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2000
Volume 16, Issue 3
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Quzhiqiao is a Chinese herbal medicine widely used in Zhejiang Province of China, which originates from the cultivar ‘Changshanhuyou’, named Changshanhuyou in Chinese. ‘Changshanhuyou’ is a botanical variety of L., which is obtained after long-term domestication. It belongs to the Rutaceae family and mainly grows in Changshan County, Zhejiang Province, China. Quzhiqiao is an authentic Chinese medicinal material in the Zhejiang area with various pharmacological and curative effects. A comprehensive review and in-depth analysis of scientific literature on Quzhiqiao was conducted, utilizing diverse electronic databases and additional sources. This review provides a comprehensive overview of its chemical components, standardized quality control, pharmacological activity, and mechanism of action, which also outlines future perspectives, highlighting the necessity for further research for harnessing the potential of the therapeutic use of Quzhiqiao.

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2026-02-19

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References

  1. YangB. WangL. WangM. General situation of Changshanhuyou Quzhiqiao industry development.Zhejiang Ganju20193679
     [Google Scholar]
  2. JiangB. DingH. WangY. WuY. QianK. Pharmacological Research Progress of Fructus Aurantii.Yunnan J Tradit Chin Med Mater. Med.2022437075
     [Google Scholar]
  3. Zhejiang Province traditional Chinese medicine processing standards.BeijingChina Medical Science Press2016
     [Google Scholar]
  4. GuoZ. ZhaoW. QiY. LiW. Description of monograph changes in Zhejiang province of processing chinese crud drugs 2015 edition.Chin. J. Mod. Appl. Pharm.201633790792
     [Google Scholar]
  5. ZhangQ. SongW. TaoG. LiQ. WangL. HuangW. GaoL. YinL. YeY. Comparison of chemical compositions and antioxidant activities for the immature fruits of Citrus changshan-huyou Y.B. Chang and Citrus aurantium L.Molecules20232813505710.3390/molecules28135057 37446717
     [Google Scholar]
  6. WeiX. JingJ. HuangR. ZhouT. WuL. OuG. WuY. HuJ. ZhuW. WuY. LiY. ZhangS. YouZ. QFAE-nB alleviates pulmonary fibrosis by inhibiting the STING pathway in mice.J. Ethnopharmacol.2024319Pt 211729510.1016/j.jep.2023.117295 37806536
     [Google Scholar]
  7. YingY. WanH. ZhaoX. YuL. HeY. JinW. Pharmacokinetic-pharmacodynamic modeling of the antioxidant activity of quzhou fructus aurantii decoction in a rat model of hyperlipidemia.Biomed. Pharmacother.202013111064610.1016/j.biopha.2020.110646 32942150
     [Google Scholar]
  8. GaoL. ZhangY.L. WuY. ShaoJ. ZhangH. ShaoY. XuY. JiangJ. Study on the mechanism of the flavonoids from the new “Zhe Eight Flavors” Quzhou Fructus Aurantii against hepatocellular carcinoma based on network pharmacology. Chin J Mod Appl.Pharm.202441166176
     [Google Scholar]
  9. ChenZ.Y. LiJ.S. JiangJ.P. YanM.X. HeB.H. Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1α pathway in mice with NASH.Zhongguo Zhongyao Zazhi2014391100105 24754177
     [Google Scholar]
  10. WangX. WangS. FangY. HuZ. ZhongS. LouL. Study on the hypoglycemic activity of different components of quzhiqiao in vitro and analysis of four flavonoids.Chin. J. Mod. Appl. Pharm.20173414181423
     [Google Scholar]
  11. YeA. JiangJ. LiR. JinL. WuX. WangJ. Study on hypolipidemic effect of pure total flavonoids from Qu Aurantii Fructus on golden hamsters of hyperlipidemia and its potential mechanism.Chin. J. Mod. Appl. Pharm.20203719381946
     [Google Scholar]
  12. XingN. ShuZ. XuB. JiaoW. WangQ. KuangH. Isolation, purification, and structural elucidation of polysaccharide CALB-1 from Aurantii Fructus and study on its immunoregulatory activity.Chin. Herb. Med.201546639644
     [Google Scholar]
  13. JiangL. TianX. YuanQ. LiuJ. CuiQ. Research progress on cultivation techniques of Citrus×aurantium ‘Changshanhuyou’ and chemical components and pharmacological action of Qu Aurantii Fructus.Zhejiang Linye Keji202242129136
     [Google Scholar]
  14. WuG. Characteristics and cultivation techniques of golden pomelo.South China Fruits1987011618
     [Google Scholar]
  15. XuC.J. BaoL. ZhangB. BeiZ.M. YeX.Y. ZhangS.L. ChenK.S. Parentage analysis of huyou (Citrus changshanensis) based on internal transcribed spacer sequences.Plant Breed.2006125551952210.1111/j.1439‑0523.2006.01263.x
     [Google Scholar]
  16. ZhaoW. HuangQ. ZhangW. YueC. SongJ. Research for the original plant of chinese medicinal materials Qu Aurantii Fructus.Chin. J. Mod. Appl. Pharm.20193616521655
     [Google Scholar]
  17. ZhangY. SongL. LiuS. RuanL. WangX. SongJ. WangL. XuQ. Genetic identification of ‘Changshanhuyou’(Citrus × aurantium L.) of different ages and propagation types.Zhiwu Kexue Xuebao202442191200
     [Google Scholar]
  18. YueC. The Survey of Chemical components and Pharmacological effects in Citrus changshan-huyou Y.B.Chang. and to compared with Fructus aurantia.Zhejiang Chinese Medical University2015
     [Google Scholar]
  19. ZhaoX. Studies on chemical components and pharmacological and biological activities in Huyou peels (Citrus Changshan-huyou Y. B. Chang).Zhejiang University2003
     [Google Scholar]
  20. JiangL. DongX. TianY. SongJ. ZhaoW. HuY. LiM. FengJ. Study on the material basis and mechanism of quzhiqiao’s hypoglycemic effect based on HPLC-Q-exactive orbitrap MS/MS integrated network pharmacology.Chin. J. Basic. Med. Tradit. Chin. Med.202430461467
     [Google Scholar]
  21. SunY. WangJ. GuS. LiuZ. ZhangY. ZhangX. Simultaneous determination of flavonoids in different parts of Citrus reticulata ‘Chachi’ fruit by high performance liquid chromatography-photodiode array detection.Molecules20101585378538810.3390/molecules15085378 20714303
     [Google Scholar]
  22. YanX. YanQ. LiuX. HuangH. ZhengZ. ShiT. Determination of neohesperidin and naringin in quzhiqiao by high performance liquid chromatography.Food Res Dev201839161166
     [Google Scholar]
  23. YueC. ZhangW. ZhengC. LiangJ. SongJ. ChenB. GuoZ. ZhaoW. Research on quality difference of Qu Aurantii Fructus and different Aurantii Fructus cultivars based on HPLC fingerprint.Chin. Herb. Med.20245527642770
     [Google Scholar]
  24. Pharmacopoeia of the People’s Republic of China 2020.BeijingChina Medical Science Press20201088
     [Google Scholar]
  25. ZhangH. WangL. WuY. BiX. WangG. ZhaoS. XuC. ChenK. Fruit quality analysis and comprehensive evaluation of 18 Huyou (Citrus changshanensis) accessions.Guoshu Xuebao20244110331043
     [Google Scholar]
  26. WangL. ZhengH. XuX. YangB. LiuC. HuangZ. LiH. XuL. Effects of drying process of young fruits of Changshan Huyou (Citrus aurantium L.) on quality of qu fructus aurantii products.South China Fruits2022513942
     [Google Scholar]
  27. LiuZ. YanZ. XuY. Study on extraction of flavonoids from huyou peel with ultrasonic assist of surfactant. Food.Res. Dev.202041125130
     [Google Scholar]
  28. SerafiniM. PelusoI. RaguzziniA. Flavonoids as anti-inflammatory agents.Proc. Nutr. Soc.201069327327810.1017/S002966511000162X 20569521
     [Google Scholar]
  29. TanR. MengJ. ChenD. JiaoQ. Plant composition analysis.Science Press2002
     [Google Scholar]
  30. YuD. WuJ. LiuY. WangL. YangX. YeX. ChenS. ChenJ. Analysis of main functional components in different parts of Citrus×aurantium L. Changshanhuyou fruits. J Zhejiang Univ Agric.Life Sci.202349802812
     [Google Scholar]
  31. HanG.Y. ShenQ.H. HanS.W. Flavonoid components and physiological biochemical activities of plant drugs.China Books Publishing House2010
     [Google Scholar]
  32. LiS. DaiY. ZhaoY. QinM. Research progress on distribution, biosynthesis and biological function of flavonoid C-glycosides.Res. Pract. Chin. Med.2023378894
     [Google Scholar]
  33. OhsugiT. NishidaR. FukamiH. Oviposition stimulant of Papilio xuthus, a Citrus-feeding swallowtail butterfly.Agric. Biol. Chem.19854961897190010.1271/bbb1961.49.1897
     [Google Scholar]
  34. SongY. WangY. ZhangC. YangH. Study quality markers for blood lipid-lowering effect of Moringa oleifera leaves based on specific chromatogram, network pharmacology and multi-index quantitative analysis.Chin. Herb. Med.20245516861698
     [Google Scholar]
  35. ZhangZ. ZhaoQ. LiuT. ZhaoH. WangR. LiH. ZhangY. ShanL. HeB. WangX. HuangL. HaoD. SunH. Effect of Vicenin-2 on ovariectomy-induced osteoporosis in rats.Biomed. Pharmacother.202012911047410.1016/j.biopha.2020.110474 32768959
     [Google Scholar]
  36. YanX. LiuX. YanQ. HuangH. ShiT. Study on neohesperidin and naringin of quzhiqiao in Changshan different regions.Food Eng.2019044043
     [Google Scholar]
  37. FangJ. WuX. JiangJ. MaoL. Related analysis between antioxidant activities and HPLC fingerprint of flavonoids in citrus changshan-huyou Y.B.Peels. Chin. J. Mod. Appl. Pharm.20183514891493
     [Google Scholar]
  38. ZhaoH. LiuM. LiuH. SuoR. LuC. Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway.Biosci. Rep.2020403BSR2019343110.1042/BSR20193431 32091090
     [Google Scholar]
  39. ZhangJ. HuiY. LiuF. YangQ. LuY. ChangY. LiuQ. DingY. Neohesperidin protects angiotensin II-induced hypertension and vascular remodeling.Front. Pharmacol.20221389020210.3389/fphar.2022.890202 35677431
     [Google Scholar]
  40. LiuY. NiuL. CuiL. HouX. LiJ. ZhangX. ZhangM. Hesperetin inhibits rat coronary constriction by inhibiting Ca2+ influx and enhancing voltage-gated K+ channel currents of the myocytes.Eur. J. Pharmacol.201473519320110.1016/j.ejphar.2014.03.057 24751712
     [Google Scholar]
  41. LiuS. GaoX. YinY. WangJ. DongK. ShiD. WuX. GuoC. Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.Food Chem. Toxicol.202317711384410.1016/j.fct.2023.113844 37244599
     [Google Scholar]
  42. VelusamyP. MohanT. RaviD.B. Kishore KumarS.N. SrinivasanA. ChakrapaniL.N. SinghA. VaradharajS. KalaiselviP. Targeting the Nrf2/ARE signalling pathway to mitigate isoproterenol-induced cardiac hypertrophy: Plausible role of hesperetin in redox homeostasis.Oxid. Med. Cell. Longev.2020202011310.1155/2020/9568278 32952852
     [Google Scholar]
  43. ZhangM. JingL. WuQ. ZhuK. KeF. XuJ. ZhaoS. WangG. ZhangC. Metabolite profile comparison of a graft chimera ‘Hongrou Huyou’ (Citrus changshan-huyou + Citrus unshiu) and its two donor plants.BMC Plant Biol.201919158210.1186/s12870‑019‑2173‑4 31878871
     [Google Scholar]
  44. LinZ.B. Contemporary Studies on Ganoderma lucidum.BeijingPeking Union Medical College and Beijing Medical University United Press2001219220
     [Google Scholar]
  45. LuoJ. LinZ.B. Advances of pharmacological effects of triterpenes from Ganoderma lucidum.Yao Xue Xue Bao2002377574578 12914332
     [Google Scholar]
  46. LuoJ. SunY. LiQ. KongL. Research progress of meliaceous limonoids from 2011 to 2021.Nat. Prod. Rep.20223961325136510.1039/D2NP00015F 35608367
     [Google Scholar]
  47. JinS. WangJ. ChenS. JiangA. JiangM. SuY. YanW. XuY. GongG. A novel limonin derivate modulates inflammatory response by suppressing the TLR4/NF-κB signalling pathway.Biomed. Pharmacother.201810050150810.1016/j.biopha.2018.02.046 29477914
     [Google Scholar]
  48. LiY. GengH. LiS. Analysis of the composition of essential oils from four citrus peels.Xiandai Shipin Keji201935264272
     [Google Scholar]
  49. HeD. ShanY. WuY. LiuG. ChenB. YaoS. Simultaneous determination of flavanones, hydroxycinnamic acids and alkaloids in citrus fruits by HPLC-DAD–ESI/MS.Food Chem.2011127288088510.1016/j.foodchem.2010.12.109 23140749
     [Google Scholar]
  50. LiuF. HuangY. YuanT. ZhangJ. RP-HPLC determining the quantity of sypephrine in Fructus Aurantii.Hunan Guid. J. Tradit. Chin. Med. Pharmacol.200210577578
     [Google Scholar]
  51. FengJ. SongJ. ZhaoS. XuL. ZhangW. LeiM. Study on spectrum-activity relationship of flavonoids in Qu Aurantii Fructus for regulation of gastrointestinal motility.Chin. J. Mod. Appl. Pharm.20223922412245
     [Google Scholar]
  52. LiG.J. WuH.J. WangY. HungW.L. RouseffR.L. Determination of citrus juice coumarins, furanocoumarins and methoxylated flavones using solid phase extraction and HPLC with photodiode array and fluorescence detection.Food Chem.2019271293810.1016/j.foodchem.2018.07.130 30236679
     [Google Scholar]
  53. LuuH. Isomeranzin against Herpes simplex virus in vitro from Clausena heptaphylla (Roxb.) W. & ARN: Isolation, structure and biological assay.J. Chem.2007411115
     [Google Scholar]
  54. LiL. ZhangS. XinY. SunJ. XieF. YangL. ChenZ. ChenH. LiuF. XuanY. YouZ. Role of Quzhou Fructus Aurantii extract in preventing and treating acute lung injury and inflammation.Sci. Rep.201881169810.1038/s41598‑018‑20083‑z 29374248
     [Google Scholar]
  55. LiL. ChenJ. LinL. PanG. ZhangS. ChenH. ZhangM. XuanY. WangY. YouZ. Quzhou Fructus Aurantii extract suppresses inflammation via regulation of MAPK, NF-κB, and AMPK signaling pathway.Sci. Rep.2020101159310.1038/s41598‑020‑58566‑7 32005962
     [Google Scholar]
  56. YouZ. ZhangS. QuX. WuY. LiY. WangY. ZhangW. The invention relates to the effective composition group of Fructus aurantii for treating viral pneumonia, preparation method and application thereof.Patent CN113577088A2021
     [Google Scholar]
  57. WuJ. HuangG. LiY. LiX. Flavonoids from Aurantii Fructus Immaturus and Aurantii Fructus: Promising phytomedicines for the treatment of liver diseases.Chin. Med.20201518910.1186/s13020‑020‑00371‑5 32863858
     [Google Scholar]
  58. WangY. LiuX.J. ChenJ.B. CaoJ.P. LiX. SunC.D. Citrus flavonoids and their antioxidant evaluation.Crit. Rev. Food Sci. Nutr.202262143833385410.1080/10408398.2020.1870035 33435726
     [Google Scholar]
  59. ZhengX. LiuC. WangD. BiX. YangB. SunC. Flavonoids contents and antioxidant activities in Citrus paradisi cv. Changshan Huyou during development.Acta Agriculturae Zhejiangensis20152711851191
     [Google Scholar]
  60. ZhangJ. SunC. YanY. ChenQ. LuoF. ZhuX. LiX. ChenK. Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells.Food Chem.201213531471147810.1016/j.foodchem.2012.06.004 22953882
     [Google Scholar]
  61. ZhengH. WangS. ZhongS. LouL. Extract of Citrus Changshan-Huyou, ameliorates renal oxidative damage in type 2 diabetic db/db mice.Zhejiang J. Integr. Tradit. Chin. West Med.202030105108
     [Google Scholar]
  62. RehmanK. MunawarS.M. AkashM.S.H. BuabeidM.A. ChohanT.A. TariqM. JabeenK. ArafaE.S.A. Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation.PLoS One2020151e022763710.1371/journal.pone.0227637 31929574
     [Google Scholar]
  63. YanJ. NieY. XuS. ZhangS. ChenZ. Pure total flavonoids from citrus alleviate oxidative stress and inflammation in nonalcoholic fatty liver disease by regulating the miR-137-3p/NOXA2/NOX2 pathway.Phytomedicine202311815494410.1016/j.phymed.2023.154944 37393830
     [Google Scholar]
  64. SlikaH. MansourH. WehbeN. NasserS.A. IratniR. NasrallahG. ShaitoA. GhaddarT. KobeissyF. EidA.H. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms.Biomed. Pharmacother.202214611244210.1016/j.biopha.2021.112442 35062053
     [Google Scholar]
  65. LiJ. WangT. LiuP. YangF. WangX. ZhengW. SunW. Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.Food Funct.20211293898391810.1039/D0FO02736G 33977953
     [Google Scholar]
  66. LiuX. JiangX. FangY. XiaD. WangS. ZhongS. Protective effect of total flavonoids from Fructus aurantii on lung injury of asthma mice infected with RSV through NF-κB signaling pathway.Zhejiang J. Integr. Tradit. Chin. West Med.20213133763380
     [Google Scholar]
  67. ZhangY. LuP. QinH. ZhangY. SunX. SongX. LiuJ. PengH. LiuY. NwaforE.O. LiJ. LiuZ. Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential.Biomed. Pharmacother.202113311107210.1016/j.biopha.2020.111072 33378971
     [Google Scholar]
  68. TanW. LiY. WangY. ZhangZ. WangT. ZhouQ. WangX. Anti-coagulative and gastrointestinal motility regulative activities of Fructus aurantii Immaturus and its effective fractions.Biomed. Pharmacother.20179024425210.1016/j.biopha.2017.03.060 28363170
     [Google Scholar]
  69. HuY. ChenH. SongY. TanS. LuoX. YangW. Study on the mechanism of Aurantii Fructus Immaturus and its main active ingredients in promoting gastrointestinal motility of model rats with spleen deficiency.China Pharmacy20172817471750
     [Google Scholar]
  70. YeY. HuS. XuX. YanF. QinL. ZhuB. Determination and correlation analysis of four flavonoid glycosides in Fructus aurantii and its related species.Zhejiang J. Integr. Tradit. Chin. West Med.202232752755
     [Google Scholar]
  71. LiuC. WangD. BiX. ZhengX. YangB. SunC. Determination of flavonoid content and antioxidant activity of ethanol extract from Pomelo chinensis.South China Fruits2015444144
     [Google Scholar]
  72. WangL. WangL. WuT. ZhaoS. ZhengM. LuS. Effects of different processing methods on the contents of the pharmacodynamic index components and antioxidant activity of Citrus aurantium.China Pharmacy202233830835
     [Google Scholar]
  73. FengJ. HuW. XuL. LiJ. WangS. SongJ. Simultaneous determination of the contents of 12 flavonoids in Quzhiqiao from different collection places by HPLC.China Pharmacy202031571575
     [Google Scholar]
  74. LiX. An Analysis of the Key Flavanone Componets and Their Content Variations in the Endemic Citrus Germplasm of China.Southwest University2011
     [Google Scholar]
  75. ZhuX. PanD. Comparative analysis of the contents of naringin, hesperidin and sypephrine in four kinds of Zhishi Chinese herbs. J Fujian Norm.Univ.2005019193
     [Google Scholar]
  76. MaY. ChenH. FangX. WangX. GeW. A comparative study on regulating qi effect of quzhiqiao (Fructus Aurantii from Zhejiang) and Fructus Aurantii from the other three major producing areas on functional dyspepsia rats.Chin J Tradit Med Sci Technol.202128722726
     [Google Scholar]
  77. GeY. MaY. ZhaoM. WeiJ. WuX. ZhangZ. YangH. LeiH. WuB. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches.Eur. J. Med. Chem.202224211469910.1016/j.ejmech.2022.114699 36001934
     [Google Scholar]
  78. GeY. ZhouC. MaY. WangZ. WangS. WangW. WuB. Advancing natural product discovery: A structure-oriented fractions screening platform for compound annotation and isolation.Anal. Chem.202496145399540610.1021/acs.analchem.3c05057 38523322
     [Google Scholar]
  79. SissiS. LoubnaA. OuhaddouS. AhmedO. LarhsiniM. MarkoukM. In vitro antioxidant potential and in vivo analgesic and anti-inflammatory activities of Moroccan Equisetum ramosissimum.Nat. Prod. J.2023134859
     [Google Scholar]
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A Comprehensive Review on the Chinese Herbal Medicine Quzhiqiao
Natural Products Journal, The 16, e22103155353712 (2026); https://doi.org/10.2174/0122103155353712241008060527
/content/journals/npj/10.2174/0122103155353712241008060527
/content/journals/npj/10.2174/0122103155353712241008060527
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  • Article Type:     Review Article
Keyword(s): Chinese herbal medicine; Citrus aurantiun; curative effects; flavonoids; Quzhiqiao

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