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157
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51 - 100 of 157 results
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The Expression of the LDLR, LDLRAP1, and PCSK9 Genes has Prognostic Significance in Triple-negative Breast Cancer
Available online: 20 January 2025More LessAims The purpose of this study was to investigate the prognostic significance of cholesterol uptake genes in predicting the survival of breast cancer patients. Background Cholesterol plays a crucial role in the homeostasis of tumor cells. It is known that cholesterol levels can influence important parameters of the disease, such as sensitivity to therapy, progression, and metastasis of cancer. Previous studies suggest that breast ca Read More
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Delineating the Potential Therapeutic Effects of Lobaric Acid as a Novel Strategy in the Treatment of Melanoma
Authors: Huda Abdirizak Jama, Mine Ensoy, Açelya Yılmazer and Demet Cansaran-DumanAvailable online: 20 January 2025More LessIntroduction Melanoma is one of the most dangerous and common types of cancer in humans. In order to minimize the toxicity and side effects of melanoma treatment, it is important to identify drug candidates that have strong anti-cancer activity and fewer side effects. Lobaric acid is a small molecule that has been found to have significant anti-cancer effects on various types of cancer cells. Methods The study aimed to invest Read More
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Identification of Key Genes and Pathways in Lenvatinib-resistant Hepatocellular Carcinoma using Bioinformatic Analysis and Experimental Validation
Authors: Ming Yang, ZhaoYue Wang, Riga Su, Dongbing Li and Jun ZhouAvailable online: 20 January 2025More LessBackground Resistance to lenvatinib poses a serious threat to the therapy of patients with Hepatocellular Carcinoma (HCC). The mechanism by which HCC develops resistance to lenvatinib is currently unknown. Objective The aim of this study was to identify key genes and pathways involved in lenvatinib resistance in HCC using bioinformatic analysis and experimental validation. Methods Differentially expressed genes (DEGs) Read More
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Elemene Injection Suppresses Pancreatic Cancer Progress through Regulating Cell Adhesion: A Research Based upon Network Pharmacology and Verification Test
Authors: Jiangang Zhao, Fenglin Zhang and Ping LiAvailable online: 20 January 2025More LessBackground This study investigates the potential effects of elemene injection on pancreatic cancer using network pharmacology and experimental validation. Methods GEO database were used to acquire genes which are differentially expressed between pancreatic cancer tissue and normal tissue. The vigorous energetic ingredients were identified in research and the object genes were obtained from BATMAN-TCM. The key t Read More
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The Effect of Gallic Acid on the Alleviation of the Chemotherapy-Induced Myelosuppression
Authors: Junyi Luo, Zhaoxia Zhang, Liming Jin, Zhaoying Wang, Qiuyue Sun and Dawei HeAvailable online: 20 January 2025More LessObjective This study aims to investigate the effect of Gallic Acid (GA) on the alleviation of chemotherapy-induced bone marrow suppression, with a comparison to Diyu sheng bai tablets (DYSB) and RhG-CSF. Methods A mouse model of bone marrow suppression was established in BALB/c mice using intraperitoneal injections of cyclophosphamide (CTX). All procedures were performed after obtaining ethical clearance from the in Read More
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Integrated Transcriptome and Proteome Analyses Reveal Differentially Expressed Genes and Proteins in Granulosa Cells from Female Patients with Metabolic Syndrome-associated Infertility
Authors: Fangli Dong, Wanjun Zhang, Bo Sun, Wenbin Niu, Jun Zhai, Yihong Guo and Fang WangAvailable online: 20 January 2025More LessBackground Metabolic Syndrome (MS) is a cluster of conditions that significantly increase the risk of infertility in women. Granulosa cells are crucial for ovarian folliculogenesis and fertility. Understanding molecular alterations in these cells can provide insights into MS-associated infertility. Objective This study aimed to investigate Differentially Expressed Genes (DEGs) and Proteins (DEPs) in granulosa cells from female patie Read More
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LGALS3BP: A Potential Prognostic Biomarker Influencing Antitumor Immunity in Triple-negative Breast Cancer
Authors: Anqi Hu, Shuaikang Pan, Yuan He, Xueru Wang, Dong Qian and Xiaoyang LiAvailable online: 20 January 2025More LessObjective LGALS3BP exhibits differential expression in various types of tumors. This study aimed to analyze its potential diagnostic and prognostic value in Triple-negative Breast Cancer (TNBC). Methods We conducted a comprehensive analysis of LGALS3BP's differential expression and its association with patient survival outcomes using data from public databases. To further validate these findings, Immunohistochemistry (I Read More
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Advanced Targeted Therapy for Colorectal Cancer with Lipid Nanoparticles
Authors: Pawan Kedar, Sankha Bhattacharya, Preeti Sakore and Bhupendra G. PrajapatiAvailable online: 16 January 2025More LessTargeted therapy for colorectal cancer (CRC) appears to have great potential with lipid nanoparticles (LNPs). The advances in LNP-based techniques, such as liposomes, exosomes, micelles, solid lipid nanoparticles (SLNs), nano-cubosomes, and plant-derived LNPs (PDLNPs), are explored in detail in this thorough review. Every platform provides distinct advantages: liposomes enable precise drug release and impro Read More
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Poly Lactic Co-glycolic Acid d-α-tocopheryl Polyethylene Glycol 1000 Succinate Fabricated Polyethylene Glycol Hybrid Nanoparticles of Imatinib Mesylate for the Treatment of Glioblastoma Multiforme
Authors: Sankha Bhattacharya, Prafull Shinde, Amit Page and Bhupendra G. PrajapatiAvailable online: 14 January 2025More LessAims This study aimed to develop Imatinib Mesylate (IMT)-loaded Poly Lactic-co-Glycolic Acid (PLGA)-D-α-tocopheryl polyethylene glycol succinate (TPGS)- Polyethylene glycol (PEG) hybrid nanoparticles (CSLHNPs) with optimized physicochemical properties for targeted delivery to glioblastoma multiforme. Background Glioblastoma multiforme (GBM) is the most destructive type of brain tumor with several complications. Currentl Read More
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Experimental Research Progress of mPGES-1 Inhibitor 2,5-dimethylcelecoxib in Various Diseases
Authors: Zhanfei Chen, Rong Chen, Laiping Wang, Zihao Yu, Weitong Chen, Hua Lin, Liumin Yu, Jinqiu Li, Zhonghui Chen, Jianlin Shen and Nanhong TangAvailable online: 14 January 2025More LessProstaglandin E2 (PGE2) plays a crucial role in inflammation. Non-steroidal anti-inflammatory medications are commonly utilized to alleviate pain and address inflammation by blocking the production of PGE2 and cyclooxygenase (COX). However, selective inhibition of COX can easily lead to a series of risks for cardiovascular diseases. Hence, it is imperative to discover safer and more efficient targets for reducing inflammation. Read More
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A Promising Druggable Target for Translational Therapy of Ovarian Cancer: A Molecular Profiling of Therapeutic Innovations, Extracellular Vesicle Acquired Resistance, and Signaling Pathways
Available online: 14 January 2025More LessOvarian cancer (OC) ranks as the fifth leading cause of cancer-related deaths in the United States, posing a significant threat to female health. Late-stage diagnoses, driven by elusive symptoms often masquerading as gastrointestinal issues, contribute to a concerning 70% of cases being identified in advanced stages. While early-stage OC brags a 90% cure rate, progression involving pelvic organs or extending beyond the Read More
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Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review
Available online: 14 January 2025More LessCancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment. However, its severe adverse effects, limited efficacy, and resistance to drugs undermine its potential. Growing evidence suggests that ginsenoside Rg3, a natural compound obtained from the gi Read More
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Novel Strategies for the Treatment of Lung Cancer: An In-depth Analysis of the Use of Immunotherapy, Precision Medicine, and Artificial Intelligence to Improve Prognoses
Authors: Pawan Kedar, Sankha Bhattacharya, Abhishek Kanugo and Bhupendra G. PrajapatiAvailable online: 14 January 2025More LessTherapeutic hurdles persist in the fight against lung cancer, although it is a leading cause of cancer-related deaths worldwide. Results are still not up to par, even with the best efforts of conventional medicine, thus new avenues of investigation are required. Examining how immunotherapy, precision medicine, and AI are being used to manage lung cancer, this review shows how these tools can change the game for patients Read More
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Theoretical Modeling of the Interactions of CoFe2O4-BaTiO3 Magnetoelectric Nanoparticles with Cancer and Healthy Cells
Authors: Gençay Sevim, Gizem Değer and Gülay BüyükköroğluAvailable online: 14 January 2025More LessIntroduction The effectiveness of pharmaceutical treatment methods is vital in cancer treatment. In this context, various targeted drug delivery systems are being developed to minimize or eliminate existing deficiencies and harms. This study aimed to model the interaction of MEN-based drug-targeting systems with cancer cells and determine the properties of interacting MENs. Methods Magnetoelectric Nanostructures (M Read More
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Current Perspectives of Diabetic Dyslipidemia and Treatment Modalities
By Gamze AkkusAvailable online: 13 January 2025More LessIntroduction Diabetes mellitus is associated with an increased risk of atherosclerosis related to dyslipidemia. Although the terms hyperlipidemia and Diabetes Mellitus (DM) or diabetic dyslipidemia are interrelated to each other, these two conditions have some differences. Aim This study aimed to highlight possible mechanisms of hyperlipidemia and/or dyslipidemia in diabetic patients, which can be treated with available and newer Read More
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Aptamers as a Potential Therapeutic and Screening Molecule for Oral Cancer
Available online: 10 January 2025More Less
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Design, Synthesis, Biological Evaluation and Docking Studies of 2-hydroxy-4-benzyloxy Chalcone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease
Authors: Wei Li, Jing Huang, Zhixin Chen, Dan Zhang, Lin He, Yan Guo, Lei Zhong, Chenwu Yang, Chunyan Yang, Mei Zeng, Jiang Zhu and Zhongcheng CaoAvailable online: 09 January 2025More LessBackground Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, but no drugs can cure this disease. Chalcones possess good antioxidant activity, anti-neuroinflammatory activity, neuroprotective effects, inhibitory effects on Aβ aggregation, and Aβ disaggregation ability. Therefore, chalcones are ideal lead compounds, and the discovery of novel anti-AD agent-based chalcones is necessary. Methods Read More
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Structural Modifications and Prospects of Histone Deacetylase (HDAC) Inhibitors in Cancer
Authors: Yu Chen, Jiahong Su, Sha Li, Feier Chen, Yan Zhang, Xingyue Wang, Yinping Zhang, Xiang Wang, Zijun Yuan, Siqi Ren, Xinyu He, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Shuai Deng, Jing Shen and Zhangang XiaoAvailable online: 09 January 2025More LessHistone deacetylases (HDACs) play a crucial role in the regulation of cancer progression and have emerged as key targets for antitumor therapy. Histone Deacetylase Inhibitors (HDACis) effectively suppress tumor cell proliferation, induce apoptosis, and cause cell cycle arrest, demonstrating broad-spectrum antitumor activity. This article primarily focuses on enhancing the selectivity of HDACis through structural modification u Read More
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A Review on Branched-Chain Amino Acid Aminotransferase (BCAT) Inhibitors: Current Status, Challenges and Perspectives
Authors: Xiansheng Zhang, Xinyuan Zhu, Yong Li, Yan Li, Wen Luo, Maaz Khan, Jiamin Pan, Hong Pan, Hua Xie and Guilong ZhaoAvailable online: 08 January 2025More LessBranched-chain amino acids (BCAAs) are essential amino acids for humans and play an indispensable role in many physiological and pathological processes. Branched-chain amino acid aminotransferase (BCAT) is a key enzyme that catalyzes the metabolism of BCAAs. BCAT is upregulated in many cancers and implicated in the development and progress of some other diseases, such as metabolic and neurological diseases; an Read More
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RNA Modification and Digestive Tract Tumors: A Review
Authors: Yafeng Liu, Shujun Zhang, Kaijie Liu, Xinyu Gu and Xinjun HuAvailable online: 08 January 2025More LessGastrointestinal tumors, including colorectal and liver cancer, are among the most prevalent and lethal solid tumors. These malignancies are characterized by worsening prognoses and increasing incidence rates. Traditional therapeutic approaches often prove ineffective. Recent advancements in high-throughput sequencing and sophisticated RNA modification detection technologies have uncovered numerous RN Read More
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FDA Approves Inavolisib Combo for PIK3CA-Mutated, HR+ Breast Cancer
By Jinwei ZhangAvailable online: 08 January 2025More Less
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Therapeutic Effects of Tea Polyphenols on Renal Damage Induced by High Uric Acid
Authors: Lingjuan Liu, Lanjun Shuai, Siyi He, Wei Xiang and Xiaojie HeAvailable online: 07 January 2025More LessBackground Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to abnormal purine metabolism in the human body. Uric acid deposits resulting from HUA can lead to complications such as renal damage. Currently, drugs used to treat HUA lack specificity and often come with specific toxic side effects. Objective This study aimed to investigate the ren Read More
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Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and other Phytoconstituents
Available online: 06 January 2025More LessChronic pain lasting more than three months or persisting after normal healing is a significant global health issue. In a healthcare system, it is crucial to ensure proper chronic pain management. Traditional pharmacological and non-pharmacological pain management techniques may not fully meet the requirements of physicians regarding effectiveness and safety. Therefore, researchers are exploring natural analgesics. Pl Read More
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Gold Nanoparticles and Chitosan as Innovative Compounds in Medicine and Cosmetology: A Review of Current Applications
Available online: 06 January 2025More LessThe medical and cosmetic industries have developed in recent years, and there has been a growing demand for new materials. Gold nanoparticles (Au NPs) and chitosan (CS) have been known and used for many years. Unfortunately, despite their numerous advantages and possible applications, such materials may possess certain disadvantages and limitations that constitute a problem in medical or cosmetic applica Read More
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The Interplay of Diet, Genome, Metabolome, and Gut Microbiome in Cardiovascular Disease: A Narrative Review
Authors: Manije Darooghegi Mofrad, Seoeun Ahn and Ock K. ChunAvailable online: 06 January 2025More LessIntroduction/Objective The responsiveness to dietary interventions is influenced by complex, multifactorial interactions among genetics, diet, lifestyle, gut microbiome, environmental factors, and clinical characteristics, such as the metabolic phenotype. Detailed metabolic and microbial phenotyping using large human datasets is essential for better understanding the link between diet, the gut microbiome, and host meta Read More
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An Azomethine Derivative, 1-(4-nitrophenyl)-N-phenylmethanimine (BCS2) Ameliorated 7,12-dimethylbenz(a)anthracene-induced Mammary Carcinoma through Nrf2-Keap1-HO-1 Pathway
Authors: Reetuparna Acharya, Pran Kishore Deb and Shakti Prasad PattanayakAvailable online: 06 January 2025More LessAims The aim of this study is the evaluation of an Azomethine derivative, BCS2, for its antioxidant and anti-tumor activities against mammary carcinoma through the Nrf2-Keap1-HO-1 pathway. Background The global prevalence of breast cancer is rising at an alarming rate. The facilitation of abnormal cell proliferation in mammary carcinoma occurs due to the disruption of signaling pathways that balance pro- and antioxida Read More
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Advancements in Structural Basis of Covalent Inhibitors Targeting SARS-CoV-2 Essential Proteins
Available online: 03 January 2025More LessCovalent inhibitors play a pivotal role in the development of pharmaceutical therapies, as they form stable, irreversible bonds with target biomolecules, leading to prolonged therapeutic effects and enhanced efficacy. Since covalent inhibitors first appeared in the late 1800s, the field has become innovative rapidly, and covalent inhibitors now account for around 30% of all marketed therapeutics. The severe acute resp Read More
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Enhance Anti-obesity Effect of Natural Compounds through Carrier Mediation
Authors: Mingyue Peng, Hao Wang, Zhenjing Liu, Shaoqian Wang, Haoqiang Qin, Ziyang Wang, Mingxiao Cui, Kehai Liu and Pingping LiuAvailable online: 03 January 2025More LessObesity is a global public health problem that can lead to many health complications or comorbidities. Medication alone or in combination with lifestyle changes or surgery is the main way to combat obesity and its complications. Most anti-obesity drugs are limited by their bioavailability, target-specific, and potentially toxic effects, so there is an urgent need for alternative treatments. Based on the new revelation of the p Read More
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Advances and Challenges in Molecular Docking Applied to Neglected Tropical Diseases
Available online: 03 January 2025More LessThe discovery of new drugs for neglected tropical diseases (NTDs) is challenging due to the complexity of parasite-host interactions, causing resistance and the scarcity of financial resources. However, computational techniques, particularly molecular docking, have made significant advancements. This approach allows for the virtual screening of large compound libraries against specific molecular targets in parasites Read More
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Interaction between microRNA and KRAS in Glioblastoma
Available online: 03 January 2025More LessGlioblastoma (GBM) characterized byits rapid progression and challenging prognosis, often featuring mutations in the Kirsten rat sarcoma virus (KRAS) gene, which is crucial for numerous cellular signaling mechanisms. Emerging research underscores a significant interaction between KRAS and microRNAs (miRNAs) in these cancers, with miRNAs playing key roles as both regulators and mediators within the KRAS signaling fra Read More
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The Role of Lipids in Atherosclerosis: Focus on Molecular Biology Mechanisms and Therapeutic Approaches
Authors: Mohammed A. Akram, Abdelhamid Khodja, Sarah Dalibalta and Amin F. MajdalawiehAvailable online: 03 January 2025More LessAtherosclerosis is a complex vascular disease characterized by the buildup of lipids, inflammatory cells and fibrous components in arterial walls leading to plaque formation and potential thrombotic events like myocardial infarction and strokes. Recently, there has been research on the roles of various types of lipids such as low-density lipoprotein (LDL) cholesterol, oxidized LDL (oxLDL) cholesterol and small dense LDL (sdLDL) Read More
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Oxidative Stress Biomarkers in Hypertension
Available online: 02 January 2025More LessArterial hypertension is a silent and progressive disease with deleterious vascular implications on all target organs, including the heart, the brain, the kidneys, and the eyes. Oxidative stress, defined as the overproduction of Reactive Oxygen Species (ROS) over antioxidants, is capable of deteriorating not only the normal endothelial but also the cellular function with further cardiovascular implications. Xanthine oxidase acti Read More
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Integrated in Silico and in Vitro Studies of Rutin's Potential against SARS-CoV-2 through the Inhibition of the RNA-dependent RNA Polymerase
Available online: 02 January 2025More LessIntroduction In our quest to identify potent inhibitors against SARS-CoV-2, an extensive investigation was conducted for the binding and inhibitory efficacy of Rutin against nine SARS-CoV-2 proteins. Method The first step of our analysis involved a comprehensive examination of structural similarity among the co-crystallized ligands associated with those proteins. A substantial structural similarity was observed between Ruti Read More
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Mechanochemical Synthesis of Diclofenac Conjugates with Glucosamine and Chitosan Exhibiting COX-2 Selective Ulcer Safe Anti-inflammatory Activity
Authors: Sana Afzal, Mohammad Saeed Iqbal and Abdul Haleem KhanAvailable online: 02 January 2025More LessIntroduction Non-steroidal anti-inflammatory drugs are associated with severe gastrointestinal irritation upon prolonged use, largely due to their carboxylic (-COOH) functional group. Aim To address this issue, we aimed to synthesize diclofenac conjugates with glucosamine and chitosan, converting the -COOH group into an amide (-CONH-) via a mechanochemical, environmentally friendly method. Method In this study, dic Read More
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Actinomycetes: A Source of Anticancer Metabolites
Authors: Muralidharan Kabilan, Veeramuthu Duraipandiyan, Prince Paul and Jackson AmalrajAvailable online: 23 December 2024More LessMicrobes in general, actinomycetes in particular, produce a wide range of antibiotics with various biological activities such as anticancer, antimicrobial, anti-inflammatory, antituberculosis and enzyme inhibition. Actinomycetes are filamentous gram-positive bacteria found in both terrestrial and marine environments. Currently, antibiotics such as Rifamycin, Tetracycline, Kanamycin, Neomycin, Streptomycin and Cla Read More
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An Updated Review Deciphering Apigenin Nanostructures as Promising Therapeutic Efficiency in Human Carcinomas
Authors: Fahad Khan, Mir Waqas Alam, Seema Ramniwas, Indra Rautela, Sorabh Lakhanpal and Pratibha PandeyAvailable online: 16 December 2024More LessApigenin (APG) is being investigated for its potential in treating different forms of cancer. It can regulate many cellular processes, such as cell proliferation, apoptosis, cell cycle arrest, invasion, metastasis, and autophagy, via controlling multiple cellular signaling pathways. In addition, this chemical demonstrates a significant preference for cancer cells over healthy cells. This is a crucial factor when compared to other treat Read More
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Anticancer and Cyclooxygenase Inhibitory Activity of Benzylidene Derivatives of Fenobam and its Thio Analogues
Available online: 16 December 2024More LessIntroduction A series of benzylidene derivatives of fenobam and its thio analogues (1-22) have been evaluated for their cytotoxicity against breast cancer (MCF-7, MDA-MB-231), ovarian cancer (A2780, SKOV-3) and cervical cancer (HELA) cell lines. Method These compounds (1-22) exhibited 72-83% inhibition of Erk activity against the ovarian cancer cell line (A2780). Compounds 3 and 20 showed the highest DNA damage effect i Read More
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Development and Validation of a Diagnostic Model for AKI Based on the Analysis of Ferroptosis-related Genes
Authors: Hengyue Zhu, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yangyang Guo, Yongheng Bai and Jingzong ZhouAvailable online: 22 November 2024More LessBackground Acute kidney injury (AKI) is a common renal condition associated with various factors, including pre-renal, post-renal, and renal causes, with ischemia-reperfusion being a frequent contributor leading to tubular injury. Early identification of AKI is crucial but remains challenging. Methods This study explored the molecular signature of AKI using gene microarray data from the GEO dataset, focusing on identifying f Read More
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Fibroblast Heterogeneity in Hepatocellular Carcinoma and Identification of Prognostic Markers Based on Single-cell Transcriptome Analysis
Authors: Junjun Jia, Xinyu Gu and Qingfei ChuAvailable online: 08 November 2024More LessBackground HCC is a malignant tumor with high morbidity and mortality. Fibroblasts play a key role in the tumor microenvironment (TME). However, the transcriptional regulatory mechanisms of fibroblasts remained unclear in HCC. Aim The aim of this study was to explore the complex role of fibroblasts in hepatocellular carcinoma (HCC) and to reveal their transcriptional regulatory mechanisms. Objective The goal of this study Read More
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Stimuli-Responsive Nano/Biomaterials for Smart Drug Delivery in Cardiovascular Diseases: Promises, Challenges and Outlooks
Authors: Pegah Vosoughi, Seyed Morteza Naghib and M. R. MozafariAvailable online: 07 November 2024More LessCardiovascular Diseases (CVDs) are responsible for the highest number of deaths and disabilities globally. Although numerous therapeutic options exist for treating CVDs, most traditional strategies have proven ineffective in halting or significantly slowing disease progression, often leading to unfavorable side effects. Using nanocarriers represents an innovative strategy for treating CVD, enabling the personalized delivery of m Read More
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C-Reactive Protein Biosensor for Diagnosing Infections Caused by Orthopedic Trauma
Authors: Xiancui Liu, Cunhua Wang, Honglong Fu, Xudong Li, Subash C.B. Gopinath and Sreeramanan SubramaniamAvailable online: 07 November 2024More LessIntroduction Infections linked to orthopedic trauma are common complications that place a significant strain on the healthcare system. Immediate identification of the infection and its severity is essential for providing effective treatment. Method C-reactive Protein (CRP) is a commonly used inflammatory marker in orthopedic surgery and has proven to be a valuable biomarker for diagnosing and monitoring infections. Specifi Read More
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Advances in Discovery and Design of Anti-influenza Virus Peptides
Authors: Shixin Li, Xi Xie, Shaofen Zhou and Jian HeAvailable online: 07 November 2024More LessThe influenza virus, a well-known pathogen that causes respiratory illness, remains an important global health threat because of the significant morbidity and mortality rates of people infected with the virus annually. The influenza virus undergoes frequent antigenic variation, and with the increasing frequency of resistant influenza strains against existing antiviral drugs, there is an urgent need for the development of new a Read More
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The Risk Genes SIRP5, CMC1, and ASAH1 as Potential Targets for the Diagnosis, Immunotherapy, and Treatment of Colon Adenocarcinoma by Single-Cell and Bulk RNA Sequencing Analysis
Authors: Zipeng Xu, Jiantao Gong, Weidong Hu, Chen Ge, Genxi Tong, Fengjun Cai, Zhenghai Zhu, Yihang Yuan and Chaobo ChenAvailable online: 07 November 2024More LessObjective Globally, one of the main causes of cancer-related mortality is Colon Adenocarcinoma (COAD). In this study, a new special Immune Cell Functions (ICF) risk model was constructed using single-cell and bulk RNA sequencing data to develop a new understanding and clinical applications for COAD. Methods The immune function gene sets were downloaded from a literature reference, and the COAD single-cell dataset GSE Read More
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An Innovative Telomere-associated Prognosis Model in AML: Predicting Immune Infiltration and Treatment Responsiveness
Authors: Binyang Song, Jinzhan Lou, Lijun Mu, Xiao Lu, Jian Sun and Bo TangAvailable online: 05 November 2024More LessAims To build an innovative telomere-associated scoring model to predict prognosis and treatment responsiveness in acute myeloid leukemia (AML). Background AML is a highly heterogeneous malignant hematologic disorder with a poor prognosis. While telomere maintenance is frequently observed in tumors, investigations into telomere-related genes (TRGs) in AML remain limited. Objectives This study aimed to identify pro Read More
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Pressure Ulcers and Nutrients: From Established Evidence to Gaps in Knowledge
Available online: 04 November 2024More LessPressure ulcers (PUs) are caused by continuous pressure or friction on the skin that damages tissue, especially over bony prominences. A critical factor in the development and progression of PUs is poor nutritional status, which often involves deficiencies in essential nutrients such as proteins, vitamins (A, C, D, E, K, and the B complex), and trace elements (including zinc, selenium, copper, iron, and manganese). These micronut Read More
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The Mechanism of Action of Exosomes Derived from Glioblastoma Cells
Authors: Ozal Beylerli, Ilgiz Gareev, Tatiana Ilyasova, Elmar Musaev and Vladimir ChekhoninAvailable online: 04 November 2024More LessGlioblastoma (GBM) is a highly aggressive and lethal brain tumor characterized by rapid growth, invasive behavior, and resistance to conventional therapies, such as surgery, radiotherapy, and chemotherapy. Despite these interventions, patient survival remains poor due to the tumor’s ability to recur and adapt to treatments. The function of GBM-derived exosomes (GBM-exosomes) as essential mediators in tumor growth has dra Read More
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Design, Synthesis, and Antitumor Potential of New Thiazole-contained 5-Fluoro-2-Oxindole Derivatives as Sunitinib Analogues
Available online: 04 November 2024More LessBackground Indole is considered the most promising scaffold for anticancer drug design due to its high bioavailability, unique chemical properties, and broad spectrum of pharmacological action. Objective Twelve novel thiazole-containing the 5-fluoro-1,3-dihydro-2H-indol-2-one derivatives as sunitinib analogs were designed and synthesized, and their anticancer activity was evaluated against the NCI-60 cancer cell lines. Metho Read More
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Chemical Synthesis and Enzymatic Modification of Mangostins: A Comprehensive Review on Structural Modifications for Drug Discover
Authors: Jordan Joon-Yip Lew and Yeun-Mun ChooAvailable online: 01 November 2024More LessMangosteens, a prominent component of Garcinia mangostana, have been extensively studied for their biological activities and structural modifications. Chemical methods, including cyclization reactions under acidic conditions, have yielded many derivatives, which often exhibit enhanced pharmacological properties compared to itself. Enzymatic biotransformation, such as glycosylation and oxidation mediated by Read More
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LNX1-AS2 as a Key Prognostic and Immunotherapy Response Biomarker for Lung Adenocarcinoma
Authors: Xiuxiu Wang, Guanzhong Yan, Xiaoying Zhang, Dongbing Li and Guangyi LiAvailable online: 31 October 2024More LessBackground The role of LNX1 antisense RNA 2 (LNX1-AS2) in lung adenocarcinoma (LUAD) remains unclear. Objective This study aimed to investigate the association between LNX1-AS2 and LUAD by employing bioinformatics analysis and experimental validation. Methods Statistical analysis and database interrogation were utilized to assess correlations among LNX1-AS2 expression, clinical characteristics of LUAD pat Read More
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TLR2 Activation as a Marker of Severe COVID-19 and a Potential Therapeutic Target
Authors: Xianxian Mao, Yijia Wu, Xinyi Zhang, Tian Zhou, Houda Huang, Mingui Fu and Yisong QianAvailable online: 31 October 2024More LessSARS-CoV-2-induced COVID-19 has been a serious public health problem, resulting in millions of lives lost over the previous three years. Although the direct infection caused by virus invasion is important for the pathobiology of COVID-19, the hyperinflammatory response and tissue injury are major contributors in critically ill patients. As a host sensor, toll-like receptor 2 (TLR2) recognizes multiple pathogen-associated molecula Read More
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