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image of Inflammation and Cancer Development: Basic Mechanisms and Evidence of its Regulation by Hibiscus sabdariffa Natural Extracts

Abstract

Background

is a plant used in traditional medicine for intestinal treatments and nowadays for critical diseases like hypertension, diabetes, and cancer. Multidisciplinary approaches have demonstrated, through extracts, anti-inflammation and anti-cancer beneficial properties from compounds like phenols, flavonoids, and anthocyanins that are ubiquitously distributed in whole plants.

Objective

The objective of this study is to identify the bioactive compounds and their underlying mechanisms of action that drive the anti-cancer and anti-inflammatory properties of extracts.

Methods

We searched databases for publications in English from all years that reported beneficial anti-inflammation and anti-cancer properties from extracts and their proposed mechanism of action. We used Pubmed, Google Scholar, Scopus, and ScienceDirect for original articles that included different extracts evaluated for their anti-inflammation, and anti-cancer properties, using the following search terms: “ extracts”, and inflammation”, and “ and cancer”. Some articles from the reference list were used to collect additional information, and we used 73 articles in total.

Results

In general, extracts from are obtained by different methods that affect the final concentration of the compounds. Several and show their anti-inflammatory and anti-cancer properties.

Conclusion

extracts have the potential bioactivity to modulate inflammation and cancer in several cellular and molecular mechanisms of action involving the downregulation of key signaling pathways such as NFκB, MAPK, BCL-2, p53, among others, and the upregulation of protective pathways such as Nrf2. However, research needs to be further evaluated on the exact compounds that have this effect, in order to know if the extracts work individually or synergistically.

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2025-01-21
2025-06-19

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/content/journals/npj/10.2174/0122103155352510241218055748
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Inflammation and Cancer Development: Basic Mechanisms and Evidence of its Regulation by Hibiscus sabdariffa Natural Extracts
Bentham Science Publishers ; https://doi.org/10.2174/0122103155352510241218055748
/content/journals/npj/10.2174/0122103155352510241218055748
/content/journals/npj/10.2174/0122103155352510241218055748
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  • Article Type:     Review Article
Keywords: Hibiscus sabdariffa ; mechanism of action ; anti-cancer properties ; bioactive compounds ; inflammation ; cancer

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