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image of Polyene Macrolactams from Marine Micromonospora sp.

Abstract

Introduction

Three novel macrolactams, FW8-1 (), FW8-4 (), and FW60-20 (), were isolated from a culture of sp. The structures of these compounds were elucidated using Mass Spectrometry (MS) and comprehensive Nuclear Magnetic Resonance (NMR) analyses.

Methods

The relative configurations of compounds - were assigned through theoretical calculations of their NMR spectra.

Results

The isolation and determination of the relative configurations of these macrolactams have provided fresh perspectives on the biosynthetic pathways, leading to the formation of polyene macrolactams.

Conclusion

Further, virtual screening and bioactivity predictions have suggested compounds - to possess potential anti-tumor, anti-inflammatory, and neuroprotective properties.

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2024-10-11
2024-11-23

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Polyene Macrolactams from Marine Micromonospora sp.
Bentham Science Publishers ; https://doi.org/10.2174/0122103155340964241009112348
/content/journals/npj/10.2174/0122103155340964241009112348
/content/journals/npj/10.2174/0122103155340964241009112348
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  • Article Type:     Research Article
Keywords: theoretical calculations ; biosynthetic mechanism ; Micromonospora sp. ; Polyene macrolactams

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