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image of Oxidative Stress Biomarkers in Hypertension

Abstract

Arterial hypertension is a silent and progressive disease with deleterious vascular implications on all target organs, including the heart, the brain, the kidneys, and the eyes. Oxidative stress, defined as the overproduction of Reactive Oxygen Species (ROS) over antioxidants, is capable of deteriorating not only the normal endothelial but also the cellular function with further cardiovascular implications. Xanthine oxidase activity, NADPH oxidase overexpression, and ROS production lead to hypertension and high arterial tone, culminating in end-organ damage. The inactivation of NO by superoxide reduces vasodilation and promotes peroxynitrite formation, which damages cellular components. Activation of MMPs by oxidative stress contributes to pathological neovascularization and angiogenesis. Salucin-β-induced activation of Angiotensin-II and NADPH results in vascular remodeling and fibrosis, while lipid peroxidation and PARP-1 activation further exacerbate cellular apoptosis and vascular calcification. Moreover, to reliably assess the oxidative status an emerging number of biomarkers are under investigation. Antioxidant therapy, alongside traditional antihypertensive agents such as beta-blockers and ACE inhibitors, offers the potential to mitigate oxidative stress and its detrimental effects. Additionally, polyphenols, found in plant-based foods, show promise in managing oxidative stress in hypertensive patients although this data has not been confirmed in randomized clinical trials. Understanding the intricate relationship between oxidative stress and hypertension underscores the importance of developing comprehensive therapeutic strategies to reduce cardiovascular risk and improve patient outcomes.

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/content/journals/cmc/10.2174/0109298673325682241114162014
2025-01-02
2025-04-15

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References

  1. RothG.A. MensahG.A. JohnsonC.O. AddoloratoG. AmmiratiE. BaddourL.M. BarengoN.C. BeatonA.Z. BenjaminE.J. BenzigerC.P. BonnyA. BrauerM. BrodmannM. CahillT.J. CarapetisJ. CatapanoA.L. ChughS.S. CooperL.T. CoreshJ. CriquiM. DeCleeneN. EagleK.A. Emmons-BellS. FeiginV.L. Fernández-SolàJ. FowkesG. GakidouE. GrundyS.M. HeF.J. HowardG. HuF. InkerL. KarthikeyanG. KassebaumN. KoroshetzW. LavieC. Lloyd-JonesD. LuH.S. MirijelloA. TemesgenA.M. MokdadA. MoranA.E. MuntnerP. NarulaJ. NealB. NtsekheM. Moraes de OliveiraG. OttoC. OwolabiM. PrattM. RajagopalanS. ReitsmaM. RibeiroA.L.P. RigottiN. RodgersA. SableC. ShakilS. Sliwa-HahnleK. StarkB. SundströmJ. TimpelP. TleyjehI.M. ValgimigliM. VosT. WheltonP.K. YacoubM. ZuhlkeL. MurrayC. FusterV. RothG.A. MensahG.A. JohnsonC.O. AddoloratoG. AmmiratiE. BaddourL.M. BarengoN.C. BeatonA. BenjaminE.J. BenzigerC.P. BonnyA. BrauerM. BrodmannM. CahillT.J. CarapetisJ.R. CatapanoA.L. ChughS. CooperL.T. CoreshJ. CriquiM.H. DeCleeneN.K. EagleK.A. Emmons-BellS. FeiginV.L. Fernández-SolaJ. FowkesF.G.R. GakidouE. GrundyS.M. HeF.J. HowardG. HuF. InkerL. KarthikeyanG. KassebaumN.J. KoroshetzW.J. LavieC. Lloyd-JonesD. LuH.S. MirijelloA. MisganawA.T. MokdadA.H. MoranA.E. MuntnerP. NarulaJ. NealB. NtsekheM. OliveiraG.M.M. OttoC.M. OwolabiM.O. PrattM. RajagopalanS. ReitsmaM.B. RibeiroA.L.P. RigottiN.A. RodgersA. SableC.A. ShakilS.S. SliwaK. StarkB.A. SundströmJ. TimpelP. TleyjehI.I. ValgimigliM. VosT. WheltonP.K. YacoubM. ZuhlkeL.J. Abbasi-KangevariM. AbdiA. AbediA. AboyansV. AbrhaW.A. Abu-GharbiehE. AbushoukA.I. AcharyaD. AdairT. AdebayoO.M. AdemiZ. AdvaniS.M. AfshariK. AfshinA. AgarwalG. AgasthiP. AhmadS. AhmadiS. AhmedM.B. AjiB. AkaluY. Akande-SholabiW. AkliluA. AkunnaC.J. AlahdabF. Al-EyadhyA. AlhabibK.F. AlifS.M. AlipourV. AljunidS.M. AllaF. Almasi-HashianiA. AlmustanyirS. Al-RaddadiR.M. AmegahA.K. AminiS. AminorroayaA. AmuH. AmugsiD.A. AncuceanuR. AnderliniD. AndreiT. AndreiC.L. Ansari-MoghaddamA. AntenehZ.A. AntonazzoI.C. AntonyB. AnwerR. AppiahL.T. ArablooJ. ÄrnlövJ. ArtantiK.D. AtaroZ. AusloosM. Avila-BurgosL. AwanA.T. AwokeM.A. AyeleH.T. AyzaM.A. AzariS. BD.B. BaheiraeiN. BaigA.A. BakhtiariA. BanachM. BanikP.C. BaptistaE.A. BarbozaM.A. BaruaL. BasuS. BediN. BéjotY. BennettD.A. BensenorI.M. BermanA.E. BezabihY.M. BhagavathulaA.S. BhaskarS. BhattacharyyaK. BijaniA. BikbovB. BirhanuM.M. BoloorA. BrantL.C. BrennerH. BrikoN.I. ButtZ.A. Caetano dos SantosF.L. CahillL.E. Cahuana-HurtadoL. CámeraL.A. Campos-NonatoI.R. Cantu-BritoC. CarJ. CarreroJ.J. CarvalhoF. Castañeda-OrjuelaC.A. Catalá-LópezF. CerinE. CharanJ. ChattuV.K. ChenS. ChinK.L. ChoiJ-Y.J. ChuD-T. ChungS-C. CirilloM. CoffeyS. ContiS. CostaV.M. CundiffD.K. DadrasO. DagnewB. DaiX. DamascenoA.A.M. DandonaL. DandonaR. DavletovK. De la Cruz-GóngoraV. De la HozF.P. De NeveJ-W. Denova-GutiérrezE. Derbew MollaM. DersehB.T. DesaiR. DeuschlG. DharmaratneS.D. DhimalM. DhunganaR.R. DianatinasabM. DiazD. DjalaliniaS. DokovaK. DouiriA. DuncanB.B. DuraesA.R. EaganA.W. EbtehajS. EftekhariA. EftekharzadehS. EkholuenetaleM. El NahasN. ElgendyI.Y. ElhadiM. El-JaafaryS.I. EsteghamatiS. EtissoA.E. EyawoO. FadhilI. FaraonE.J.A. FarisP.S. FarwatiM. FarzadfarF. FernandesE. Fernandez PrendesC. FerraraP. FilipI. FischerF. FloodD. FukumotoT. GadM.M. GaidhaneS. GanjiM. GargJ. GebreA.K. GebregiorgisB.G. GebregzabiherK.Z. GebremeskelG.G. GetacherL. ObsaA.G. GhajarA. GhashghaeeA. GhithN. GiampaoliS. GilaniS.A. GillP.S. GillumR.F. GlushkovaE.V. GnedovskayaE.V. GolechhaM. GonfaK.B. GoudarzianA.H. GoulartA.C. GuadamuzJ.S. GuhaA. GuoY. GuptaR. HachinskiV. Hafezi-NejadN. HaileT.G. HamadehR.R. HamidiS. HankeyG.J. HargonoA. HartonoR.K. HashemianM. HashiA. HassanS. HassenH.Y. HavmoellerR.J. HayS.I. HayatK. HeidariG. HerteliuC. HollaR. HosseiniM. HosseinzadehM. HostiucM. HostiucS. HousehM. HuangJ. HumayunA. IavicoliI. IbenemeC.U. IbitoyeS.E. IlesanmiO.S. IlicI.M. IlicM.D. IqbalU. IrvaniS.S.N. IslamS.M.S. IslamR.M. IsoH. IwagamiM. JainV. JavaheriT. JayapalS.K. JayaramS. JayawardenaR. JeemonP. JhaR.P. JonasJ.B. JonnagaddalaJ. JoukarF. JozwiakJ.J. JürissonM. KabirA. KahlonT. KalaniR. KalhorR. KamathA. KamelI. KandelH. KandelA. KarchA. KasaA.S. KatotoP.D.M.C. KayodeG.A. KhaderY.S. KhammarniaM. KhanM.S. KhanM.N. KhanM. KhanE.A. KhatabK. KibriaG.M.A. KimY.J. KimG.R. KimokotiR.W. KisaS. KisaA. KivimäkiM. KolteD. KoolivandA. KorshunovV.A. LaxminarayanaS.L.K. KoyanagiA. KrishanK. KrishnamoorthyV. Kuate DefoB. BicerB.K. KulkarniV. KumarG.A. KumarN. KurmiO.P. KusumaD. KwanG.F. La VecchiaC. LaceyB. LallukkaT. LanQ. LasradoS. LassiZ.S. LauriolaP. LawrenceW.R. LaxmaiahA. LeGrandK.E. LiM-C. LiB. LiS. LimS.S. LimL-L. LinH. LinZ. LinR-T. LiuX. LopezA.D. LorkowskiS. LotufoP.A. LugoA. MN.K. MadottoF. MahmoudiM. MajeedA. MalekzadehR. MalikA.A. MamunA.A. ManafiN. MansourniaM.A. MantovaniL.G. MartiniS. MathurM.R. MazzagliaG. MehataS. MehndirattaM.M. MeierT. MenezesR.G. MeretojaA. MestrovicT. MiazgowskiB. MiazgowskiT. MichalekI.M. MillerT.R. MirrakhimovE.M. MirzaeiH. MoazenB. MoghadaszadehM. MohammadY. MohammadD.K. MohammedS. MohammedM.A. MokhayeriY. MolokhiaM. MontasirA.A. MoradiG. MoradzadehR. MoragaP. MorawskaL. Moreno VelásquezI. MorzeJ. MubarikS. MuruetW. MusaK.I. NagarajanA.J. NaliniM. NangiaV. NaqviA.A. NarasimhaS.S. NascimentoB.R. NayakV.C. NazariJ. NazarzadehM. NegoiR.I. Neupane KandelS. NguyenH.L.T. NixonM.R. NorrvingB. NoubiapJ.J. NoutheB.E. NowakC. OdukoyaO.O. OgboF.A. OlagunjuA.T. OrruH. OrtizA. OstroffS.M. PadubidriJ.R. PalladinoR. PanaA. Panda-JonasS. ParekhU. ParkE-C. ParviziM. Pashazadeh KanF. PatelU.K. PathakM. PaudelR. PepitoV.C.F. PerianayagamA. PericoN. PhamH.Q. PilgrimT. PiradovM.A. PishgarF. PodderV. PolibinR.V. PourshamsA. PribadiD.R.A. RabieeN. RabieeM. RadfarA. RafieiA. RahimF. Rahimi-MovagharV. Ur RahmanM.H. RahmanM.A. RahmaniA.M. RakovacI. RamP. RamalingamS. RanaJ. RanasingheP. RaoS.J. RathiP. RawalL. RawasiaW.F. RawassizadehR. RemuzziG. RenzahoA.M.N. RezapourA. RiahiS.M. Roberts-ThomsonR.L. RoeverL. RohloffP. RomoliM. RoshandelG. RwegereraG.M. SaadatagahS. Saber-AyadM.M. SabourS. SaccoS. SadeghiM. Saeedi MoghaddamS. SafariS. SahebkarA. SalehiS. SalimzadehH. SamaeiM. SamyA.M. SantosI.S. Santric-MilicevicM.M. SarrafzadeganN. SarveazadA. SathishT. SawhneyM. SaylanM. SchmidtM.I. SchutteA.E. SenthilkumaranS. SepanlouS.G. ShaF. ShahabiS. ShahidI. ShaikhM.A. ShamaliM. ShamsizadehM. ShawonM.S.R. SheikhA. ShigematsuM. ShinM-J. ShinJ.I. ShiriR. ShiueI. ShuvalK. SiabaniS. SiddiqiT.J. SilvaD.A.S. SinghJ.A. MtechA.S. SkryabinV.Y. SkryabinaA.A. SoheiliA. SpurlockE.E. StockfeltL. StorteckyS. StrangesS. Suliankatchi AbdulkaderR. TadbiriH. TadesseE.G. TadesseD.B. TajdiniM. TariqujjamanM. TeklehaimanotB.F. TemsahM-H. TesemaA.K. ThakurB. ThankappanK.R. ThaparR. ThriftA.G. TimalsinaB. TonelliM. TouvierM. Tovani-PaloneM.R. TripathiA. TripathyJ.P. TruelsenT.C. TsegayG.M. TsegayeG.W. TsilimparisN. TusaB.S. TyrovolasS. UmapathiK.K. UnimB. UnnikrishnanB. UsmanM.S. VaduganathanM. ValdezP.R. VasankariT.J. VelazquezD.Z. VenketasubramanianN. VuG.T. VujcicI.S. WaheedY. WangY. WangF. WeiJ. WeintraubR.G. WeldemariamA.H. WestermanR. WinklerA.S. WiysongeC.S. WolfeC.D.A. WubishetB.L. XuG. YadollahpourA. YamagishiK. YanL.L. YandrapalliS. YanoY. YatsuyaH. YeheyisT.Y. YeshawY. YilgwanC.S. YonemotoN. YuC. YusefzadehH. ZachariahG. ZamanS.B. ZamanM.S. ZamanianM. ZandR. ZandifarA. ZarghiA. ZastrozhinM.S. ZastrozhinaA. ZhangZ-J. ZhangY. ZhangW. ZhongC. ZouZ. ZunigaY.M.H. MurrayC.J.L. FusterV. Global burden of cardiovascular diseases and risk factors, 1990–2019.J. Am. Coll. Cardiol.202076252982302110.1016/j.jacc.2020.11.01033309175
     [Google Scholar]
  2. ZoboP.C. TouréF.Y. CoulibalyI. Bitty-AndersonA.M. BoniS.P. NiangoranS. GuiéA. KouakouH. TchoungaB. CoffieP.A. EkoueviD.K. Prevalence of hypertension and other cardiovascular disease risk factors among university students from the National Polytechnic Institute of Côte d’Ivoire: A cross-sectional study.PLoS One2023181e027945210.1371/journal.pone.027945236602980
     [Google Scholar]
  3. QiuL. WangW. SaR. LiuF. Prevalence and risk factors of hypertension, diabetes, and dyslipidemia among adults in Northwest China.Int. J. Hypertens.2021202111010.1155/2021/552800733936811
     [Google Scholar]
  4. VishramJ.K.K. BorglykkeA. AndreasenA.H. JeppesenJ. IbsenH. JørgensenT. BrodaG. PalmieriL. GiampaoliS. DonfrancescoC. KeeF. ManciaG. CesanaG. KuulasmaaK. SansS. OlsenM.H. Impact of age on the importance of systolic and diastolic blood pressures for stroke risk: The MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project.Hypertension20126051117112310.1161/HYPERTENSIONAHA.112.20140023006731
     [Google Scholar]
  5. AbrahamowiczA.A. EbingerJ. WheltonS.P. Commodore-MensahY. YangE. Racial and ethnic disparities in hypertension: Barriers and opportunities to improve blood pressure control.Curr. Cardiol. Rep.2023251172710.1007/s11886‑022‑01826‑x36622491
     [Google Scholar]
  6. CaoX. ZhaoZ. KangY. TianY. SongY. WangL. ZhangL. WangX. ChenZ. ZhengC. TianL. YinP. FangY. ZhangM. HeY. ZhangZ. WeintraubW.S. ZhouM. WangZ. CaoX. ZhaoZ. KangY. TianY. SongY. WangL. ZhangL. WangX. ChenZ. ZhengC. TianL. ChenL. CaiJ. HuZ. ZhouH. GuR. HuangY. YinP. FangY. ZhangM. HeY. ZhangZ. WeintraubW.S. ZhouM. WangZ. The burden of cardiovascular disease attributable to high systolic blood pressure across China, 2005–18: A population-based study.Lancet Public Health2022712e1027e104010.1016/S2468‑2667(22)00232‑836462514
     [Google Scholar]
  7. LipG.Y.H. CocaA. KahanT. BorianiG. ManolisA.S. OlsenM.H. OtoA. PotparaT.S. SteffelJ. MarínF. de Oliveira FigueiredoM.J. de SimoneG. TzouW.S. ChiangC.E. WilliamsB. Hypertension and cardiac arrhythmias: Executive summary of a consensus document from the european heart rhythm association (EHRA) and ESC council on hypertension, endorsed by the heart rhythm society (HRS), Asia-pacific heart rhythm society (APHRS) and sociedad latinoamericana de estimulación cardíaca y electrofisiología (SOLEACE).Eur. Heart J. Cardiovasc. Pharmacother.20173423525010.1093/ehjcvp/pvx01928541499
     [Google Scholar]
  8. CanavanM. O’DonnellM.J. Hypertension and cognitive impairment: A review of mechanisms and key concepts.Front. Neurol.20221382113510.3389/fneur.2022.82113535185772
     [Google Scholar]
  9. HarrisonD.G. CoffmanT.M. WilcoxC.S. Pathophysiology of hypertension.Circ. Res.2021128784786310.1161/CIRCRESAHA.121.31808233793328
     [Google Scholar]
  10. SunB. LuL. GaoY. YuB. ChenS. TongA. WuX. MaoJ. WangX. ZhaoZ. ZhangW. NieM. High prevalence of hypertension and target organ damage in patients with 11β-hydroxylase deficiency.Clin. Endocrinol. (Oxf.)202296565766510.1111/cen.1467735067946
     [Google Scholar]
  11. BornsteinA.B. RaoS.S. MarwahaK. Left Ventricular hypertrophy.Treasure Island (FL)StatPearls Publishing2024
     [Google Scholar]
  12. CrowleyS.D. GurleyS.B. HerreraM.J. RuizP. GriffithsR. KumarA.P. KimH.S. SmithiesO. LeT.H. CoffmanT.M. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.Proc. Natl. Acad. Sci. USA200610347179851799010.1073/pnas.060554510317090678
     [Google Scholar]
  13. SlivnickJ. LampertB.C. Hypertension and Heart Failure.Heart Fail. Clin.201915453154110.1016/j.hfc.2019.06.00731472888
     [Google Scholar]
  14. StantonT. DunnF.G. Hypertension, left ventricular hypertrophy, and myocardial ischemia.Med. Clin. North Am.20171011294110.1016/j.mcna.2016.08.00327884233
     [Google Scholar]
  15. FeiginV.L. StarkB.A. JohnsonC.O. RothG.A. BisignanoC. AbadyG.G. AbbasifardM. Abbasi-KangevariM. Abd-AllahF. AbediV. AbualhasanA. Abu-RmeilehN.M.E. AbushoukA.I. AdebayoO.M. AgarwalG. AgasthiP. AhinkorahB.O. AhmadS. AhmadiS. Ahmed SalihY. AjiB. AkbarpourS. AkinyemiR.O. Al HamadH. AlahdabF. AlifS.M. AlipourV. AljunidS.M. AlmustanyirS. Al-RaddadiR.M. Al-Shahi SalmanR. Alvis-GuzmanN. AncuceanuR. AnderliniD. AndersonJ.A. AnsarA. AntonazzoI.C. ArablooJ. ÄrnlövJ. ArtantiK.D. AryanZ. AsgariS. AshrafT. AtharM. AtreyaA. AusloosM. BaigA.A. BaltatuO.C. BanachM. BarbozaM.A. Barker-ColloS.L. BärnighausenT.W. BaroneM.T.U. BasuS. BazmandeganG. BeghiE. BeheshtiM. BéjotY. BellA.W. BennettD.A. BensenorI.M. BezabheW.M. BezabihY.M. BhagavathulaA.S. BhardwajP. BhattacharyyaK. BijaniA. BikbovB. BirhanuM.M. BoloorA. BonnyA. BrauerM. BrennerH. BryazkaD. ButtZ.A. Caetano dos SantosF.L. Campos-NonatoI.R. Cantu-BritoC. CarreroJ.J. Castañeda-OrjuelaC.A. CatapanoA.L. ChakrabortyP.A. CharanJ. ChoudhariS.G. ChowdhuryE.K. ChuD-T. ChungS-C. ColozzaD. CostaV.M. CostanzoS. CriquiM.H. DadrasO. DagnewB. DaiX. DalalK. DamascenoA.A.M. D’AmicoE. DandonaL. DandonaR. Darega GelaJ. DavletovK. De la Cruz-GóngoraV. DesaiR. DhamnetiyaD. DharmaratneS.D. DhimalM.L. DhimalM. DiazD. DichgansM. DokovaK. DoshiR. DouiriA. DuncanB.B. EftekharzadehS. EkholuenetaleM. El NahasN. ElgendyI.Y. ElhadiM. El-JaafaryS.I. EndresM. EndriesA.Y. ErkuD.A. FaraonE.J.A. FarooqueU. FarzadfarF. FerozeA.H. FilipI. FischerF. FloodD. GadM.M. GaidhaneS. Ghanei GheshlaghR. GhashghaeeA. GhithN. GhozaliG. GhozyS. GialluisiA. GiampaoliS. GilaniS.A. GillP.S. GnedovskayaE.V. GolechhaM. GoulartA.C. GuoY. GuptaR. GuptaV.B. GuptaV.K. GyanwaliP. Hafezi-NejadN. HamidiS. HanifA. HankeyG.J. HargonoA. HashiA. HassanT.S. HassenH.Y. HavmoellerR.J. HayS.I. HayatK. HegazyM.I. HerteliuC. HollaR. HostiucS. HousehM. HuangJ. HumayunA. HwangB-F. IacovielloL. IavicoliI. IbitoyeS.E. IlesanmiO.S. IlicI.M. IlicM.D. IqbalU. IrvaniS.S.N. IslamS.M.S. IsmailN.E. IsoH. IsolaG. IwagamiM. JacobL. JainV. JangS-I. JayapalS.K. JayaramS. JayawardenaR. JeemonP. JhaR.P. JohnsonW.D. JonasJ.B. JosephN. JozwiakJ.J. JürissonM. KalaniR. KalhorR. KalkondeY. KamathA. KamiabZ. KanchanT. KandelH. KarchA. KatotoP.D.M.C. KayodeG.A. KeshavarzP. KhaderY.S. KhanE.A. KhanI.A. KhanM. KhanM.A.B. KhatibM.N. KhubchandaniJ. KimG.R. KimM.S. KimY.J. KisaA. KisaS. KivimäkiM. KolteD. KoolivandA. Koulmane LaxminarayanaS.L. KoyanagiA. KrishanK. KrishnamoorthyV. KrishnamurthiR.V. KumarG.A. KusumaD. La VecchiaC. LaceyB. LakH.M. LallukkaT. LasradoS. LavadosP.M. LeonardiM. LiB. LiS. LinH. LinR-T. LiuX. LoW.D. LorkowskiS. LucchettiG. Lutzky SauteR. Magdy Abd El RazekH. MagnaniF.G. MahajanP.B. MajeedA. MakkiA. MalekzadehR. MalikA.A. ManafiN. MansourniaM.A. MantovaniL.G. MartiniS. MazzagliaG. MehndirattaM.M. MenezesR.G. MeretojaA. MershaA.G. Miao JonassonJ. MiazgowskiB. MiazgowskiT. MichalekI.M. MirrakhimovE.M. MohammadY. Mohammadian-HafshejaniA. MohammedS. MokdadA.H. MokhayeriY. MolokhiaM. MoniM.A. MontasirA.A. MoradzadehR. MorawskaL. MorzeJ. MuruetW. MusaK.I. NagarajanA.J. NaghaviM. Narasimha SwamyS. NascimentoB.R. NegoiR.I. Neupane KandelS. NguyenT.H. NorrvingB. NoubiapJ.J. NwatahV.E. OanceaB. OdukoyaO.O. OlagunjuA.T. OrruH. OwolabiM.O. PadubidriJ.R. PanaA. ParekhT. ParkE-C. Pashazadeh KanF. PathakM. PeresM.F.P. PerianayagamA. PhamT-M. PiradovM.A. PodderV. PolinderS. PostmaM.J. PourshamsA. RadfarA. RafieiA. RaggiA. RahimF. Rahimi-MovagharV. RahmanM. RahmanM.A. RahmaniA.M. RajaiN. RanasingheP. RaoC.R. RaoS.J. RathiP. RawafD.L. RawafS. ReitsmaM.B. RenjithV. RenzahoA.M.N. RezapourA. RodriguezJ.A.B. RoeverL. RomoliM. RynkiewiczA. SaccoS. SadeghiM. Saeedi MoghaddamS. SahebkarA. Saif-Ur-RahmanK.M. SalahR. SamaeiM. SamyA.M. SantosI.S. Santric-MilicevicM.M. SarrafzadeganN. SathianB. SattinD. SchiavolinS. SchlaichM.P. SchmidtM.I. SchutteA.E. SepanlouS.G. SeylaniA. ShaF. ShahabiS. ShaikhM.A. ShannawazM. ShawonM.S.R. SheikhA. SheikhbahaeiS. ShibuyaK. SiabaniS. SilvaD.A.S. SinghJ.A. SinghJ.K. SkryabinV.Y. SkryabinaA.A. SobaihB.H. StorteckyS. StrangesS. TadesseE.G. TariganI.U. TemsahM-H. TeuschlY. ThriftA.G. TonelliM. Tovani-PaloneM.R. TranB.X. TripathiM. TsegayeG.W. UllahA. UnimB. UnnikrishnanB. VakilianA. Valadan TahbazS. VasankariT.J. VenketasubramanianN. VervoortD. VoB. VoloviciV. VosoughiK. VuG.T. VuL.G. WafaH.A. WaheedY. WangY. WijeratneT. WinklerA.S. WolfeC.D.A. WoodwardM. WuJ.H. Wulf HansonS. XuX. YadavL. YadollahpourA. Yahyazadeh JabbariS.H. YamagishiK. YatsuyaH. YonemotoN. YuC. YunusaI. ZamanM.S. ZamanS.B. ZamanianM. ZandR. ZandifarA. ZastrozhinM.S. ZastrozhinaA. ZhangY. ZhangZ-J. ZhongC. ZunigaY.M.H. MurrayC.J.L. Global, regional, and national burden of stroke and its risk factors, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019.Lancet Neurol.2021201079582010.1016/S1474‑4422(21)00252‑034487721
     [Google Scholar]
  16. WebbA.J.S. WerringD.J. New insights into cerebrovascular pathophysiology and hypertension.Stroke20225341054106410.1161/STROKEAHA.121.03585035255709
     [Google Scholar]
  17. PughD. GallacherP.J. DhaunN. Management of hypertension in chronic kidney disease.Drugs201979436537910.1007/s40265‑019‑1064‑130758803
     [Google Scholar]
  18. HamrahianS.M. FalknerB. Hypertension in chronic kidney disease.Adv. Exp. Med. Biol.201695630732510.1007/5584_2016_8427873228
     [Google Scholar]
  19. ModiP. ArsiwallaT. Hypertensive Retinopathy.Treasure Island (FL)StatPearls Publishing2024
     [Google Scholar]
  20. GutteridgeJ.M.C. HalliwellB. Free radicals and antioxidants in the year 2000. A historical look to the future.Ann. N. Y. Acad. Sci.2000899113614710.1111/j.1749‑6632.2000.tb06182.x10863535
     [Google Scholar]
  21. AntonopoulosA.S. GoliopoulouA. OikonomouE. TsalamandrisS. PapamikroulisG.A. LazarosG. TsiamisE. LatsiosG. BriliS. PapaioannouS. GennimataV. TousoulisD. Redox state in atrial fibrillation pathogenesis and relevant therapeutic approaches.Curr. Med. Chem.201926576577910.2174/092986732466617071813040828721830
     [Google Scholar]
  22. PizzinoG. IrreraN. CucinottaM. PallioG. ManninoF. ArcoraciV. SquadritoF. AltavillaD. BittoA. Oxidative stress: Harms and benefits for human health.Oxid. Med. Cell. Longev.201720171841676310.1155/2017/841676328819546
     [Google Scholar]
  23. SiesH. Oxidative stress: Oxidants and antioxidants.Exp. Physiol.199782229129510.1113/expphysiol.1997.sp0040249129943
     [Google Scholar]
  24. FarrisP.K. ValacchiG. Ultraviolet light protection: Is it really enough?Antioxidants2022118148410.3390/antiox1108148436009203
     [Google Scholar]
  25. DanforthJ.M. ProvencherL. GoodarziA.A. Chromatin and the cellular response to particle radiation-induced oxidative and clustered DNA damage.Front. Cell Dev. Biol.20221091044010.3389/fcell.2022.91044035912116
     [Google Scholar]
  26. WangV.A. KoutrakisP. LiL. LiuM. VieiraC.L.Z. CoullB.A. MaherE.F. KangC.M. GarshickE. Particle radioactivity from radon decay products and reduced pulmonary function among chronic obstructive pulmonary disease patients.Environ. Res.2023216Pt 111449210.1016/j.envres.2022.11449236209792
     [Google Scholar]
  27. SuleR.O. CondonL. GomesA.V. A common feature of pesticides: Oxidative stress—the role of oxidative stress in pesticide-induced toxicity.Oxid. Med. Cell. Longev.2022202213110.1155/2022/556375935096268
     [Google Scholar]
  28. ChalansonnetM. CarabinN. BoucardS. CosnierF. NungeH. GagnaireF. Study of the potential oxidative stress induced by six solvents in the rat brain.Neurotoxicology201335718310.1016/j.neuro.2012.12.00223270871
     [Google Scholar]
  29. ChukwukaA.V. JeromeF.C. HassanA. EbonwuB. AdeogunA.O. Redox-active metals and oxidative stress-mediated myopathies in Callinectes amnicola, blue crab populations from impacted sites of the Lagos Lagoon: Inferences for adverse ecological outcomes.Environ. Sci. Pollut. Res. Int.2023305010856510858110.1007/s11356‑023‑29912‑937752391
     [Google Scholar]
  30. TsermpiniE.E. Plemenitaš IlješA. DolžanV. Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder: A systematic review.Antioxidants2022117137410.3390/antiox1107137435883865
     [Google Scholar]
  31. KawamuraT. MuraokaI. Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint.Antioxidants20187911910.3390/antiox709011930189660
     [Google Scholar]
  32. LassègueB. ClempusR.E. Vascular NAD(P)H oxidases: Specific features, expression, and regulation.Am. J. Physiol. Regul. Integr. Comp. Physiol.20032852R277R29710.1152/ajpregu.00758.200212855411
     [Google Scholar]
  33. FeairhellerD.L. BrownM.D. ParkJ.Y. BrinkleyT. BasuS. HagbergJ.M. FerrellR. Fenty-StewartN.M. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension.Med. Sci. Sports Exerc.20094171421142810.1249/MSS.0b013e318199cee819516159
     [Google Scholar]
  34. LaaksoJ.T. TeräväinenT.L. MartelinE. VaskonenT. LapattoR. Renal xanthine oxidoreductase activity during development of hypertension in spontaneously hypertensive rats.J. Hypertens.20042271333134010.1097/01.hjh.0000125441.28861.9f15201549
     [Google Scholar]
  35. PinheiroL.C. Oliveira-PaulaG.H. Sources and effects of oxidative stress in hypertension.Curr. Hypertens. Rev.202016316618010.2174/18756506OTg2CNjUuTcVY31146669
     [Google Scholar]
  36. TsalamandrisS. VogiatziG. AntonopoulosA.S. TousoulisD. The Role of Oxidative Stress.Coronary Artery Disease. TousoulisD. Cambridge, MassachusettsAcademic Press20189510010.1016/B978‑0‑12‑811908‑2.00006‑4
     [Google Scholar]
  37. DeshpandeO.A. MohiuddinS.S. Biochemistry, Oxidative Phosphorylation.Treasure Island (FL)StatPearls Publishing2024
     [Google Scholar]
  38. HalliwellB. AdhikaryA. DingfelderM. DizdarogluM. Hydroxyl radical is a significant player in oxidative DNA damage in vivo.Chem. Soc. Rev.202150158355836010.1039/D1CS00044F34128512
     [Google Scholar]
  39. RadiR. Peroxynitrite, a stealthy biological oxidant.J. Biol. Chem.201328837264642647210.1074/jbc.R113.47293623861390
     [Google Scholar]
  40. Janaszak-JasieckaA. PłoskaA. WierońskaJ.M. DobruckiL.W. KalinowskiL. Endothelial dysfunction due to eNOS uncoupling: Molecular mechanisms as potential therapeutic targets.Cell. Mol. Biol. Lett.20232812110.1186/s11658‑023‑00423‑236890458
     [Google Scholar]
  41. BeloV.A. GuimarãesD.A. CastroM.M. Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension.J. Vasc. Res.201552422123110.1159/00044162126731549
     [Google Scholar]
  42. ValenteF.M. de AndradeD.O. Cosenso-MartinL.N. CesarinoC.B. GuimarãesS.M. GuimarãesV.B. LacchiniR. Tanus-SantosJ.E. Yugar-ToledoJ.C. Vilela-MartinJ.F. Plasma levels of matrix metalloproteinase-9 are elevated in individuals with hypertensive crisis.BMC Cardiovasc. Disord.202020113210.1186/s12872‑020‑01412‑532164582
     [Google Scholar]
  43. RenX.S. LingL. ZhouB. HanY. ZhouY.B. ChenQ. LiY.H. KangY.M. ZhuG.Q. Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats.Sci. Rep.2017714325910.1038/srep4325928230187
     [Google Scholar]
  44. WangC. XuW. AnJ. LiangM. LiY. ZhangF. TongQ. HuangK. Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2.Nat. Commun.2019101120310.1038/s41467‑019‑09174‑130867423
     [Google Scholar]
  45. BartlettD.E. MillerR.B. ThiesfeldtS. LakhaniH.V. ShapiroJ.I. SodhiK. The role of Na/K-ATPase signaling in oxidative stress related to aging: Implications in obesity and cardiovascular disease.Int. J. Mol. Sci.2018197213910.3390/ijms1907213930041449
     [Google Scholar]
  46. BarreraG. PizzimentiS. DagaM. DianzaniC. ArcaroA. CetrangoloG.P. GiordanoG. CucciM.A. GrafM. GentileF. Lipid peroxidation-derived aldehydes, 4-hydroxynonenal and malondialdehyde in aging-related disorders.Antioxidants20187810210.3390/antiox708010230061536
     [Google Scholar]
  47. PiX. XieL. PattersonC. Emerging roles of vascular endothelium in metabolic homeostasis.Circ. Res.2018123447749410.1161/CIRCRESAHA.118.31323730355249
     [Google Scholar]
  48. FountoulakisP. OikonomouE. LazarosG. TousoulisD. Endothelial function.Coronary Artery Disease. TousoulisD. Cambridge, massachusettsAcademic Press2018133010.1016/B978‑0‑12‑811908‑2.00002‑7
     [Google Scholar]
  49. DriE. LampasE. LazarosG. LazarouE. TheofilisP. TsioufisC. TousoulisD. Inflammatory mediators of endothelial dysfunction.Life (Basel)2023136142010.3390/life1306142037374202
     [Google Scholar]
  50. AroraD. JainP. SinghN. KaurH. BhatlaS.C. Mechanisms of nitric oxide crosstalk with reactive oxygen species scavenging enzymes during abiotic stress tolerance in plants.Free Radic. Res.201650329130310.3109/10715762.2015.111847326554526
     [Google Scholar]
  51. PatrickD.M. Van BeusecumJ.P. KiraboA. The role of inflammation in hypertension: Novel concepts.Curr. Opin. Physiol.202119929810.1016/j.cophys.2020.09.01633073072
     [Google Scholar]
  52. WuJ. SalehM.A. KiraboA. ItaniH.A. MontanielK.R.C. XiaoL. ChenW. MernaughR.L. CaiH. BernsteinK.E. GoronzyJ.J. WeyandC.M. CurciJ.A. BarbaroN.R. MorenoH. DaviesS.S. RobertsL.J.II MadhurM.S. HarrisonD.G. Immune activation caused by vascular oxidation promotes fibrosis and hypertension.J. Clin. Invest.20151261506710.1172/JCI8076126595812
     [Google Scholar]
  53. AgitaA. AlsagaffM.T. Inflammation, immunity, and hypertension.Acta Med. Indones.201749215816528790231
     [Google Scholar]
  54. SmallH.Y. MigliarinoS. Czesnikiewicz-GuzikM. GuzikT.J. Hypertension: Focus on autoimmunity and oxidative stress.Free Radic. Biol. Med.201812510411510.1016/j.freeradbiomed.2018.05.08529857140
     [Google Scholar]
  55. LoperenaR. HarrisonD.G. Oxidative stress and hypertensive diseases.Med. Clin. North Am.2017101116919310.1016/j.mcna.2016.08.00427884227
     [Google Scholar]
  56. ZhangZ. ZhaoL. ZhouX. MengX. ZhouX. Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets.Front. Immunol.202313109872510.3389/fimmu.2022.109872536703963
     [Google Scholar]
  57. RennaN.F. de Las HerasN. MiatelloR.M. Pathophysiology of vascular remodeling in hypertension.Int. J. Hypertens.2013201380835323970958
     [Google Scholar]
  58. MassaroM. ScodittiE. CarluccioM.A. De CaterinaR. Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?Vascul. Pharmacol.2019116455010.1016/j.vph.2019.03.00430946986
     [Google Scholar]
  59. BeloV.A. ParenteJ.M. Tanus-SantosJ.E. CastroM.M. Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.Biochem. Pharmacol.2016118505810.1016/j.bcp.2016.08.01227531060
     [Google Scholar]
  60. VirdisA. NevesM.F. AmiriF. VielE. TouyzR.M. SchiffrinE.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress.Hypertension200240450451010.1161/01.HYP.0000034738.79310.0612364354
     [Google Scholar]
  61. CejasP. CasadoE. Belda-IniestaC. CastroJ.D. EspinosaE. RedondoA. SerenoM. García-CabezasM.Á. VaraJ.A.F. Domínguez-CáceresA. PeronaR. González-BarónM. Implications of oxidative stress and cell membrane lipid peroxidation in human cancer (Spain).Cancer Causes Control200415770771910.1023/B:CACO.0000036189.61607.5215280629
     [Google Scholar]
  62. BattyM. BennettM.R. YuE. The role of oxidative stress in atherosclerosis.Cells20221123384310.3390/cells1123384336497101
     [Google Scholar]
  63. JomovaK. RaptovaR. AlomarS.Y. AlwaselS.H. NepovimovaE. KucaK. ValkoM. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging.Arch. Toxicol.202397102499257410.1007/s00204‑023‑03562‑937597078
     [Google Scholar]
  64. SenonerT. DichtlW. Oxidative stress in cardiovascular diseases: Still a therapeutic target?Nutrients2019119209010.3390/nu1109209031487802
     [Google Scholar]
  65. GriendlingK.K. CamargoL.L. RiosF.J. Alves-LopesR. MontezanoA.C. TouyzR.M. Oxidative stress and hypertension.Circ. Res.20211287993102010.1161/CIRCRESAHA.121.31806333793335
     [Google Scholar]
  66. van der PolA. van GilstW.H. VoorsA.A. van der MeerP. Treating oxidative stress in heart failure: Past, present and future.Eur. J. Heart Fail.201921442543510.1002/ejhf.132030338885
     [Google Scholar]
  67. KurianG.A. RajagopalR. VedanthamS. RajeshM. The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: Revisited.Oxid. Med. Cell. Longev.201620161165645010.1155/2016/165645027313825
     [Google Scholar]
  68. VassalleM. LinC.I. Calcium overload and cardiac function.J. Biomed. Sci.200411554256510.1007/BF0225611915316129
     [Google Scholar]
  69. HadeishiH. MaybergM.R. SetoM. Local application of calcium antagonists inhibits intimal hyperplasia after arterial injury.Neurosurgery19943411141218121548
     [Google Scholar]
  70. PoznyakA.V. NikiforovN.G. MarkinA.M. KashirskikhD.A. MyasoedovaV.A. GerasimovaE.V. OrekhovA.N. Overview of OxLDL and its impact on cardiovascular health: Focus on atherosclerosis.Front. Pharmacol.20211161378010.3389/fphar.2020.61378033510639
     [Google Scholar]
  71. FolinoA. LosanoG. RastaldoR. Balance of nitric oxide and reactive oxygen species in myocardial reperfusion injury and protection.J. Cardiovasc. Pharmacol.201362656757510.1097/FJC.0b013e3182a50c4523921313
     [Google Scholar]
  72. TousoulisD. KampoliA.M. PapageorgiouC.W. StefanadisC. StefanadisC. The role of nitric oxide on endothelial function.Curr. Vasc. Pharmacol.201210141810.2174/15701611279882976022112350
     [Google Scholar]
  73. MacLeodK.T. Recent advances in understanding cardiac contractility in health and disease.F1000 Res.20165177010.12688/f1000research.8661.127508064
     [Google Scholar]
  74. BabaS.P. BhatnagarA. Role of thiols in oxidative stress.Curr. Opin. Toxicol.2018713313910.1016/j.cotox.2018.03.00530338308
     [Google Scholar]
  75. MatsumotoA. ComatasK.E. LiuL. StamlerJ.S. Screening for nitric oxide-dependent protein-protein interactions.Science2003301563365766110.1126/science.107931912893946
     [Google Scholar]
  76. MongirdienėA. SkrodenisL. VaroneckaitėL. MierkytėG. GerulisJ. Reactive oxygen species induced pathways in heart failure pathogenesis and potential therapeutic strategies.Biomedicines202210360210.3390/biomedicines1003060235327404
     [Google Scholar]
  77. QueliconiB.B. WojtovichA.P. NadtochiyS.M. KowaltowskiA.J. BrookesP.S. Redox regulation of the mitochondrial KATP channel in cardioprotection.Biochim. Biophys. Acta Mol. Cell Res.2011181371309131510.1016/j.bbamcr.2010.11.00521094666
     [Google Scholar]
  78. SkyschallyA. SchulzR. GresP. KorthH.G. HeuschG. Attenuation of ischemic preconditioning in pigs by scavenging of free oxyradicals with ascorbic acid.Am. J. Physiol. Heart Circ. Physiol.20032842H698H70310.1152/ajpheart.00693.200212388272
     [Google Scholar]
  79. MorisD. SpartalisM. SpartalisE. KarachaliouG.S. KaraolanisG.I. TsourouflisG. TsilimigrasD.I. TzatzakiE. TheocharisS. The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox.Ann. Transl. Med.201751632610.21037/atm.2017.06.2728861423
     [Google Scholar]
  80. YangS. LiW. Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies.Brain Circ.20162415316310.4103/2394‑8108.19527930276293
     [Google Scholar]
  81. CarcyR. CougnonM. PoetM. DurandyM. SicardA. CounillonL. BlondeauN. HauetT. TaucM. PisaniD.F. Targeting oxidative stress, a crucial challenge in renal transplantation outcome.Free Radic. Biol. Med.202116925827010.1016/j.freeradbiomed.2021.04.02333892115
     [Google Scholar]
  82. BrandM.D. GoncalvesR.L.S. OrrA.L. VargasL. GerencserA.A. JensenM.B. WangY.T. MelovS. TurkC.N. MatzenJ.T. DardovV.J. PetrassiH.M. MeeusenS.L. PerevoshchikovaI.V. JasperH. BrookesP.S. AinscowE.K. Suppressors of superoxide-H2O2 production at site IQ of mitochondrial complex I protect against stem cell hyperplasia and ischemia-reperfusion injury.Cell Metab.201624458259210.1016/j.cmet.2016.08.01227667666
     [Google Scholar]
  83. MontezanoA.C. TouyzR.M. Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies.Ann. Med.201244Suppl. 1S2S1610.3109/07853890.2011.65339322713144
     [Google Scholar]
  84. RodrigoR. RiveraG. Renal damage mediated by oxidative stress: A hypothesis of protective effects of red wine.Free Radic. Biol. Med.200233340942210.1016/S0891‑5849(02)00908‑512126763
     [Google Scholar]
  85. PiccoliC. QuaratoG. D’AprileA. MontemurnoE. ScrimaR. RipoliM. GomaraschiM. CirilloP. BoffoliD. CalabresiL. GesualdoL. CapitanioN. Native LDL-induced oxidative stress in human proximal tubular cells: Multiple players involved.J. Cell. Mol. Med.201115237539510.1111/j.1582‑4934.2009.00946.x19863698
     [Google Scholar]
  86. EvelsonP. TravacioM. RepettoM. EscobarJ. LlesuyS. LissiE.A. Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols.Arch. Biochem. Biophys.2001388226126610.1006/abbi.2001.229211368163
     [Google Scholar]
  87. GhiadoniL. MagagnaA. VersariD. KardaszI. HuangY. TaddeiS. SalvettiA. Different effect of antihypertensive drugs on conduit artery endothelial function.Hypertension20034161281128610.1161/01.HYP.0000070956.57418.2212719441
     [Google Scholar]
  88. YoshidaJ. YamamotoK. ManoT. SakataY. NishikawaN. NishioM. OhtaniT. MiwaT. HoriM. MasuyamaT. AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure.Hypertension200443368669110.1161/01.HYP.0000118017.02160.fa14757777
     [Google Scholar]
  89. YueT.L. ChengH.Y. LyskoP.G. McKennaP.J. FeuersteinR. GuJ.L. LyskoK.A. DavisL.L. FeuersteinG. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger.J. Pharmacol. Exp. Ther.1992263192981357162
     [Google Scholar]
  90. SergM. KampusP. KalsJ. ZaguraM. ZilmerM. ZilmerK. KullisaarT. EhaJ. Nebivolol and metoprolol: Long-term effects on inflammation and oxidative stress in essential hypertension.Scand. J. Clin. Lab. Invest.201272542743210.3109/00365513.2012.69199122708640
     [Google Scholar]
  91. BekyarovaG.Y. IvanovaD.G. MadjovaV.H. Molecular mechanisms associating oxidative stress with endothelial dysfunction in the development of various vascular complications in diabetes mellitus.Folia Med. (Plovdiv)2007493-4131918504928
     [Google Scholar]
  92. ZhouM.S. SchulmanI.H. JaimesE.A. RaijL. Thiazide diuretics, endothelial function, and vascular oxidative stress.J. Hypertens.200826349450010.1097/HJH.0b013e3282f3e39d18300860
     [Google Scholar]
  93. Perez-ReyesE. Molecular physiology of low-voltage-activated t-type calcium channels.Physiol. Rev.200383111716110.1152/physrev.00018.200212506128
     [Google Scholar]
  94. TayeA. MorawietzH. Spironolactone inhibits NADPH oxidase-induced oxidative stress and enhances eNOS in human endothelial cells.Iran. J. Pharm. Res.201110232933724250362
     [Google Scholar]
  95. SorrientoD. De LucaN. TrimarcoB. IaccarinoG. The antioxidant therapy: New insights in the treatment of hypertension.Front. Physiol.2018925810.3389/fphys.2018.0025829618986
     [Google Scholar]
  96. FleschM. MaackC. CremersB. BäumerA.T. SüdkampM. BöhmM. Effect of beta-blockers on free radical-induced cardiac contractile dysfunction.Circulation1999100434635310.1161/01.CIR.100.4.34610421593
     [Google Scholar]
  97. KrzemińskaJ. WronkaM. MłynarskaE. FranczykB. RyszJ. Arterial hypertension-oxidative stress and inflammation.Antioxidants202211117210.3390/antiox1101017235052676
     [Google Scholar]
  98. WardN.C. HodgsonJ.M. CroftK.D. BurkeV. BeilinL.J. PuddeyI.B. The combination of vitamin C and grape-seed polyphenols increases blood pressure: A randomized, double-blind, placebo-controlled trial.J. Hypertens.200523242743410.1097/00004872‑200502000‑0002615662232
     [Google Scholar]
  99. BrionesA.M. TouyzR.M. Oxidative stress and hypertension: Current concepts.Curr. Hypertens. Rep.201012213514210.1007/s11906‑010‑0100‑z20424957
     [Google Scholar]
  100. RodrigoR. PratH. PassalacquaW. ArayaJ. BächlerJ.P. Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension.Clin. Sci. (Lond.)20081141062563410.1042/CS2007034317999638
     [Google Scholar]
  101. ArdalanM.R. Rafieian-KopaeiM. Antioxidant supplementation in hypertension.J. Renal Inj. Prev.201332394025340164
     [Google Scholar]
  102. SiasosG. TousoulisD. VlachopoulosC. AntoniadesC. StefanadiE. IoakeimidisN. AndreouI. ZisimosK. PapavassiliouA.G. StefanadisC. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals.Int. J. Cardiol.2008126339439910.1016/j.ijcard.2007.04.05717588688
     [Google Scholar]
  103. SiasosG. TousoulisD. VlachopoulosC. AntoniadesC. StefanadiE. IoakeimidisN. ZisimosK. SiasouZ. PapavassiliouA.G. StefanadisC. The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance.Am. J. Hypertens.200922658659210.1038/ajh.2009.5719300425
     [Google Scholar]
  104. TousoulisD. PlastirasA. SiasosG. OikonomouE. VerveniotisA. KokkouE. ManiatisK. GouliopoulosN. MiliouA. ParaskevopoulosT. StefanadisC. Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome.Atherosclerosis20142321101610.1016/j.atherosclerosis.2013.10.01424401211
     [Google Scholar]
  105. SiasosG. TousoulisD. OikonomouE. ZaromitidouM. VerveniotisA. PlastirasA. KioufisS. ManiatisK. MiliouA. SiasouZ. StefanadisC. PapavassiliouA.G. Effects of omega-3 fatty acids on endothelial function, arterial wall properties, inflammatory and fibrinolytic status in smokers: A cross over study.Int. J. Cardiol.2013166234034610.1016/j.ijcard.2011.10.08122100606
     [Google Scholar]
  106. SiasosG. TousoulisD. KokkouE. OikonomouE. KolliaM.E. VerveniotisA. GouliopoulosN. ZisimosK. PlastirasA. ManiatisK. StefanadisC. Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers.Am. J. Hypertens.2014271384510.1093/ajh/hpt17624061071
     [Google Scholar]
  107. PedreB. BarayeuU. EzeriņaD. DickT.P. The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species.Pharmacol. Ther.202122810791610.1016/j.pharmthera.2021.10791634171332
     [Google Scholar]
  108. TianN. RoseR.A. JordanS. DwyerT.M. HughsonM.D. ManningR.D.Jr. N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension.J. Hypertens.200624112263227010.1097/01.hjh.0000249705.42230.7317053549
     [Google Scholar]
  109. SongD. HutchingsS. PangC.C.Y. Chronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in rats.Eur. J. Pharmacol.20055081-320521010.1016/j.ejphar.2004.12.01815680273
     [Google Scholar]
  110. FanN.C. TsaiC.M. HsuC.N. HuangL.T. TainY.L. N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.BioMed Res. Int.201320131910.1155/2013/69631724455716
     [Google Scholar]
  111. FeigD.I. SoletskyB. JohnsonR.J. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: A randomized trial.JAMA2008300892493210.1001/jama.300.8.92418728266
     [Google Scholar]
  112. GeorgeJ. StruthersA. The role of urate and xanthine oxidase in vascular oxidative stress: Future directions.Ther. Clin. Risk Manag.2009579980310.2147/TCRM.S570119851527
     [Google Scholar]
  113. SandersonK. van RijA.M. WadeC.R. SutherlandW.H. Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.Atherosclerosis19951181455110.1016/0021‑9150(95)05591‑J8579630
     [Google Scholar]
  114. NacítarhanS. ÖzbenT. TuncerN. Serum and urine malondialdehyde levels in NIDDM patients with and without hyperlipidemia.Free Radic. Biol. Med.199519689389610.1016/0891‑5849(95)00096‑G8582665
     [Google Scholar]
  115. SchwedhelmE. BartlingA. LenzenH. TsikasD. MaasR. BrümmerJ. GutzkiF.M. BergerJ. FrölichJ.C. BögerR.H. Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: A matched case-control study.Circulation2004109784384810.1161/01.CIR.0000116761.93647.3014757688
     [Google Scholar]
  116. YamaguchiY. KunitomoM. HaginakaJ. Assay methods of modified lipoproteins in plasma.J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.20027811-231333010.1016/S1570‑0232(02)00433‑612450666
     [Google Scholar]
  117. GutteridgeJ.M.C. Aspects to consider when detecting and measuring lipid peroxidation.Free Radic. Res. Commun.19861317318410.3109/107157686090831492577734
     [Google Scholar]
  118. BevanR.J. DurandM.F. HickenbothamP.T. KitasG.D. PatelP.R. PodmoreI.D. GriffithsH.R. WallerH.L. LunecJ. Validation of a novel ELISA for measurement of MDA-LDL in human plasma.Free Radic. Biol. Med.200335551752710.1016/S0891‑5849(03)00359‑912927601
     [Google Scholar]
  119. Vazquez-AgraN. Marques-AfonsoA.T. Cruces-SandeA. Mendez-AlvarezE. Soto-OteroR. Lopez-PazJ.E. Pose-ReinoA. Hermida-AmeijeirasA. Assessment of oxidative stress markers in hypertensive patients under the use of renin-angiotensin-aldosterone blockers.Antioxidants202312480210.3390/antiox1204080237107177
     [Google Scholar]
  120. DaviG. AlessandriniP. MezzettiA. MinottiG. BucciarelliT. CostantiniF. CipolloneF. BonG.B. CiabattoniG. PatronoC. In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia.Arterioscler. Thromb. Vasc. Biol.199717113230323510.1161/01.ATV.17.11.32309409316
     [Google Scholar]
  121. AwadJ.A. MorrowJ.D. TakahashiK. RobertsL.J.II Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.J. Biol. Chem.199326864161416910.1016/S0021‑9258(18)53593‑68440704
     [Google Scholar]
  122. LawsonJ.A. FitzGeraldG.A. RokachJ. Isoprostanes: Formation, analysis and use as indices of lipid peroxidation in vivo.J. Biol. Chem.199927435244412444410.1074/jbc.274.35.2444110455102
     [Google Scholar]
  123. MorrowJ.D. FreiB. LongmireA.W. GazianoJ.M. LynchS.M. ShyrY. StraussW.E. OatesJ.A. RobertsL.J.II Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage.N. Engl. J. Med.1995332181198120310.1056/NEJM1995050433218047700313
     [Google Scholar]
  124. MilneG.L. MusiekE.S. MorrowJ.D. F2-isoprostanes as markers of oxidative stress in vivo : An overview.Biomarkers200510Suppl. 1102310.1080/1354750050021654616298907
     [Google Scholar]
  125. van ’t ErveT.J. KadiiskaM.B. LondonS.J. MasonR.P. Classifying oxidative stress by F2-isoprostane levels across human diseases: A meta-analysis.Redox Biol.20171258259910.1016/j.redox.2017.03.02428391180
     [Google Scholar]
  126. YıldırımE. İpekE. BavunoğluI. YıldırımN. CengizM. YavuzerS. YavuzerH. ErmanH. UzunH. The impact of protein oxidation on sustained and white coat hypertension.Anatol. J. Cardiol.201717321021627684518
     [Google Scholar]
  127. XuH. Cabezas-RodriguezI. QureshiA.R. HeimburgerO. BaranyP. SnaedalS. AnderstamB. HelinA.C.B. CarreroJ.J. StenvinkelP. LindholmB. Increased levels of modified advanced oxidation protein products are associated with central and peripheral blood pressure in peritoneal dialysis patients.Perit. Dial. Int.201535446047010.3747/pdi.2013.0006424584606
     [Google Scholar]
  128. ContiG. CaccamoD. SiligatoR. GembilloG. SattaE. PazzanoD. CarucciN. CarellaA. Del CampoG. SalvoA. SantoroD. Association of higher advanced oxidation protein products (AOPPs) levels in patients with diabetic and hypertensive nephropathy.Medicina (Kaunas)2019551067510.3390/medicina5510067531591338
     [Google Scholar]
  129. GreenL.C. WagnerD.A. GlogowskiJ. SkipperP.L. WishnokJ.S. TannenbaumS.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.Anal. Biochem.1982126113113810.1016/0003‑2697(82)90118‑X7181105
     [Google Scholar]
  130. TsikasD. Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: Appraisal of the Griess reaction in the l-arginine/nitric oxide area of research.J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.20078511-2517010.1016/j.jchromb.2006.07.05416950667
     [Google Scholar]
  131. KalinovicS. StammP. OelzeM. DaubS. Kröller-SchönS. KvandovaM. StevenS. MünzelT. DaiberA. Comparison of three methods for in vivo quantification of glutathione in tissues of hypertensive rats.Free Radic. Res.20215511-121048106110.1080/10715762.2021.201673534918601
     [Google Scholar]
  132. RybkaJ. KupczykD. Kędziora-KornatowskaK. MotylJ. CzuczejkoJ. Szewczyk-GolecK. KozakiewiczM. PawlukH. CarvalhoL.A. KędzioraJ. Glutathione-related antioxidant defense system in elderly patients treated for hypertension.Cardiovasc. Toxicol.20111111910.1007/s12012‑010‑9096‑521140238
     [Google Scholar]
  133. YoungI.S. Measurement of total antioxidant capacity.J. Clin. Pathol.200154533910.1136/jcp.54.5.33911328830
     [Google Scholar]
  134. DuffyS.J. KeaneyJ.F.Jr. HolbrookM. GokceN. SwerdloffP.L. FreiB. VitaJ.A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease.Circulation2001104215115610.1161/01.CIR.104.2.15111447078
     [Google Scholar]
/content/journals/cmc/10.2174/0109298673325682241114162014
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Oxidative Stress Biomarkers in Hypertension
Bentham Science Publishers ; https://doi.org/10.2174/0109298673325682241114162014
/content/journals/cmc/10.2174/0109298673325682241114162014
/content/journals/cmc/10.2174/0109298673325682241114162014
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  • Article Type:     Review Article
Keywords: ACE inhibitors ; reactive oxygen species ; cardiovascular system ; oxidative stress ; endothelium ; Arterial hypertension

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