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image of Antimicrobial Macrolide Levantilide D from Rare Marine Micromonospora sp.

Abstract

Introduction

One new levantilide D () with a 20-membered macrolide, along with one known levantilide C (), was isolated from a rare marine actinomycetes sp. (FIMYZ52).

Method

The structural elucidation of the compounds was based on integrated analyses involving 1D and 2D NMR spectroscopy and HR-ESI-MS.

Result

The relative and absolute configurations of compounds and were ascertained integrating multispectral ROESY and NOESY information from analogs in conjunction with theoretical TDDFT-ECD calculations. Levantilide D (2) exhibited antibacterial activity against Staphylococcus aureus.

Conclusion

A plausible biosynthetic pathway of the macrolide compounds (-) was proposed.

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2024-10-10
2025-02-17
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