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2000
Volume 16, Issue 3
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Background

is a plant used in traditional medicine for intestinal treatments and nowadays for critical diseases like hypertension, diabetes, and cancer. Multidisciplinary approaches have demonstrated, through extracts, anti-inflammation and anti-cancer beneficial properties from compounds like phenols, flavonoids, and anthocyanins that are ubiquitously distributed in whole plants.

Objective

The objective of this study is to identify the bioactive compounds and their underlying mechanisms of action that drive the anti-cancer and anti-inflammatory properties of extracts.

Methods

We searched databases for publications in English from all years that reported beneficial anti-inflammation and anti-cancer properties from extracts and their proposed mechanism of action. We used PubMed, Google Scholar, Scopus, and ScienceDirect for original articles that included different extracts evaluated for their anti-inflammation, and anti-cancer properties, using the following search terms: “ extracts”, and inflammation”, and “ and cancer”. Some articles from the reference list were used to collect additional information, and we used 73 articles in total.

Results

In general, extracts from are obtained by different methods that affect the final concentration of the compounds. Several and experiments show their anti-inflammatory and anti-cancer properties.

Conclusion

extracts have the potential bioactivity to modulate inflammation and cancer in several cellular and molecular mechanisms of action involving the downregulation of key signaling pathways such as NFκB, MAPK, BCL-2, p53, among others, and the upregulation of protective pathways such as Nrf2. However, research needs to be further evaluated on the exact compounds that have this effect, in order to know if the extracts work individually or synergistically.

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References

  1. RanjanS. Hibiscus sabdariffa -Roselle.201921527
     [Google Scholar]
  2. SuliemanA.M.E. Antimicrobial activity of Roselle (Hibiscus sabdariffa L.) seed oil. In: Multiple Biological Activities of Unconventional Seed Oils.Elsevier20229110010.1016/B978‑0‑12‑824135‑6.00003‑9
     [Google Scholar]
  3. OnyenekweP.C. AjaniE.O. AmehD.A. GamanielK.S. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats.Cell Biochem. Funct.199917319920610.1002/(SICI)1099‑0844(199909)17:3<199:AID‑CBF829>3.0.CO;2‑2 10451541
     [Google Scholar]
  4. Salazar-GonzálezC. Vergara-BalderasF.T. Ortega-RegulesA.E. -Beltrán, J.Á. Antioxidant properties and color of Hibiscus sabdariffa extracts.Cienc. Investig. Agrar.2012391799010.4067/S0718‑16202012000100006
     [Google Scholar]
  5. ParaísoC.M. Dos SantosS.S. Langer OgawaC.Y. SatoF. SantosO.A.A. MadronaG.S. Hibiscus sabdariffa L. Extract: Characterization (FTIR-ATR), Storage Stability and Food Application.Emir. J. Food Agric.20205510.9755/ejfa.2020.v32.i1.2059
     [Google Scholar]
  6. SinghM. ThrimawithanaT. ShuklaR. AdhikariB. Extraction and characterization of polyphenolic compounds and potassium hydroxycitrate from Hibiscus sabdariffa.Future Foods2021410008710.1016/j.fufo.2021.100087
     [Google Scholar]
  7. MacielL.G. do CarmoM.A.V. AzevedoL. DaguerH. MolognoniL. de AlmeidaM.M. GranatoD. RossoN.D. Hibiscus sabdariffa anthocyanins-rich extract: Chemical stability, in vitro antioxidant and antiproliferative activities.Food Chem. Toxicol.201811318719710.1016/j.fct.2018.01.053 29407472
     [Google Scholar]
  8. GhellerA.C.G.V. KerkhoffJ. Vieira JúniorG.M. de CamposK.E. SuguiM.M. Antimutagenic Effect of Hibiscus sabdariffa L. Aqueous Extract on Rats Treated with Monosodium Glutamate.ScientificWorldJournal2017201719392532 28197528
     [Google Scholar]
  9. PutraIB. SoebonoH. HadisahputraS. BachtiarA. The Effect of Roselle (Hibiscus sabdariffa L.) Flowers Extract on the Apoptosis of Fibroblast Proliferation in Keloids.Open Access Maced. J. Med. Sci.20208A6114
     [Google Scholar]
  10. JoshuaM. OkereC. SylvesterO.D. YahayaM. PreciousO. DluyaT. UmJ.Y. NeksumiM. BoydJ. Vincent-TyndallJ. ChooD.W. GutsaevaD.R. JahngW.J. Disruption of Angiogenesis by Anthocyanin-Rich Extracts of Hibiscus sabdariffa.Int. J. Sci. Eng. Res.20178229930710.14299/ijser.2017.02.009 28459020
     [Google Scholar]
  11. HuangC.C. HungC.H. ChenC.C. KaoS.H. WangC.J. Hibiscus sabdariffa polyphenol-enriched extract inhibits colon carcinoma metastasis associating with FAK and CD44/c-MET signaling.J. Funct. Foods20184854255010.1016/j.jff.2018.07.055
     [Google Scholar]
  12. FormagioA.S.N. RamosD.D. VieiraM.C. RamalhoS.R. SilvaM.M. ZárateN.A.H. FoglioM.A. CarvalhoJ.E. Phenolic compounds of Hibiscus sabdariffa and influence of organic residues on its antioxidant and antitumoral properties.Braz. J. Biol.2015751697610.1590/1519‑6984.07413 25945622
     [Google Scholar]
  13. MalacridaA. ErriquezJ. HashemiM. Rodriguez-MenendezV. CassettiA. CavalettiG. MilosoM. Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells.Biochem. Biophys. Rep.20223210135310.1016/j.bbrep.2022.101353 36186735
     [Google Scholar]
  14. KhaghaniS. RaziF. YajlooM.M. PaknejadM. ShariftabriziA. PasalarP. Selective Cytotoxicity and Apoptogenic Activity of Hibiscus sabdariffa Aqueous Extract Against MCF-7 Human Breast Cancer Cell Line.J. Cancer Ther.20112339440010.4236/jct.2011.23054
     [Google Scholar]
  15. MillanZ.E. García-GarciaM.R. LeyvaJ.G. MartinezR.F. VitalJ.A.V. GarcíaE.H. Lyophilized Extract of Hibiscus sabdariffa L. Induces Cytotoxicity in Breast Cancer Cell Lines.Proceedings.202061122
     [Google Scholar]
  16. AdemiluyiA.O. AkinyemiA.J. ObohG. AgbebiO.J. Anthocyanin - Rich Red Dye of Hibiscus sabdariffa Calyx Modulates Cisplatin-induced Nephrotoxicity and Oxidative Stress in Rats.Int. J. Biomed. Sci.20139424324810.59566/IJBS.2013.9243 24711761
     [Google Scholar]
  17. GradinaruG. BiliaderisC.G. KallithrakaS. KefalasP. Garcia-VigueraC. Thermal stability of Hibiscus sabdariffa L. anthocyanins in solution and in solid state: effects of copigmentation and glass transition.Food Chem.200383342343610.1016/S0308‑8146(03)00125‑0
     [Google Scholar]
  18. Apáez-BarriosP. Pedraza-SantosM.E. Rodríguez-MendozaM.N. Raya-MontañoY.A. Jaén-ContrerasD. Yield and anthocyanin concentration in Hibiscus sabdariffa L. with foliar application of micronutrients.Chapingo Magazine. Horticulture Series2018XXIV210.5154/r.rchsh.2017.06.020
     [Google Scholar]
  19. WidowatiW. RaniA.P. HamzahR.A. ArumwardanaS. AfifahE. KusumaH.S.W. RihibihaD.D. NufusH. AmaliaA. Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds.Nat. Prod. Sci.201723319220010.20307/nps.2017.23.3.192
     [Google Scholar]
  20. YagiS. UbaA.I. SinanK.I. PiattiD. SagratiniG. CaprioliG. EltiganiS.M. LazarovaI. ZenginG. Comparative Study on the Chemical Profile, Antioxidant Activity, and Enzyme Inhibition Capacity of Red and White Hibiscus sabdariffa Variety Calyces.ACS Omega2023845425114252110.1021/acsomega.3c05217 38024777
     [Google Scholar]
  21. DesmiatyY. AlatasF. Determination of quercetin in Hibiscus sabdariffa L. Calyces by High-Performance Liquid Chromatography (HPLC).Proceeding of the International Seminar on Chemistry2008
     [Google Scholar]
  22. MajdoubY.O.E. GinestraG. MandalariG. DugoP. MondelloL. CacciolaF. The Digestibility of Hibiscus sabdariffa L. Polyphenols Using an in vitro Human Digestion Model and Evaluation of Their Antimicrobial Activity.Nutrients2021137236010.3390/nu13072360 34371869
     [Google Scholar]
  23. JabeurI. PereiraE. BarrosL. CalhelhaR.C. SokovićM. OliveiraM.B.P.P. FerreiraI.C.F.R. Hibiscus sabdariffa L. as a source of nutrients, bioactive compounds and colouring agents.Food Res. Int.2017100Pt 171772310.1016/j.foodres.2017.07.073 28873741
     [Google Scholar]
  24. SindiH.A. MarshallL.J. MorganM.R.A. Comparative chemical and biochemical analysis of extracts of Hibiscus sabdariffa.Food Chem.2014164232910.1016/j.foodchem.2014.04.097 24996300
     [Google Scholar]
  25. ObouayebaA.P. DjyhB. DiabateS. DjamanJ. Jean DavidN. KonéM. Phytochemical and antioxidant activity of Roselle (Hibiscus sabdariffa L.) petal extracts.Res. J. Pharm. Biol. Chem. Sci.2014514531465
     [Google Scholar]
  26. FitrotunnisaQ. ArsiantiA. TejaputriNA. QorinaF. Antioxidative activity and phytochemistry profile of Hibiscus sabdariffa Herb extracts.Int. J. App. Pharm.20192932
     [Google Scholar]
  27. Al-HashimiA. Antioxidant and antibacterial activities of Hibiscus sabdariffa L. extracts.201250611
     [Google Scholar]
  28. Gurrola-DíazC.M. García-LópezP.M. Sánchez-EnríquezS. Troyo-SanrománR. Andrade-GonzálezI. Gómez-LeyvaJ.F. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy).Phytomedicine201017750050510.1016/j.phymed.2009.10.014 19962289
     [Google Scholar]
  29. Pacheco CoelloF. Orosco-VargasC. Peraza-MarreroM. Pinto-CatariI. Ramirez-AzuajeD. Effect of an extract of Hibiscus sabdariffa L., on oxidative stress induced in Saccharomyces cerevisiae.Ciencia Ambiente y Clima2020314146
     [Google Scholar]
  30. ShenC.Y. ZhangT.T. ZhangW.L. JiangJ.G. Anti-inflammatory activities of essential oil isolated from the calyx of Hibiscus sabdariffa L.Food Funct.20167104451445910.1039/C6FO00795C 27713954
     [Google Scholar]
  31. JuZ. LiM. XuJ. HowellD.C. LiZ. ChenF.E. Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years.Acta Pharm. Sin. B20221262790280710.1016/j.apsb.2022.01.002 35755295
     [Google Scholar]
  32. LiuT. ZhangL. JooD. SunS.C. NF-κB signaling in inflammation.Signal Transduct. Target. Ther.2017211702310.1038/sigtrans.2017.23 29158945
     [Google Scholar]
  33. LiX. LiC. ZhangW. WangY. QianP. HuangH. Inflammation and aging: signaling pathways and intervention therapies.Signal Transduct. Target. Ther.20238123910.1038/s41392‑023‑01502‑8 37291105
     [Google Scholar]
  34. SogoT. TeraharaN. HisanagaA. KumamotoT. YamashiroT. WuS. SakaoK. HouD.X. Anti‐inflammatory activity and molecular mechanism of delphinidin 3‐sambubioside, a Hibiscus anthocyanin.Biofactors2015411586510.1002/biof.1201 25728636
     [Google Scholar]
  35. ZhaoH. WuL. YanG. ChenY. ZhouM. WuY. LiY. Inflammation and tumor progression: signaling pathways and targeted intervention.Signal Transduct. Target. Ther.20216126310.1038/s41392‑021‑00658‑5 34248142
     [Google Scholar]
  36. van LooG. BertrandM.J.M. Death by TNF: a road to inflammation.Nat. Rev. Immunol.202323528930310.1038/s41577‑022‑00792‑3 36380021
     [Google Scholar]
  37. MitchellJ.P. CarmodyR.J. NF-κB and the Transcriptional Control of Inflammation.Int. Rev. Cell Mol. Biol.2018335418410.1016/bs.ircmb.2017.07.007 29305014
     [Google Scholar]
  38. MohsinN-A. IrfanM. Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities.Med. Chem. Res.202029580983010.1007/s00044‑020‑02528‑1
     [Google Scholar]
  39. KaminskaB. MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits.Biochim. Biophys. Acta. Proteins Proteomics200517541-225326210.1016/j.bbapap.2005.08.017 16198162
     [Google Scholar]
  40. KimE.K. ChoiE.J. Pathological roles of MAPK signaling pathways in human diseases.Biochim. Biophys. Acta Mol. Basis Dis.20101802439640510.1016/j.bbadis.2009.12.009 20079433
     [Google Scholar]
  41. SaklatvalaJ. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.Curr. Opin. Pharmacol.20044437237710.1016/j.coph.2004.03.009 15251131
     [Google Scholar]
  42. PapiS. AhmadizarF. HasanvandA. The role of nitric oxide in inflammation and oxidative stress.Immunopathologia Persa201951e08e0810.15171/ipp.2019.08
     [Google Scholar]
  43. SpillerF. Oliveira FormigaR. Fernandes da Silva CoimbraJ. Alves-FilhoJ.C. CunhaT.M. CunhaF.Q. Targeting nitric oxide as a key modulator of sepsis, arthritis and pain.Nitric Oxide201989324010.1016/j.niox.2019.04.011 31051258
     [Google Scholar]
  44. LubisM. SiregarG.A. BangunH. IlyasS. The effect of roselle flower petals extract (Hibiscus sabdariffa Linn.) on reducing inflammation in dextran sodium sulfateinduced colitis.Med. Glas.202017239540110.17392/1095‑20 32329325
     [Google Scholar]
  45. JovenJ. MarchI. EspinelE. Fernández-ArroyoS. Rodríguez-GallegoE. AragonèsG. Beltrán-DebónR. Alonso-VillaverdeC. RiosL. Martin-ParederoV. MenendezJ.A. MicolV. Segura-CarreteroA. CampsJ. Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function.Mol. Nutr. Food Res.20145861374137810.1002/mnfr.201300774 24668839
     [Google Scholar]
  46. PrasomthongJ. LimpeanchobN. DaodeeS. ChonpathompikunlertP. TunsophonS. Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet.Sci. Rep.2022121702210.1038/s41598‑022‑11027‑9 35487948
     [Google Scholar]
  47. Beltrán-DebónR. Alonso-VillaverdeC. AragonèsG. Rodríguez-MedinaI. RullA. MicolV. Segura-CarreteroA. Fernández-GutiérrezA. CampsJ. JovenJ. The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans.Phytomedicine2010173-418619110.1016/j.phymed.2009.08.006 19765963
     [Google Scholar]
  48. AbakerA.O. Chemopreventive Effect of Hibiscus sabdariffa Calyx Anthocyanins and Nanoselenium against N-Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats.Egyptian J. Pure Appl. Sci.2015533233310.21608/ejaps.2015.184782
     [Google Scholar]
  49. DidierA.J. StieneJ. FangL. WatkinsD. DworkinL.D. CreedenJ.F. Antioxidant and Anti-Tumor Effects of Dietary Vitamins A, C, and E.Antioxidants202312363210.3390/antiox12030632 36978880
     [Google Scholar]
  50. LinH.H. HuangH.P. HuangC.C. ChenJ.H. WangC.J. Hibiscus polyphenol‐rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway.Mol. Carcinog.2005432869910.1002/mc.20103 15791651
     [Google Scholar]
  51. JiangM. QiL. LiL. LiY. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer.Cell Death Discov.20206111210.1038/s41420‑020‑00349‑0 33133646
     [Google Scholar]
  52. WeiX. XieF. ZhouX. WuY. YanH. LiuT. HuangJ. WangF. ZhouF. ZhangL. Role of pyroptosis in inflammation and cancer.Cell. Mol. Immunol.202219997199210.1038/s41423‑022‑00905‑x 35970871
     [Google Scholar]
  53. YueJ. LópezJ.M. Understanding MAPK Signaling Pathways in Apoptosis.Int. J. Mol. Sci.2020217234610.3390/ijms21072346 32231094
     [Google Scholar]
  54. TsaiM.C. ChenC.C. TsengT.H. ChangY.C. LinY.J. TsaiI.N. WangC.C. WangC.J. Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.Nutrients20231518397210.3390/nu15183972 37764756
     [Google Scholar]
  55. PrabhakaranD. SenthamilselviM.M. RajeshkannaA. Anticancer Activity of Hibiscus sabdariffa.L(Flowers) against Human Liver Cancer (Hepg2) Cell Line.Int. J. Chemtech Res.2017
     [Google Scholar]
  56. AnggiV. PatalaR. ArfiahA. DewiN.P. Anticancer Activity of Rosella Flowers (Hibiscus Sabdariffa l.) in HepG2 cells.J. Sci. Educ. Res.20239698703
     [Google Scholar]
  57. FithrotunnisaQ. ArsiantiA. KurniawanG. QorinaF. TejaputriN.A. AzizahN.N. In vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A549 Lung Cancer Cell Line.Pharmacogn. J.20201211419
     [Google Scholar]
  58. MalacridaA. CavalloroV. MartinoE. CostaG. AmbrosioF.A. AlcaroS. RigolioR. CassettiA. MilosoM. CollinaS. Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa—Part 2.Molecules20212621659610.3390/molecules26216596 34771006
     [Google Scholar]
  59. SehimA.E. AminB.H. YosriM. SalamaH.M. AlkhalifahD.H. AlwailiM.A. Abd ElghaffarR.Y.G.C-MS Analysis, Antibacterial, and Anticancer Activities of Hibiscus sabdariffa L. methanolic extract: in vitro and in silico studies.Microorganisms2023116160110.3390/microorganisms11061601 37375103
     [Google Scholar]
  60. SobantuM.P. OkeleyeB.I. OkudohV.I. MeyerM. AbouaY.G. In Vitro Antioxidant Mechanism of Action of Hibiscus sabdariffa in the Induction of Apoptosis against Breast Cancer.J. Herbs Spices Med. Plants202329321322810.1080/10496475.2022.2135661
     [Google Scholar]
  61. BassongT.R. KenmogneL.V. AwounfackC.F. NdintehD.T. NjamenD. ZingueS. Effects of Hibiscus sabdariffa Calyxes Aqueous Extract on Antioxidant Status and Histopathology in Mammary Tumor-Induced in Rats.Evid. Based Complement. Alternat. Med.20222022111310.1155/2022/9872788 35502172
     [Google Scholar]
  62. IslamM. HasiR.Y. AliH. KarmakarP.C. HabibR. SatterM.A. Antioxidant and antineoplastic activities of leaves of Hibiscus sabdariffa Lina against Ehrlich ascites carcinoma cells in Swiss albino mice : Natural anticancer agents.Bangladesh Med. Res. Counc. Bull.202147215616410.3329/bmrcb.v47i2.57774
     [Google Scholar]
  63. YeasminT. AliH. YesminR. IslamM. HoshenA. HabibR. SatterM.A. HaqueK.M.F. Growth Inhibition and Apoptosis of Ehrlich Ascites Carcinoma Cells by Methanol Extract from the Calyx of Hibiscus sabdariffa Linn.Central Asian J. Med. Sci.20184215516510.24079/cajms.2018.06.007
     [Google Scholar]
  64. NguyenC. BaskaranK. PupulinA. RuvinovI. ZaitoonO. GrewalS. ScariaB. MehaidliA. VeghC. PandeyS. Hibiscus flower extract selectively induces apoptosis in breast cancer cells and positively interacts with common chemotherapeutics.BMC Complement. Altern. Med.20191919810.1186/s12906‑019‑2505‑9 31060537
     [Google Scholar]
  65. SuC.C. WangC.J. HuangK.H. LeeY.J. ChanW.M. ChangY.C. Anthocyanins from Hibiscus sabdariffa calyx attenuate in vitro and in vivo melanoma cancer metastasis.J. Funct. Foods20184861463110.1016/j.jff.2018.07.032
     [Google Scholar]
  66. WuC.H. HuangC.C. HungC.H. YaoF.Y. WangC.J. ChangY.C. Delphinidin-rich extracts of Hibiscus sabdariffa L. trigger mitochondria-derived autophagy and necrosis through reactive oxygen species in human breast cancer cells.J. Funct. Foods20162527929010.1016/j.jff.2016.05.018
     [Google Scholar]
  67. TsaiT.C. HuangH.P. ChangY.C. WangC.J. An anthocyanin-rich extract from Hibiscus sabdariffa linnaeus inhibits N-nitrosomethylurea-induced leukemia in rats.J. Agric. Food Chem.20146271572158010.1021/jf405235j 24471438
     [Google Scholar]
  68. LinH.H. ChenJ.H. WangC.J. Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne.Curr. Med. Chem.20111881245125410.2174/092986711795029663 21291361
     [Google Scholar]
  69. BayaniG.F.E. MarpaungN.L.E. SimorangkirD.A.S. SianiparI.R. IbrahimN. KartinahN.T. MansurI.G. PurbaJ.S. IlyasE.I.I. Anti-inflammatory Effects of Hibiscus sabdariffa Linn. on the IL-1β/IL-1ra Ratio in Plasma and Hippocampus of Overtrained Rats and Correlation with Spatial Memory.Kobe J. Med. Sci.2018642E73E83 30381729
     [Google Scholar]
  70. ZhenJ. VillaniT.S. GuoY. QiY. ChinK. PanM.H. HoC.T. SimonJ.E. WuQ. Phytochemistry, antioxidant capacity, total phenolic content and anti-inflammatory activity of Hibiscus sabdariffa leaves.Food Chem.201619067368010.1016/j.foodchem.2015.06.006 26213025
     [Google Scholar]
  71. ChouS.T. LoH.Y. LiC.C. ChengL.C. ChouP.C. LeeY.C. HoT.Y. HsiangC.Y. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation.J. Ethnopharmacol.201619461762510.1016/j.jep.2016.10.059 27773797
     [Google Scholar]
  72. AbubakarS.M. UkeyimaM.T. SpencerJ.P.E. LovegroveJ.A. Acute Effects of Hibiscus sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans.Nutrients201911234110.3390/nu11020341 30764582
     [Google Scholar]
  73. LiangC.C. ParkA.Y. GuanJ.L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.Nat. Protoc.20072232933310.1038/nprot.2007.30 17406593
     [Google Scholar]
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Inflammation and Cancer Development: Basic Mechanisms and Evidence of its Regulation by Hibiscus sabdariffa Natural Extracts
Natural Products Journal, The 16, e22103155352510 (2026); https://doi.org/10.2174/0122103155352510241218055748
/content/journals/npj/10.2174/0122103155352510241218055748
/content/journals/npj/10.2174/0122103155352510241218055748
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  • Article Type:     Review Article
Keyword(s): anti-cancer properties; bioactive compounds; cancer; Hibiscus sabdariffa; inflammation; mechanism of action

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