Natural Products Journal, The - Online First

Background Peperomia pellucida is a medicinal and vegetable plant used worldwide, representing a multi-purpose vegetable with applications in the pharmaceutical, food and cosmetic industries. Objective This study evaluated the antioxidant, antibacterial, antifungal, anti-inflammatory, and antidiabetic potential of fractional extracts from P. pellucida plant derived from Can Tho City, Vietnam. Methods Four fractional extracts Read More

The complex etiology of Gouty Arthritis (GA) makes it a multidimensional illness for which there are now no effective therapeutic therapies that can stop its development entirely. This review examines how effectively different plants and their constituents reduce blood uric acid levels and lessen the predisposition to gout. Research has looked at the possible roles of oxidative stress markers, inflammatory pathways, important tran Read More

Breast cancer, a pervasive global malignancy, is anticipated to undergo a significant increase by 2040. Despite the conventional armamentarium of treatments including chemotherapy, radiation therapy, and surgery, the intricate landscape of breast cancer, characterized by its multifaceted surface receptors and signalling pathways, presents formidable challenges to treatment efficacy. Epigallocatechin-3-gallate (EGCG), extr Read More

In this study, we utilized high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (HPLC-Q-TOF/MS/MS), combined with electrospray ionization in the positive mode (ESI+), to establish a comprehensive framework for chromatographic separation and mass spectrometric detection. The primary focus was on performing collision-induced dissociation (CID) experiments on levantilide D, a Read More

The lack of melanin-producing cells in the epidermis causes white patches to develop in vitiligo, a chronic skin disorder. Although vitiligo seldom causes physical injury, it can have serious psychological and social consequences, such as diminished self-confidence and feelings of inadequacy. While there is no known cure for vitiligo, there are several treatments that can help control the illness and lessen its impact on people's l Read More

Background Stemona tuberosa Lour. is a plant belonging to the genus Stemona (Stemonaceae) that has been utilized in traditional Chinese medicine (TCM) for its antitussive and antiparasitic properties. Endophytic fungi have been shown to play an important role in the growth and metabolism of plants. Fermentation involving endophytic fungi tends to result in the production of new or more potent pharmacological Read More

The investigation of computational techniques to forecast the bioactivity of natural substances has been spurred by the growing interest in utilizing their medicinal potential. A branch of artificial intelligence called deep learning has been particularly useful for predicting outcomes in a variety of fields, such as bioactivity prediction and drug discovery, by evaluating large amounts of complex data. An overview of current developm Read More

The present review comprehensively explores an overview of a versatile essential oil from genus Lavandula. Oil finds wide application in the aromatherapy and cosmetic industry. This paper emphasizes the chemical constituents of the oil that are responsible for the diverse therapeutic applications. Various extraction techniques, such as steam distillation, hydro distillation, supercritical liquid extraction and ultrasound ass Read More

Of the several forms of breast cancer, triple-negative breast cancer (TNBC) is the most aggressive, is not responsive to traditional human/hormonal epithelial growth factor receptor 2 (HER2)-targeted therapies because the corresponding receptor targets are absent, TNBC tends to be more invasive in form, metastasis, have an early recurrence rate and develop medication resistance. For TNBC, some of the most popular typ Read More

Natural substances are gaining interest as anticancer agents nowadays due to the adverse effects of synthetic drugs. Among various natural substances, lycopene has emerged as a strong antioxidant agent and has been found to be effective against prostate, breast, colon, ovarian, liver, endometrial cancers, etc. This article reviews the therapeutic potential and proposed mechanism of action of lycopene against breast a Read More

In this review, recent advances in the microbial oxidation and ring rearrangement of various terpenoidal compounds by Aspergillus niger are reviewed. Studies on hydroxylation, acid and keto formations, Baeyer-Villiger oxidation, and ring rearrangements are also explored. Moreover, various terpenoidal compound substrates and their metabolites used for fungal biotransformations are compiled. This review attempts t Read More

Quzhiqiao is a Chinese herbal medicine widely used in Zhejiang Province of China, which originates from the cultivar Citrus aurantiun ‘Changshanhuyou’, named Changshanhuyou in Chinese. Citrus aurantiun ‘Changshanhuyou’ is a botanical variety of C. aurantium L., which is obtained after long-term domestication. It belongs to the Rutaceae family and mainly grows in Changshan County, Zhejiang Province, C Read More

Background and Aim Diabetic foot ulcers (DFUs) constitute one of the most debilitating complications of diabetes mellitus (DM). The use of topical herbal products as adjuvant agents in wound dressing is one of the most widely used practices worldwide. The present review aimed to provide a detailed and comprehensive systematic review focusing on randomized clinical studies and critically analyze not only the clinical outcom Read More

Tea is a popular beverage that comprises various antioxidants. Tea is the second most consumed beverage in the world after water. The three ideal types of tea include black, white, and green teas. Catechin, Epicatechin gallate, and Epicatechin are the striped flavonoids coeval in the tea. These flavonoids are freed as a rich source for blood circulation in the heart. Tea possesses anti-inflammatory, anti-neoplastic, anti-arthritic, an Read More

Non-Small Cell Lung Cancer (NSCLC) holds a significant position globally among cancer types. Alkaloids, which are natural compounds containing nitrogen atoms, are found in various plant sources and play a crucial role in anti-cancer activity, offering potential therapeutic applications. They are classified by their chemical structure into categories such as indole alkaloids, isoquinoline alkaloids, pyrrole and pyrrolizidine alkaloid Read More

Introduction The Chinese medicine, Kanglao concoction has been used clinically to treat tuberculosis. However, its constituents and anti-inflammatory activity have not been fully understood. Method In this study, HPLC-MS2 has been employed to determine the main constituents in the concoction. The anti-inflammatory activity has been investigated by ELISA and Western Blot techniques. The MS analysis revealed th Read More

Aim To evaluate the anti-oxidative and radioprotective role of Pontibacter indicus SCG24 pigment during radiation exposure Background Radiation-induced cytotoxicity is quite common during cancer therapy. There is a need for naturally derived therapeutic molecules that can scavenge free radicals. They may act as substitutes for synthetic molecules. Hence, there is a need for urgent evaluation of these potent compounds b Read More

Introduction One new levantilide D (2) with a 20-membered macrolide, along with one known levantilide C (1), was isolated from a rare marine actinomycetes Micromonospora sp. (FIMYZ52). Method The structural elucidation of the compounds was based on integrated analyses involving 1D and 2D NMR spectroscopy and HR-ESI-MS. Result The relative and absolute configurations of compounds 1 and 2 were ascertained by in Read More

Cynometra cauliflora Linn. (C. cauliflora), a member of the Fabaceae family within the Cynometra genus, is an underrated medicinal plant in Malaysia. It features frog-like fruits and is known locally as Namnam. The plant grows in tropical regions and is used in the traditional treatment of various medical conditions. Previous studies have revealed a broad range of its pharmacological benefits, including antioxidant, anti-infl Read More