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Volume 15, Issue 2
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

Roxb., a new species of the Zingiberaceae family, is found profoundly in the Northeastern region of India. It is a rhizomatous geophyte and grows primarily in the seasonally dry tropical biome native to Indo-China regimens.

Objective

The aim is to research the root part of this plant to discover active constituents and evaluate the molecular mechanism of antidiabetic activity.

Methods

The hydroalcoholic root extract of this plant (HAZR) was evaluated for antioxidant assays α-amylase and α-glucosidase inhibition assay. Further, the antidiabetic activity assay was evaluated, exploring the molecular mechanism for modulating oxidative stress in tissue biochemical parameters and HbA1c. To explore the molecular mechanism, we also investigated the inhibition assay of protein kinase C (PKC) phosphorylation in mouse peritoneal macrophages.

Results

The experiments' results helped to conclude that HAZR has potent antioxidant and antidiabetic activity and could have been embedded with potent active molecules. They also revealed the mechanism of action as inhibition of PKC phosphorylation, meriting further studies.

Conclusion

The present study revealed that HAZR demonstrated its antidiabetic activity against diabetic animal models through oxidative stress-mediated PKC and TGF-β regulation in diabetic individuals.

© 2025 Bentham Science Publishers
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2025-02-01
2024-11-22

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Exploration of the Molecular Mechanism Underlying the Antidiabetic Activity of a Northeast Indian Plant Zingiber rubens Roxb. through Modulation of PKC Phosphorylation
Natural Products Journal, The 15, E150424228899 (2025); https://doi.org/10.2174/0122103155292112240407113802
/content/journals/npj/10.2174/0122103155292112240407113802
/content/journals/npj/10.2174/0122103155292112240407113802
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  • Article Type:     Research Article
Keyword(s): antidiabetic activity; HbA1c; inhibition of protein kinase C; modulation of oxidative stress; PKC; Zingiber rubens roxb.

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