pharmacological activities, ethnomedicinal, phytopharmaceutical formulation, clinical, phytochemical, and toxicological aspects. Int. J. Mol. Sci. 2023 24 3 2098 10.3390/ijms24032098 36768420
    [Google Scholar]
  33. Derebe D. Wubetu M. Alamirew A. Hypoglycemic and antihyperglycemic activities of 80% methanol root extract of acanthus polystachyus delile (Acanthaceae) in type 2 diabetic rats. Clin. Pharmacol. 2020 12 149 157 10.2147/CPAA.S273501 33061672
    [Google Scholar]
  34. Anyanwu G.O. Iqbal J. Khan S.U. Zaib S. Rauf K. Onyeneke C.E. Ojo O.O. Nisar-ur-Rahman Antidiabetic activities of chloroform fraction of Anthocleista vogelii Planch root bark in rats with diet- and alloxan-induced obesity-diabetes. J. Ethnopharmacol. 2019 229 293 302 10.1016/j.jep.2018.10.021 30342966
    [Google Scholar]
  35. Anandharajan R. Jaiganesh S. Shankernarayanan N.P. Viswakarma R.A. Balakrishnan A. In vitro glucose uptake activity of Aegles marmelos and Syzygium cumini by activation of Glut-4, PI3 kinase and PPARγ in L6 myotubes. Phytomedicine 2006 13 6 434 441 10.1016/j.phymed.2005.03.008 16716914
    [Google Scholar]
  36. Jaiswal D. Rai P.K. Watal G. Antidiabetic effect of Withania coagulans in experimental rats. Indian J. Clin. Biochem. 2009 24 1 88 93 10.1007/s12291‑009‑0015‑0 23105813
    [Google Scholar]
  37. Ahmed F. Urooj A. Traditional uses, medicinal properties, and phytopharmacology of Ficus racemosa : A review. Pharm. Biol. 2010 48 6 672 681 10.3109/13880200903241861 20645741
    [Google Scholar]
  38. Shrivastava N. Datar M. Saxena R. Pharmacognostic evaluation and physio-chemical analysis of Alstonia Scholaris bark. Biosci. Biotechnol. Res. Asia 2016 7 429 431
    [Google Scholar]
  39. Di Fabio G. Romanucci V. Zarrelli M. Giordano M. Zarrelli A. C-4 gem-dimethylated oleanes of Gymnema sylvestre and their pharmacological activities. Molecules 2013 18 12 14892 14919 10.3390/molecules181214892 24304585
    [Google Scholar]
  40. Gubbiveeranna V. Nagaraju S. Ethnomedicinal, phytochemical constituents and pharmacological activities of Tridax procumbens: A review. Int. J. Pharm. Pharm. Sci. 2016 8 1 7
    [Google Scholar]
  41. Acharya N. Acharya S. Shah U. Shah R. Hingorani L. A comprehensive analysis on Symplocos racemosa Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities. J. Ethnopharmacol. 2016 181 236 251 10.1016/j.jep.2016.01.043 26851499
    [Google Scholar]
  42. Jose B.E. Panneerselvam P. In vivo anti diabetic activity of ethyl acetate leaf extract of azima tetracantha lam in streptozotocin-induced diabetic mice. Res. J. Pharm. Technol. 2019 12 660 664
    [Google Scholar]
  43. Kakkar A. Verma D.R. Suryavanshi S. Dubey P. Characterization of chemical constituents of Tinospora cordifolia. Chem. Nat. Compd. 2013 49 1 177 179 10.1007/s10600‑013‑0550‑z
    [Google Scholar]
  44. Karunanidhi Sharma S.P. Kumar S. Rajput D.S. Pharmaceutical study of Trivanga Bhasma. Annals Ayurvedic Med 2019 8 3 4
    [Google Scholar]
  45. Badkhane Y. Yadav A. Sharma A.K. Raghuwanshi D. Uikey S.K. Mir F.A. Lone S.A. Murab T. Biological activities and medicinal properties. Int. J. Adv. Pharm. Sci. 2010 1
    [Google Scholar]
  46. Mahendran G. Manoj M. Murugesh E. Sathish Kumar R. Shanmughavel P. Rajendra Prasad K.J. Narmatha Bai V. In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl isolated from Swertia corymbosa. Phytomedicine 2014 21 11 1237 1248 10.1016/j.phymed.2014.06.011 25172785
    [Google Scholar]
  47. Subramanian R. Zaini Asmawi M. Sadikun A. A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata. Phytochem. Rev. 2012 11 1 39 75 10.1007/s11101‑011‑9219‑z
    [Google Scholar]
  48. Nepal A. Chakraborty M. An overview on medicinal plants of Sikkim Himalayas region with emphasis on antidiabetic: A review. J. Pharmacogn. Phytochem. 2021 10 4 215 217 10.22271/phyto.2021.v10.i4c.14148
    [Google Scholar]
  49. Deng Y. Cao M. Shi D. Yin Z. Jia R. Xu J. Wang C. Lv C. Liang X. He C. Yang Z. Zhao J. Toxicological evaluation of neem (Azadirachta indica) oil: Acute and subacute toxicity. Environ. Toxicol. Pharmacol. 2013 35 2 240 246 10.1016/j.etap.2012.12.015 23353547
    [Google Scholar]
  50. Shoba F.G. Parimala M. Debjani M. Vasanthi H.R. Nymphaea nouchali Burm. f. hydroalcoholic seed extract increases glucose consumption in 3T3-L1 adipocytes through activation of peroxisome proliferator-activated receptor gamma and insulin sensitization. J. Adv. Pharm. Technol. Res. 2015 6 4 183 189 10.4103/2231‑4040.165013 26605160
    [Google Scholar]
  51. Chi S. She G. Han D. Wang W. Liu Z. Liu B. Genus Tinospora: Ethnopharmacology, phytochemistry, and pharmacology. Evid. Based Complement. Alternat. Med. 2016 2016 1 9232593 10.1155/2016/9232593 27648105
    [Google Scholar]
  52. Mondal S. Mirdha B.R. Mahapatra S.C. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J. Physiol. Pharmacol. 2009 53 4 291 306 20509321
    [Google Scholar]
  53. Deka B. Manna P. Borah J. Talukdar N. A review on phytochemical, pharmacological attributes and therapeutic uses of Allium hookeri. Phytomedicine Plus 2022 2 100262 10.1016/j.phyplu.2022.100262
    [Google Scholar]
  54. Sharma P.C. Bhatia V. Bansal N. Sharma A. A review on Bael tree. Indian J. Nat. Prod. Resour. 2007 6 2 171 178
    [Google Scholar]
  55. Nishan M. Subramanian P. Murraya koenigii (curry leave)-A review on its potential. Int. J. Pharm. Tech. Res. 2015 7 566 572
    [Google Scholar]
  56. Safira A. Widayani P. An-Najaaty D. Mahesa Rani C.A. Septiani M. Syah Putra Y.A. Solikhah T.I. Khairullah A.R. Raharjo H.M. A review of an important plants: Annona squamosa leaf. Pharmacogn. J. 2022 14 2 456 463 10.5530/pj.2022.14.58
    [Google Scholar]
  57. Mukhtar H.M. Kalsi V. A review on medicinal properties of Zanthoxylum armatum DC. Res. J. Pharm. and Technol. 2018 11 5 2131 2138 10.5958/0974‑360X.2018.00395.5
    [Google Scholar]
  58. Bansode V.J. A review on pharmacological activities of Cinnamomum cassia Blume. Int. J. Green Pharm. 2012 6
    [Google Scholar]
  59. Dubey A. Nayak S. Goupale D. A review on phytochemical, pharmacological and toxicological studies on Neolamarckia cadamba. Der. Pharm. Let 2011 3 45 54
    [Google Scholar]
  60. Nagarkoti K. Kanyal J. Prakash O. Kumar R. Rawat D.S. Pant A.K. Ajuga L. A systematic review on chemical composition, phytopharmacological and biological potential. Curr. Bioact. Compd. 2021 17 9 e010621189843 10.2174/1573407216999210101230234
    [Google Scholar]
  61. Bisht S. Sisodia S. Anti-hyperglycemic and antidyslipidemic potential of Azadirachta indica leaf extract in STZ-induced diabetes mellitus. J Pharm Sci Res 2010 2 622 627
    [Google Scholar]
  62. Bhatt M. Gahlot M. Juyal V. Singh A. Phytochemical investigation and antidiabetic activity of Adhatoda zeylanica. Asian J. Pharm. Clin. Res. 2011 4 27 30
    [Google Scholar]
  63. Rahman F. Afroz S. Jahan S. Hosain M. Khondoker D.F. Rahman S.M. Banik J. Ahmad I. Rahmatullah M. Antihyperglycemic and antinociceptive properties of methanolic extract of whole plants of Amaranthus viridis L.(Amaranthaceae). Adv. Nat. Appl. Sci. 2012 6 1330 1335
    [Google Scholar]
  64. Chitra J. Padma K. Archana S. Alka J. In vitro comparisons of anti-diabetic activity of flavonoids and crude extracts of Azadiracta indica A Juss, Int J. Drug Dev. Res. 2013 5 47 54
    [Google Scholar]
  65. Mishra N. Haematological and hypoglycemic potential Anethum graveolens seeds extract in normal and diabetic Swiss albino mice. Vet. World 2013 6 8 502 10.5455/vetworld.2013.502‑507
    [Google Scholar]
  66. Jansirani S. Purushotham K. An assessment of in-vitro antimicrobial activity of andrographis paniculata-a screening study.
    [Google Scholar]
  67. Thakur G. Pal K. Mitra A. Mukherjee S. Basak A. Rousseau D. Some common antidiabetic plants of the Indian subcontinent. Food Rev. Int. 2010 26 4 364 385 10.1080/87559129.2010.496024
    [Google Scholar]
  68. Semwal B.C. Gupta J. Singh S. Kumar Y. Giri M. Antihyperglycemic activity of root of Berberis aristata DC in alloxan-induced diabetic rats. Int. J. Green Pharm. 2009 3
    [Google Scholar]
  69. Tam T.W. Liu R. Arnason J.T. Krantis A. Staines W.A. Haddad P.S. Foster B.C. Actions of ethnobotanically selected Cree anti-diabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3. J. Ethnopharmacol. 2009 126 1 119 126 10.1016/j.jep.2009.07.036 19665535
    [Google Scholar]
  70. Vetrichelvan T. Jegadeesan M. Devi B.A.U. Anti-diabetic activity of alcoholic extract of Celosia argentea Linn. seeds in rats. Biol. Pharm. Bull. 2002 25 4 526 528 10.1248/bpb.25.526 11995938
    [Google Scholar]
  71. Velmurugan P. Kamaraj M. Prema D. Phytochemical constituents of Cadaba trifoliata Roxb. root extract. Int. J. Phytomed. 2010 2
    [Google Scholar]
  72. Subbiah V. Nagaraja P. Narayan P. Nagendra H.G. Evaluation of pharmacological properties of Caesalpinia bonducella seed and shell extract. Pharmacogn. J. 2019 11 1 150 154 10.5530/pj.2019.1.25
    [Google Scholar]
  73. Jananie R. Priya V. Vijayalakshmi K. Phytoconstituents evaluation by GC-MS and anti-hyperglycemic activity of Cynodon dactylonon streptozotocin induced diabetes in rats. J. Chem. Pharm. Res. 2011 3 460 466
    [Google Scholar]
  74. Arumugam M. Raman M. Johnson B. Eagappan K. Dietary fiber isolate from coconut flakes–a functional food. Int. J. Pharm. Sci. Rev. Res. 2014 25 262 267
    [Google Scholar]
  75. Kavishankar G.B. Lakshmidevi N. Anti-diabetic effect of a novel N-Trisaccharide isolated from Cucumis prophetarum on streptozotocin–nicotinamide induced type 2 diabetic rats. Phytomedicine 2014 21 5 624 630 10.1016/j.phymed.2013.12.002 24462215
    [Google Scholar]
  76. Ramakrishnan G. Kothai R. Jaykar B. Rathnakumar T.V. In vitro antibacterial activity of different extracts of leaves of coldenia procumbens. Int. J. Pharm. Tech. Res. 2011 3 1000 1004
    [Google Scholar]
  77. Aloysius K.S. Sharanya K. Kini S. Milan G.R. Hegde S. Phytochemical analysis of Curculigo orchioides and its cytotoxic effect on lung adenocarcinoma cancer cell line (NCI-H522). Med. Plants Int. J. Phytomed. Relat. Ind. 2020 12 3 400 404 10.5958/0975‑6892.2020.00050.7
    [Google Scholar]
  78. Kaur N. Kishore L. Singh R. Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy. J. Ethnopharmacol. 2017 206 19 30 10.1016/j.jep.2017.05.018 28506898
    [Google Scholar]
  79. Meena A. Sinha A. Gupta M. Mangal A. Reddy G. Verma S. Padhi M. Pharmacognostic and physicochemical studies of Embelia ribes Burm. f. Fruit used in ayurvedic formulations, research. J. Pharm. Technol. 2013 6 645 648
    [Google Scholar]
  80. Pepato M.T. Mori D.M. Baviera A.M. Harami J.B. Vendramini R.C. Brunetti I.L. Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes. J. Ethnopharmacol. 2005 96 1-2 43 48 10.1016/j.jep.2004.07.029 15588649
    [Google Scholar]
  81. Arunachalam K. Parimelazhagan T. Antidiabetic activity of Ficus amplissima Smith. bark extract in streptozotocin induced diabetic rats. J. Ethnopharmacol. 2013 147 2 302 310 10.1016/j.jep.2013.03.004 23506985
    [Google Scholar]
  82. Samal P.K. Dangi J. Meena K.P. Beck N. Patel A. Maheshwari G. Evaluation of analgesic activity of leaves extracts of feronia limonia in experimental animal models. Res. J. Pharm. Technol. 2011 4 710 714
    [Google Scholar]
  83. Dhanani T. Singh R. Waman A. Patel P. Manivel P. Kumar S. Assessment of diversity amongst natural populations of Gymnema sylvestre from India and development of a validated HPLC protocol for identification and quantification of gymnemagenin. Ind. Crops Prod. 2015 77 901 909 10.1016/j.indcrop.2015.09.076
    [Google Scholar]
  84. Subramanian S. Dowlath M.J.H. Karuppannan S.K. Saravanan M S. Arunachalam K.D. Effect of solvent on the phytochemical extraction and GC-MS analysis of Gymnema sylvestre. Pharmacogn. J. 2020 12 4 749 761 10.5530/pj.2020.12.108
    [Google Scholar]
  85. Sunil Kumar K.N. Dayanand Reddy G. Mundugaru R. Rajagopal R. Alfarhan A. Kim Y.O. Na S.W. Kim H.J. Effect of Helicanthes elasticus (Desv.) Danser extracts on immune profile of Wistar albino rats. Saudi J. Biol. Sci. 2020 27 11 3003 3008 10.1016/j.sjbs.2020.08.049 33100859
    [Google Scholar]
  86. Karthikeyan R. Sundarapandian M. Antidiabetic activity of methanolic extract of Halodule uninervis in streptozotocin-induced diabetic mice. JJ. Pharm. Sci. Res. 2017 9 1864 1868
    [Google Scholar]
  87. Kesavi Durairaj Durairaj K. Phytochemical profile and medicinal potentials of Lannea Coromandelica stem. Int. J. Res. Pharm. Sci. 2020 11 3 3465 3472 10.26452/ijrps.v11i3.2490
    [Google Scholar]
  88. Kar A. Mukherjee P.K. Saha S. Bahadur S. Ahmmed S. Pandit S. Possible herb-drug interaction of Morus alba L.-a potential anti-diabetic plant from Indian traditional medicine. Indian J. Tradit. Knowledge 2015 14 4 626 631
    [Google Scholar]
  89. Gulilat H. Saini A.K. Saini R.V. The comparative analysis of Pinus roxburghii phytoconstituents found at various Asian locations as determined by GC-MS and its medicinal properties. Med. Plants Int. J. Phytomed. Relat. Ind. 2021 13 3 396 408 10.5958/0975‑6892.2021.00046.0
    [Google Scholar]
  90. Raju R. Nambi S.K. Gurusamy M. In vitro propagation of Pisonia grandis R. Br.: An indigenous vegetable and promising medicinal plant. Phytomorphology 2015 65 133 138
    [Google Scholar]
  91. Heidari H. Ahangarpour A. Junghani M. Absari R. Khoogar M. Ghaedi E. Effects of hydroalcoholic extract of Rhus coriaria seed on glucose and insulin related biomarkers, lipid profile, and hepatic enzymes in nicotinamide-streptozotocin-induced type II diabetic male mice. Res. Pharm. Sci. 2017 12 5 416 424 10.4103/1735‑5362.213987 28974980
    [Google Scholar]
  92. Archana N. Ramasamy M. Raj C.D. Pharmacological screening of ethanolic extract of Syzygium cumini seed on isolated smooth muscle strip and heart. Int. J. Pharm. Pharm. Sci. 2012 4 108 110
    [Google Scholar]
  93. Ibrahim R.M. El-Halawany A.M. Saleh D.O. Naggar E.M.B.E. El-Shabrawy A.E.R.O. El-Hawary S.S. HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities. Rev. Bras. Farmacogn. 2015 25 2 134 141 10.1016/j.bjp.2015.02.008
    [Google Scholar]
  94. Vijayalakshmi K. Selvaraj C.I. Evaluation of antidiabetic potential of sarcostemma brevistigma wight & arn. using alloxan-induced diabetic murine model. Appl. Biochem. Biotechnol. 2019 187 1 14 27 10.1007/s12010‑018‑2798‑z 29872991
    [Google Scholar]
  95. Walean M. Maliangkay H.P. Rondonuwu M. Pinontoan K.F. Maliangkay H.P. Astriani M. Phytochemical screening and biological activities of pakoba (Syzygium luzonense) stem bark ethanol extract. Biodiversitas 2020 21 6 21 10.13057/biodiv/d210606
    [Google Scholar]
  96. Malik T. Roy P. Abdulsalam F.I. Pandey D.K. Bhattacharjee A. Eruvaram N.R. Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita. Pharmacognosy Res. 2015 7 5 Suppl. 1 57 10.4103/0974‑8490.157997 26109789
    [Google Scholar]
  97. Junejo J.A. Mondal P. Verma V.K. Rudrapal M. Zaman M.K. Anti-diabetic assessment of the hydro-alcoholic leaf extracts of the plant Tetrastigma angustifolia (Roxb.) a traditionally used North-Eastern Indian vegetable. Biomed. Pharmacol. J. 2014 7 2 635 644 10.13005/bpj/535
    [Google Scholar]
  98. Walvekar M. Pol S. Deshmukh V. Modulatory effect of fenugreek loaded PLGA nanoparticles on lipofuscinogenesis in pancreas of alloxan induced diabetic mice. Int J Pharm Clin Res 2016 8 22 25
    [Google Scholar]
  99. Farook S.M. Atlee W.C. Antidiabetic and hypolipidemic potential of Tragia involucrata Linn. In streptozotocin-nicotinamide induced type II diabetic rats. Int. J. Pharm. Pharm. Sci. 2011 3 103 109
    [Google Scholar]
  100. Mishra B. Kar D.M. Maharana L. Dash S. Mishra G.P. Hypoglycemic activity of methanol fraction of Tectona grandis (Linn) bark in experimental rat models. Res. J. Pharm. Technol. 2021 14 4247 4252 10.52711/0974‑360X.2021.00737
    [Google Scholar]
  101. Roy U. Roy U. AFLP analysis of genetic diversity and phylogenetic relationships of Vigna radiata (L) Wilczek. Res. J. Pharm. Technol. 2021 14 4122 4128
    [Google Scholar]
  102. Paul T.K. Fariba M.H. Hossain M.N. Rahmatullah M. Oral glucose tolerance tests with a combination of momordica charantia fruits and trigonella foenum-graecum seeds. Research Gate 2017 6 43 52
    [Google Scholar]
  103. Venkatesan H. Karthi S. Hypoglycaemic effect of alcoholic extracts of the leaves of abroma augusta & gymnema sylvestre plants in type ii diabetes mellitus patients. Indian J. Public Health Res. Dev. 2020 11 288 294
    [Google Scholar]
  104. Mahajan S. Chauhan P. Subramani S.K. Anand A. Borole D. Goswamy H. Gbks P. Evaluation of “GSPF kwath”: A Gymnema sylvestre-containing polyherbal formulation for the treatment of human type 2 diabetes mellitus. Eur. J. Integr. Med. 2015 7 3 303 311 10.1016/j.eujim.2015.01.003
    [Google Scholar]
  105. Tiwari P. Ahmad K. Hassan Baig M. Gymnema sylvestre for diabetes: From traditional herb to future’s therapeutic. Curr. Pharm. Des. 2017 23 11 1667 1676 10.2174/1381612823666161108162048 27834124
    [Google Scholar]
  106. Shree P. Mishra P. Selvaraj C. Singh S.K. Chaube R. Garg N. Tripathi Y.B. Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) – A molecular docking study. J. Biomol. Struct. Dyn. 2022 40 1 190 203 10.1080/07391102.2020.1810778 32851919
    [Google Scholar]
  107. Raut S.B. Rege N.N. Malve H.O. Marathe P.A. Effect of combination of Phyllanthus emblica, Tinospora cordifolia, and Ocimum sanctum on spatial learning and memory in rats. J. Ayurveda Integr. Med. 2014 5 4 209 215 10.4103/0975‑9476.146564 25624694
    [Google Scholar]
  108. Gulati V. Harding I.H. Palombo E.A. Enzyme inhibitory and antioxidant activities of traditional medicinal plants: Potential application in the management of hyperglycemia. BMC Complement. Altern. Med. 2012 12 1 77 10.1186/1472‑6882‑12‑77 22713130
    [Google Scholar]
  109. Gulati V. Gulati P. Harding I.H. Palombo E.A. Exploring the anti-diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays. BMC Complement. Altern. Med. 2015 15 1 8 10.1186/s12906‑015‑0524‑8 25652009
    [Google Scholar]
  110. Mujawdiya P.K. Kapur S. Screening of antioxidant and α-glucosidase inhibitory activities of Indian medicinal plants. Curr. Enzym. Inhib. 2020 16 2 145 154 10.2174/1573408016666200414153108
    [Google Scholar]
  111. Grover J.K. Vats V. Rathi S.S. Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J. Ethnopharmacol. 2001 76 3 233 238 10.1016/S0378‑8741(01)00246‑X 11448544
    [Google Scholar]
  112. Sabu M.C. Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethnopharmacol. 2002 81 2 155 160 10.1016/S0378‑8741(02)00034‑X 12065146
    [Google Scholar]
  113. Satyanarayana T. Reddy P.D. Swarnalatha D. Mathews A.A. Hypoglycemic effect of a poly herbal extract on normal and streptozotocin induced diabetic rats. Int. J. Pharm. Pharm. Sci. 2010 2 56 57
    [Google Scholar]
  114. Ratra M. Gupta R. Comprehensive review on pharmacological profile of Alangium salvifolium: A medicinal plant. Pharm. Biosci. J. 2015 3 3 22 22
    [Google Scholar]
  115. Girish H. Ashok C. Robertcyril S. Sneha V. Swaroop S. Anand S. Babu A. Yogisha S. In vitro evaluation of selected Indian medicinal plants for antidiabetic properties. Pharmacologyonline 2010 2 648 658
    [Google Scholar]
  116. Kumar C.H. Kumar J.S. Ishaq B.M. Rani G.U. Prkash K.V. Antidiabetic activity of a polyherbal preparation. Pharmacologyonline 2010 2 780 787
    [Google Scholar]
  117. Sharma S.K. Singh A.P. Morphological, microscopical and physico-chemical investigations on the rhizomes of Cyperus rotundus Linn. Res. J. Pharm. Biol. Chem. Sci. 2011 2 798 806
    [Google Scholar]
  118. Kalekar S.A. Munshi R.P. Thatte U.M. Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? An in vitro assay of 3 Indian medicinal plants. BMC Complement. Altern. Med. 2013 13 1 257 10.1186/1472‑6882‑13‑257 24093976
    [Google Scholar]
  119. Kumar P. Mehta M. Satija S. Garg M. Enzymatic in vitro anti-diabetic activity of few traditional Indian medicinal plants. J. Biol. Sci. 2013 13 6 540 544 10.3923/jbs.2013.540.544
    [Google Scholar]
  120. Kosaraju J. Dubala A. Chinni S. Khatwal R.B. Satish Kumar M.N. Basavan D. A molecular connection of Pterocarpus marsupium, Eugenia jambolana and Gymnema sylvestre with dipeptidyl peptidase-4 in the treatment of diabetes. Pharm. Biol. 2014 52 2 268 271 10.3109/13880209.2013.823550 24074231
    [Google Scholar]
  121. Kemse N.G. Rashmi S. J. Food Sci. Technol. 2015 52 1911 1923
    [Google Scholar]
  122. Nimbekar T. Jain A. Kumar Mohanty P. Phytochemical screening and in-vitro antidiabetic activity of extracts of some Indian medicinal plants. Res. J. Pharm. Technol. 2021 14 2026 2030 10.52711/0974‑360X.2021.00359
    [Google Scholar]
/content/journals/cac/10.2174/0115734110343503250217080253
Loading
/content/journals/cac/10.2174/0115734110343503250217080253
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test