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image of LNX1-AS2 as a Key Prognostic and Immunotherapy Response Biomarker for Lung Adenocarcinoma

Abstract

Background

The role of LNX1 antisense RNA 2 (LNX1-AS2) in lung adenocarcinoma (LUAD) remains unclear.

Objective

This study aimed to investigate the association between LNX1-AS2 and LUAD by employing bioinformatics analysis and experimental validation.

Methods

Statistical analysis and database interrogation were utilized to assess correlations among LNX1-AS2 expression, clinical characteristics of LUAD patients, prognostic factors, regulatory networks, and immune infiltration. LNX1-AS2 expression in LUAD cell lines was quantified using quantitative real-time polymerase chain reaction (qRT-PCR).

Results

The study found significantly elevated levels of LNX1-AS2 expression in patients with LUAD. Furthermore, elevated LNX1-AS2 expression in LUAD patients did not significantly correlate with gender ( = 0.041) or race ( = 0.049). Importantly, high LNX1-AS2 expression levels were associated with poorer overall survival (OS, = 0.042) and disease-specific survival (DSS, = 0.040) in LUAD patients. Additionally, high LNX1-AS2 expression ( = 0.015) was independently correlated with OS in LUAD patients. The phenotype characterized by high LNX1-AS2 expression was also found to be enriched for asthma, allograft rejection, drug metabolism cytochrome P450, metabolism of xenobiotics by cytochrome P450, olfactory transduction, renin-angiotensin system, retinol metabolism, pentose and glucuronate interconversions, and porphyrin and chlorophyll metabolism. A significant correlation was identified between the expression levels of LNX1-AS2 and immune infiltration in the context of LUAD. Elevated expression of LNX1-AS2 was notably detected in LUAD cell lines as opposed to Beas-2B.

Conclusion

A noteworthy relationship was established among increased LNX1-AS2 expression in LUAD patients, unfavorable prognosis, and heightened immune infiltration. These findings suggest that the LNX1-AS2 gene could serve as a valuable prognostic indicator for LUAD and a potential predictor of response to immunotherapy.

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2024-10-31
2024-11-26

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/content/journals/cmc/10.2174/0109298673321029241015153958
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LNX1-AS2 as a Key Prognostic and Immunotherapy Response Biomarker for Lung Adenocarcinoma
Bentham Science Publishers ; https://doi.org/10.2174/0109298673321029241015153958
/content/journals/cmc/10.2174/0109298673321029241015153958
/content/journals/cmc/10.2174/0109298673321029241015153958
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  • Article Type:     Research Article
Keywords: prognosis ; Lung adenocarcinoma ; LNX1-AS2 ; expression ; immune infiltration ; biomarker

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