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Current Medicinal Chemistry - Online First
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Mechanisms and Characteristics of Chronic Pain in Alzheimer’s Disease: A Narrative Review
Authors: Roman Konovalov, Mina Aubakirova and Dmitriy VidermanAvailable online: 15 April 2025More LessAlzheimer’s disease is a neurodegenerative illness that significantly diminishes patients’ quality of life. Chronic pain remains a major contributor to exacerbating patients’ well-being. This comprehensive review aims to explore the mechanisms underlying pain perception in AD as well as identify potential targets and future considerations for pain relief. AD causes structural and functional alterations in the affected brain, including Read More
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COL4A1 Promotes Gastric Cancer Progression by Regulating Tumor Invasion, Tumor Microenvironment and Drug Sensitivity
Authors: Xiaojun Qian, Wei Jia, Yuntian Li, Jian Chen, Jinguo Zhang and Yubei SunAvailable online: 07 April 2025More LessBackground Collagen type IV alpha 1 chain (COL4A1), which has been proven to be a potential biomarker in Gastric Cancer (GC), but its role in tumors and the tumor microenvironment (TME) needs further explanation. Methods We analysed the relationship between COL4A1 and clinical characteristics based on The Cancer Genome Atlas (TCGA) database and verified by tissue microarrays as well as GC cell lines using im Read More
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Immunogenic Cell Death-relevant Molecular Patterns, Prognostic Genes, and Implications for Immunotherapy in Ovarian Cancer
Authors: Pijun Gong, Jia Li, Yinbin Zhang and Shuqun ZhangAvailable online: 03 April 2025More LessBackground Ovarian cancer (OV) is one of the deadliest gynecologic cancers, and approximately 75% of serous ovarian cancer (SOC) patients are diagnosed at advanced stages due to the lack of effective biomarkers. Objective Immunogenic cell death (ICD) has been investigated in many comprehensive studies, and the role of ICD in ovarian cancer and its impact on immunotherapy is not yet known. Methods The NMF clus Read More
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Machine Learning-based Gene Biomarker Identification for Improving Prognosis and Therapy in Hepatocellular Carcinoma
Authors: Lingyan Deng, Lei Dou, Xinyu Huang, Peng Wang and Na ShenAvailable online: 03 April 2025More LessIntroduction Traditional clinical evaluations based on pathological classification have shown limited effectiveness in predicting prognosis and guiding treatment for patients with hepatocellular carcinoma (HCC). This study aims to identify a robust molecular biomarker for improving prognosis and therapy in HCC. Methods The International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), and The Cancer Geno Read More
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Prognostic Role of Global DNA Methylation in Renal Cancer Reveals Decitabine Treatment Benefit
Authors: Wei Wu, Bin Huang, Peng Xia, Quanzhong Liu, Jin Yi, Ruohan Zhang and Qianghu WangAvailable online: 12 March 2025More LessBackground Renal cancer presents a significant global health challenge due to its rising incidence and mortality rates. Often undetected in early stages, it complicates diagnosis and treatment. Current therapies face resistance and limited effectiveness, especially in advanced stages. The diverse subtypes of renal cancer highlight the need for new biomarkers and risk assessment tools for targeted treatments. Objective Thi Read More
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Near-infrared (NIR) Fluorophores in Cancer Bioimaging and Therapy
Authors: Libo Yan, Weiming Zhang, Daogang Wang, Min Zhang, Ning Xu, Mengzhe Yang and Tao RenAvailable online: 12 March 2025More LessThe development of multiple fluorescent agents has contributed to cancer diagnosis and therapy. Near-infrared (NIR) dyes have already been well studied and displayed significant potential in cancer bioimaging and therapy due to their unique characteristics. In the present literature, we illustrated the updated NIR classification and characteristics as well as their applications in (pre-) clinical cancer imaging and treatment. Read More
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Six Decades of Scientific Output: A Bibliometric Analysis of Research Contributions from the National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”
Authors: Carmen Rubio, Rudy Luna, David Vazquez, Veronica Perez de la Cruz, Benjamin Pineda and Antonio ArauzAvailable online: 10 March 2025More LessIntroduction The Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), established nearly six decades ago, was initially designed as a specialized hospital for neurological care. However, over time, it has evolved into a multifaceted health institute, encompassing three fundamental pillars: clinical care, scientific research, and academic education in neurology. Aims and Objectives Th Read More
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Development of an Inflammation-related Gene-based Diagnostic Risk Model and Immune Infiltration Analysis in Bipolar Disorder
Available online: 05 March 2025More LessObjective This study aimed to construct a diagnostic risk model for Bipolar Disorder (BD) using inflammation-related genes (IRGs) and to explore the role of immune cell infiltration in BD pathogenesis. Methods BD datasets (GSE23848, GSE124326, GSE39653, and GSE46449) were retrieved from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the edgeR package. Th Read More
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Decoding Colorectal Cancer: Key Genes and Pathways in the Chinese Population Revealed
Authors: Dongbing Li and Guizhen LyuAvailable online: 03 March 2025More LessBackground As the leading cause of cancer-related deaths globally, colorectal cancer (CRC) ranks third in prevalence. Gene Expression Omnibus (GEO) offers clinicians and bioinformaticians an accessible platform for genomic research across various cancer types, with a particular emphasis on CRC. Objective We aim to uncover key genes and pathways in the Chinese CRC population. Methods We identified differentially expres Read More
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NADPH Oxidase: A Potential Therapeutic Target to Reduce Primary Sclerosis Cholangitis Following Liver Transplantation
Available online: 26 February 2025More LessThe molecular mechanisms and causes of primary sclerosis cholangitis (PSC) post-liver transplantation are still unclear. PSC is a progressive cholestatic hepatobiliary disease that happens in about 25% of patients post-liver transplantation and requires re-transplantation. Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase or Nox) is a family of transmembrane proteins whose main function is produci Read More
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Molecular and Biochemical Evidence of Edaravone's Impact on Dasatinib-induced AGS Cell Senescence: A Promising Strategy for Gastric Cancer Therapy
Available online: 24 February 2025More LessIntroduction Internal or external stress can induce cellular senescence, which reduces cell division. These metabolically active cells contribute to medication resistance. We examined the potential for edaravone (Eda) to cause apoptosis in dasatinib (Das)-induced senescent gastric adenocarcinoma cells (AGS). Our goal was to develop a new stomach cancer treatment. Methods All Eda doses evaluated were nontoxic Read More
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HER3-targeting Antibody-drug Conjugates Therapy for Solid Tumors: Recent Advances and Future Potentials
Authors: Xuerui Wang, Linlin Zhao, Fangfang Gao, Yuan Meng, Jie Yang, Meiying Zhu, Dongying Liao, Yingjie Jia and Fanming KongAvailable online: 24 February 2025More LessIn most advanced cancers, standard medical treatments are generally employed. With the emergence of Antibody-Drug Conjugates (ADCs), more optimal therapeutic methods have become available for treating tumors. ADC is composed of a monoclonal antibody that targets a specific antigen and a cytotoxic payload, which conjugates via the synthetic linkers. Therefore, ADC combines the accurate targeting of monoclonal anti Read More
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Osteoporosis: Relevance of Biomolecules for Diagnosis and Treatment
Available online: 24 February 2025More LessOsteoporosis, a metabolic disorder distinguished by decreased bone density and degradation of bone tissue microarchitecture, is a silent disease that evolves without any clinical symptoms or signs. An individual may not be aware of osteoporosis until a fracture occurs. The lifetime risk of osteoporosis is estimated to be between 10 and 20%. The disease can have intrinsic causes, like genetic predisposition, aging, and lack Read More
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Dermal Melanocytes Detectability for Distinguishing In Situ and Early Invasive Melanoma: A Narrative Review
Available online: 18 February 2025More LessThe melanoma incidence has been increasing over the past three decades, with a disproportionately high fraction of in situ tumors. The diagnosis of melanoma at its earliest stages can be challenging. The detectability of tumor melanocytes in the dermis is of key importance for distinguishing in situ from invasive melanomas. In this review, a total of 475 melanomas diagnosed as in situ tumors by hematoxylin and eosin staining Read More
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Exploring the Diet-diverticular Disease Link: Insights from a Comprehensive Mendelian Randomization Study
Authors: Jie Zhou, Yixin Xu, Haitao Wang, Kun Wang and Chao ChenAvailable online: 18 February 2025More LessBackground The interplay between dietary habits and the development of Diverticular Disease (DD) has long been a subject of vibrant debate. Objective Utilizing Mendelian Randomization (MR), this study aims to meticulously examine the causal dynamics at play. Methods The foundation for the Genome-Wide Association Studies (GWAS) on DD was established using a dataset from the FinnGen consortium, encompassing 33,61 Read More
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Evaluation of Antiseptic Drug Candidate Pyridosept in Preclinical in Vitro Studies
Authors: Renata Kazakova, Alfiya Iksanova, Mariya Agafonova, Anna Lubina, Elena Bulatova, Elena Nikitina, Svetlana Lisovskaya, Airat Kayumov, Oxana Bondar, Albina Malanyeva, Olga Vasileva, Marina Zeldi, Alina Gatina, Sergei Koshkin, Natalia Komcharova, Yulia Konyakhina, Kseniia Titova, Aleksandr Sergeev, Sergey Sapozhnikov, Nikita Shtyrlin and Yurii ShtyrlinAvailable online: 18 February 2025More LessIntroduction This work provides preclinical in vitro studies of an innovative antimicrobial agent named pyridosept, belonging to the quaternary bis-ammonium salts and synthesized on the base of pyridoxine. Since the wide spread of pathogens with tolerance to both antibiotics and antiseptics challenges the development of new antimicrobials providing high efficiency against fungi and microorganisms with multiple resistance. Read More
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DDX59-AS1: A Novel Prognostic Biomarker and Immunotherapy Predictor in Lung Adenocarcinoma
Authors: Yanli Wang, Wei Li, Su Wei, Lixi Zhang, Dongbing Li and Xu QiAvailable online: 18 February 2025More LessBackground The precise function of DDX59 Antisense RNA 1 (DDX59-AS1) in lung adenocarcinoma (LUAD) has yet to be fully elucidated. Objective This study uses bioinformatics analysis and experimental validation to investigate the association between DDX59-AS1 and LUAD. Methods This study uses statistical analysis and database interrogation to investigate the potential association between DDX59-AS1 expression and va Read More
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Bibliometric Analysis of Research on Traditional Chinese Medicine Treatment of Myocardial Infarction from 2007 to 2024 Based on the Web of Science Database
Authors: Qi Lan, Hao Wu, Ming-Tai Chen, Jin-Yi Xue, Maryam Mazhar, Zi-Wen Deng, Yuan Zou, Ping Liu, Gang Luo, Li Dong and Meng-Nan LiuAvailable online: 18 February 2025More LessBackground Myocardial infarction (MI) is a common critical syndrome in the late development of cardiovascular diseases (CVDs), and traditional Chinese Medicine (TCM) treatment has become an essential branch in this field. Objective This study aimed to use bibliometric methods to examine the research trajectory of TCM treatment of MI from 2007 to 2024 from a multidimensional perspective and analyse its characteristics, Read More
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Protective Effect of Curcumin on Metabolic Syndrome Components through the Microbiota
Available online: 18 February 2025More LessCurcumin, a natural polyphenolic compound found in turmeric, has garnered increasing research interest due to its potential health benefits, particularly in the context of the rising global prevalence of metabolic syndrome (MetS). With MetS affecting a significant portion of the global population and serving as a precursor to chronic diseases, such as type 2 diabetes and cardiovascular diseases, identifying effective, ac Read More
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Identification of Ferroptosis-Related Prognostic Models and FDFT1 as a Potential Ferroptosis Driver in Colorectal Cancer
Authors: Lili Duan, Lu Cao, Jinqiang Liu, Zixiang Wang, Jie Liang, Fan Feng, Jian Zhang, Liu Hong and Jianyong ZhengAvailable online: 13 February 2025More LessAims We aimed to develop Ferroptosis-Related Gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with colorectal cancer (CRC). Background Prediction of CRC prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains unexplored. Objective This research endeavored to establish a prognostic risk sig Read More
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