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image of Phytochemical Characterization of the Aerial Parts of Teucrium nuchense K. Koch: An Endemic Species of Caucasian Flora

Abstract

Background

The genus L. is frequently employed in traditional medicine, primarily for addressing disorders of the digestive and respiratory systems. Biological investigations focused on essential oils have substantiated their antibacterial, antioxidant, anti-tumor, anti-diabetic, and anti-rheumatic properties.

Objective

The aim of the study was to assess the chemical composition and biological activities of the aerial parts of the endemic species K. Koch.

Methods

The chemical composition of the essential oil was analyzed using gas chromatography-mass spectrometry (GC-MS). The antioxidant activity was evaluated through the Oxygen Radical Absorbance Capacity (ORAC) assay and tested on normal skin fibroblasts (WS-1). Additionally, the anti-inflammatory efficacy was assessed by monitoring nitric oxide production. The total phenolic content in the aqueous, methanolic, and chloroformic extracts was quantified using the Folin-Ciocalteu reagent. Individual compounds were isolated using preparative high-performance liquid chromatography. Their identification was accomplished using high-resolution mass spectrometry (HRMS) with an ESI-Q-TOF detector in conjunction with nuclear magnetic resonance (NMR) spectroscopy.

Results

The essential oil yield was 0.32 ml/kg. Caryophyllene oxide, constituting 15.19%, and 1-octen-3-ol, constituting 8.75%, emerged as the primary components in the essential oil. Oxygenated sesquiterpenes dominated the terpenic compounds, representing 25.1% of the essential oil. The aqueous and methanolic extracts displayed a notable phenolic content, with percentages of 27 ± 2% and 35 ± 0.1%, respectively. Both the aqueous and methanolic extracts demonstrated robust antioxidant activity in the ORAC test and assessments using WS-1 cells. The methanolic extract, at a concentration of 160 μg/ml, inhibited NO formation by 90%, without toxicity in RAW 264.7. Individual compounds, teucrioside from the phenylethanoid glycoside class, two neo-clerodane diterpenes, teucrin A, and 6-alpha-hydroxyteuscordine, were isolated.

Conclusion

The essential oil extracted from the aerial parts of is characterized by the presence of caryophyllene oxide and 1-octen-3-ol. The methanolic extract exhibits notable antioxidant as well as anti-inflammatory properties, whereas the aqueous extract demonstrates high antioxidant activity. Additionally, three compounds of teucrioside, teucrin A, and 6-α-hydroxyteuscordine have been isolated and characterized.

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2024-09-05
2024-11-23

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References

  1. Abdullah F.O. Hussain F.H.S. Sardar A.S. Gilardoni G. Thu Z.M. Vidari G. Bio-active compounds from Teucrium plants used in the traditional medicine of Kurdistan Region, Iraq. Molecules 2022 27 10 3116 10.3390/molecules27103116 35630593
    [Google Scholar]
  2. Ciocarlan A. Dragalin I. Aricu A. Lupascu L. Ciocarlan N. Vergel K. Chemical profile, elemental composition, and antimicrobial activity of plants of the teucrium (Lamiaceae) genus growing in moldova. J. Agron. 2022 12 4 772
    [Google Scholar]
  3. Catinella G. Badalamenti N. Ilardi V. Rosselli S. De Martino L. Bruno M. The essential oil compositions of three Teucrium taxa growing wild in sicily: HCA and PCA analyses. Molecules 2021 26 3 643 10.3390/molecules26030643 33530639
    [Google Scholar]
  4. Stanković M. Teucrium Species: Biology and Applications. Cham Springer International Publishing 2020 10.1007/978‑3‑030‑52159‑2
    [Google Scholar]
  5. Debbabi H. El Mokni R. Jlassi I. Joshi R.K. Hammami S. Chemical composition and antimicrobial activity of Teucrium Capitatum L. Subsp. Lusitanicum (Schreb.) T. Navarro & Rosua essential oil. J. Chromatogr. Sci. 2021 59 2 134 139 10.1093/chromsci/bmaa086 33230534
    [Google Scholar]
  6. Maccioni A. Falconieri D. Sanna C. Porcedda S. Piras A. Maxia A. Characterization of essential oils from different taxa belonging to the genus Teucrium in Sardinia Island, Italy. Plants 2021 10 7 1359 10.3390/plants10071359 34371562
    [Google Scholar]
  7. Formisano C. Napolitano F. Rigano D. Arnold N.A. Piozzi F. Senatore F. Essential oil composition of Teucrium divaricatum Sieb. ssp. villosum (Celak.) Rech. fil. growing wild in Lebanon. J. Med. Food 2010 13 5 1281 1285 10.1089/jmf.2009.0216 20626245
    [Google Scholar]
  8. Ruiters A.K. Tilney P.M. Van Vuuren S.F. Viljoen A.M. Kamatou G.P.P. Van Wyk B.E. The anatomy, ethnobotany, antimicrobial activity and essential oil composition of southern African species of Teucrium (Lamiaceae). S. Afr. J. Bot. 2016 102 175 185 10.1016/j.sajb.2015.06.008
    [Google Scholar]
  9. Muselli A. Desjobert J.M. Paolini J. Bernardini A.F. Costa J. Rosa A. Dessi M.A. Chemical composition of the essential oils of Teucrium chamaedrys L. from Corsica and Sardinia. J. Essent. Oil Res. 2009 21 2 138 143 10.1080/10412905.2009.9700133
    [Google Scholar]
  10. Lazović M. Cvijetić I. Jankov M. Milojković-Opsenica D. Trifković J. Ristivojević P. COSMO-RS in prescreening of natural eutectic solvents for phenolic extraction from Teucrium chamaedrys. J. Mol. Liq. 2023 387 122649 10.1016/j.molliq.2023.122649
    [Google Scholar]
  11. Lazović M. Cvijetić I. Trifković J. Agatonović-Kuštrin S. Morton D. Ristivojević P. Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: A greenness assessment by the National Environmental Methods Index and analytical eco-scale. J. Planar Chromatogr. Mod. TLC 2023 36 351 358
    [Google Scholar]
  12. Al-Naemi H.A. Alasmar R.M. Al-Ghanim K. Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study. Biomol. Biomed. 2024 24 1 82 88
    [Google Scholar]
  13. Bahramikia S. Yazdanparast R. Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae). Phytother. Res. 2012 26 11 1581 1593 10.1002/ptr.4617 22344867
    [Google Scholar]
  14. Sharififar F. Dehghn-Nudeh G. Mirtajaldini M. Major flavonoids with antioxidant activity from Teucrium polium L. Food Chem. 2009 112 4 885 888 10.1016/j.foodchem.2008.06.064
    [Google Scholar]
  15. Elbermawi A. Zulfiqar F. Khan I.A. Ali Z. Fatimanols Y and Z: Two neo -clerodane diterpenoids from Teucrium yemense. RSC Advances 2023 13 43 30264 30268 10.1039/D3RA06083G 37868827
    [Google Scholar]
  16. Rehman I. Gondal H.Y. Zamir R. Al-Hussain S.A. Batool F. Irfan A. Noreen S. Roheen T. Nisar M. Zaki M.E.A. Green synthesis: The antibacterial and photocatalytic potential of silver nanoparticles using extract of Teucrium stocksianum. Nanomaterials (Basel) 2023 13 8 1343 10.3390/nano13081343 37110928
    [Google Scholar]
  17. Keller M. Chabane S. Boudjelal A. Danton O. Prescimone A. Hamburger M. Potterat O. New neo-clerodane diterpenes from Teucrium polium subsp. capitatum. J. Mol. Struct. 2023 1284 135447 10.1016/j.molstruc.2023.135447
    [Google Scholar]
  18. Polat E.B. Hazar-Yavuz A.N. Guler E. Ozcan G.S. Taskin T. Duruksu G. Elcioglu H.K. Yazır Y. Cam M.E. Sublingual administration of teucrium polium-loaded nanofibers with ultra-fast release in the treatment of diabetes mellitus: In vitro and in vivo evaluation. J. Pharm. Sci. 2024 113 4 1068 1087 10.1016/j.xphs.2023.12.013 38123068
    [Google Scholar]
  19. Stanković M.S. Zlatić N.M. Ethnobotany of Teucrium Species. 2018
    [Google Scholar]
  20. Kremer D. Kosir I. Kosalec I. Koncic M. Potocnik T. Cerenak A. Bezic N. Srecec S. Dunkic V. Investigation of chemical compounds, antioxidant and antimicrobial properties of teucrium arduini L. (lamiaceae). Curr. Drug Targets 2013 14 9 1006 1014 10.2174/1389450111314090009 23597042
    [Google Scholar]
  21. Sadeghi Z. Yang J.L. Venditti A. Moridi Farimani M. A review of the phytochemistry, ethnopharmacology and biological activities of Teucrium genus (Germander). Nat. Prod. Res. 2022 36 21 5647 5664 10.1080/14786419.2021.2022669 34986708
    [Google Scholar]
  22. Menichini F. Conforti F. Rigano D. Formisano C. Piozzi F. Senatore F. Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece. Food Chem. 2009 115 2 679 686 10.1016/j.foodchem.2008.12.067
    [Google Scholar]
  23. Majdoub S. Dall’Acqua S. El Mokni R. Hammami S. Peron G. Chemical composition and antioxidant activity of essential oil from the aerial parts of Teucrium luteum (Mill.) Degen subsp. flavovirens (Batt.) Greuter & Burdet growing wild in Tunisia. Appl. Sci. (Basel) 2022 12 15 7370 10.3390/app12157370
    [Google Scholar]
  24. Mannan A. Mannan, A. Insulinotropic effect of Teucrium polium; Identification of potential mechanistic drug targets. In: Adv. Med. Plant Res;, 2024; 12, pp. (1)18-32.
    [Google Scholar]
  25. Djilas S.M. Markov S.L. Cvetković D.D. Čanadanović-Brunet J.M. Ćetković G.S. Tumbas V.T. Antimicrobial and free radical scavenging activities of Teucrium montanum. Fitoterapia 2006 77 5 401 403 10.1016/j.fitote.2006.05.019 16797876
    [Google Scholar]
  26. Blowman K. Magalhães M. Lemos M.F.L. Cabral C. Pires I.M. Anticancer properties of essential oils and other natural products. 2018
    [Google Scholar]
  27. Dunkić V. Bezić N. Vuko E. Antiphytoviral activity of essential oil from endemic species Teucrium arduini. 2011
    [Google Scholar]
  28. Ali N. Chhetri B. Dosoky N. Shari K. Al-Fahad A. Wessjohann L. Setzer W. Antimicrobial, antioxidant, and cytotoxic activities of ocimum forskolei and teucrium yemense (Lamiaceae) essential oils. Medicines (Basel) 2017 4 2 17 10.3390/medicines4020017 28930232
    [Google Scholar]
  29. Sghaier M.B. Boubaker J. Neffati A. Limem I. Skandrani I. Bhouri W. Bouhlel I. Kilani S. Chekir-Ghedira L. Ghedira K. Antimutagenic and antioxidant potentials of Teucrium ramosissimum essential oil. Chem. Biodivers. 2010 7 7 1754 1763 10.1002/cbdv.200900237 20658663
    [Google Scholar]
  30. Giamperi L. Bucchini A. Fraternale D. Cara P. Ricci D. Epifano F. Genovese S. Curini M. Chemical composition and antioxidant activity of the essential oil of Teucrium massiliense L. J. Essent. Oil Res. 2008 20 5 446 449 10.1080/10412905.2008.9700055
    [Google Scholar]
  31. Hammami S. Jmii H. Mokni R. Khmiri A. Faidi K. Dhaouadi H. Aouni M. Aouni M. Joshi R. Essential oil composition, antioxidant, cytotoxic and antiviral activities of teucrium pseudochamaepitys growing spontaneously in Tunisia. Molecules 2015 20 11 20426 20433 10.3390/molecules201119707 26580590
    [Google Scholar]
  32. Jaradat N. Al-lahham S. Abualhasan M.N. Bakri A. Zaide H. Hammad J. Chemical constituents, antioxidant, cyclooxygenase inhibitor, and cytotoxic activities of Teucrium pruinosum Boiss. essential oil. BioMed Res. Int. 2018 2018 4034689
    [Google Scholar]
  33. Hisham A. Pathare N. Al-Saidi S. Al-Salmi A. The composition and antimicrobial activity of leaf essential oil of Teucrium mascatenses Boiss. from Oman. J. Essent. Oil Res. 2006 18 4 465 468 10.1080/10412905.2006.9699142
    [Google Scholar]
  34. Ersoy E. Süvari G. Ercan S. Eroğlu Özkan E. Karahan S. Aygün Tuncay E. Yeşil Cantürk Y. Mataracı Kara E. Zengin G. Boğa M. Towards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approach. J. Ethnopharmacol. 2023 312 116482 10.1016/j.jep.2023.116482 37059244
    [Google Scholar]
  35. Vujanović M. Zengin G. Đurović S. Mašković P. Cvetanović A. Radojković M. Biological activity of extracts of traditional wild medicinal plants from the Balkan Peninsula. S. Afr. J. Bot. 2019 120 213 218 10.1016/j.sajb.2018.06.012
    [Google Scholar]
  36. Sabzeghabaie A. Asgarpanah J. Essential oil composition of Teucrium polium L. fruits. J. Essent. Oil Res. 2016 28 1 77 80 10.1080/10412905.2015.1082947
    [Google Scholar]
  37. Candela R.G. Rosselli S. Bruno M. Fontana G. A review of the phytochemistry, traditional uses and biological activities of the essential oils of genus Teucrium. Planta Med. 2021 87 6 432 479 10.1055/a‑1293‑5768 33296939
    [Google Scholar]
  38. Hasani-Ran S. Nayebi N. Larijani B. Abdollahi M. A systematic review of the efficacy and safety of teucrium species; From anti-oxidant to anti-diabetic effects. Int. J. Pharmacol. 2010 6 4 315 325 10.3923/ijp.2010.315.325
    [Google Scholar]
  39. Bruno M. Piozzi F. Maggio A.M. Rosselli S. Simmonds M.S.J. Servettaz O. Antifeedant activity of neo-clerodanediterpenoids from Teucrium arduini. 2002
    [Google Scholar]
  40. Abbaszadeh G. Srivastava C. Walia S. Insect growth inhibitory activity of clerodane diterpenoids isolated from clerodendron infortunatum L. on the Cotton Bollworm, Helicoverpa armigera (Hubner). Natl. Acad. Sci. Lett. 2012 35 5 457 464 10.1007/s40009‑012‑0077‑z
    [Google Scholar]
  41. Rodríguez B. de la Torre M.C. Bruno M. Piozzi F. Vassallo N. Ciriminna R. Servettaz O. Neo-clerodane diterpenoids from three species of Teucrium. Phytochemistry 1996 43 2 435 438 10.1016/0031‑9422(96)00319‑6
    [Google Scholar]
  42. Aydoğan F. Ali Z. Zulfiqar F. Karaalp C. Khan I.A. Bedir E. neo-Clerodanes from Teucrium divaricatum subsp. Divaricatum and their biological activity assessment. Phytochem. Lett. 2023 54 45 49 10.1016/j.phytol.2023.01.010
    [Google Scholar]
  43. Panicker N.G. Balhamar S.O.M.S. Akhlaq S. Qureshi M.M. Rizvi T.S. Al-Harrasi A. Hussain J. Mustafa F. Identification and characterization of the caspase-mediated apoptotic activity of Teucrium mascatense and an isolated compound in human cancer cells. Molecules 2019 24 5 977 10.3390/molecules24050977 30861999
    [Google Scholar]
  44. Cabral C. Francisco V. Cruz M. Lopes M. Salgueiro L. Sales F. Batista M. Potential antioxidant and anti-inflammatory properties in Teucrium salviastrum Schreb. Planta Med. 2010 76 12 s-0030 s-1264535 10.1055/s‑0030‑1264535
    [Google Scholar]
  45. Shah S.M.M. Shah S.M.H. Phytochemicals, antioxidant, antinociceptive and anti-inflammatory potential of the aqueous extract of Teucrium stocksianum bioss. BMC Complement. Altern. Med. 2015 15 1 351 10.1186/s12906‑015‑0872‑4 26446445
    [Google Scholar]
  46. El-Shazly A.M. Hussein K.T. Chemical analysis and biological activities of the essential oil of Teucrium leucocladum Boiss. (Lamiaceae). Biochem. Syst. Ecol. 2004 32 7 665 674 10.1016/j.bse.2003.12.009
    [Google Scholar]
  47. Micheli L. Nencini C. Galluzzi P. Pippi F. Menchiari A. Hepatotoxicity of Teucrium chamaedrys L. decoction: Role of difference in the harvesting area and preparation method. Indian J. Pharmacol. 2014 46 2 181 184 10.4103/0253‑7613.129313 24741190
    [Google Scholar]
  48. Loeper J. Descatoire V. Letteron P. Moulis C. Degott C. Dansette P. Fau D. Pessayre D. Hepatotoxicity of germander in mice. Gastroenterology 1994 106 2 464 472 10.1016/0016‑5085(94)90606‑8 8299912
    [Google Scholar]
  49. Fiorentino A. D’Abrosca B. Pacifico S. Scognamiglio M. D’Angelo G. Gallicchio M. Structure elucidation and hepatotoxicity evaluation against HepG2 human cells of neo-clerodane diterpenes from Teucrium polium L. J. Phytochemistry 2011 72 16 2037 2044
    [Google Scholar]
  50. Li H.Y. Wei W.J. Ma K.L. Zhang J.Y. Li Y. Gao K. Phytotoxic neo-clerodane diterpenoids from the aerial parts of Scutellaria barbata. Phytochemistry 2020 171 112230 10.1016/j.phytochem.2019.112230 31923722
    [Google Scholar]
  51. Bisio A. Damonte G. Fraternale D. Giacomelli E. Salis A. Romussi G. Cafaggi S. Ricci D. De Tommasi N. Phytotoxic clerodane diterpenes from Salvia miniata Fernald (Lamiaceae). Phytochemistry 2011 72 2-3 265 275 10.1016/j.phytochem.2010.11.011 21130478
    [Google Scholar]
  52. Stanković M. Stefanović O. Čomić L. Topuzović M. Radojević I. Solujić S. Antimicrobial activity, total phenolic content and flavonoid concentrations of Teucrium species. Open Life Sci. 2012 7 4 664 671 10.2478/s11535‑012‑0048‑x
    [Google Scholar]
  53. Djabou N. Lorenzi V. Guinoiseau E. Andreani S. Giuliani M.C. Desjobert J.M. Bolla J-M. Costa J. Berti L. Luciani A. Muselli A. Phytochemical composition of Corsican Teucrium essential oils and antibacterial activity against foodborne or toxi-infectious pathogens. Food Control 2013 30 1 354 363 10.1016/j.foodcont.2012.06.025
    [Google Scholar]
  54. Albayrak S. Aksoy A. Comparative analysis of phenolic compositions and biological activities of three endemic Teucrium L. (Lamiaceae) species from Turkey. An. Acad. Bras. Cienc. 2023 95 1 e20220184 10.1590/0001‑3765202320220184 37162086
    [Google Scholar]
  55. Bosisio E. Giavarini F. Dell’Agli M. Galli G. Galli C.L. Analysis by high-performance liquid chromatography of teucrin A in beverages flavoured with an extract of Teucrium chamaedrys L. Food Addit. Contam. 2004 21 5 407 414 10.1080/02652030410001670157 15204541
    [Google Scholar]
  56. Seremet D. Vojvodic Cebin A. Mandura A. Komes D. Valorisation of Teucrium montanum as a source of valuable natural compounds: Bioactive content, antimicrobial and biological activity – A review. Pharmacogn. Rev. 2021 15 30 191 198 10.5530/phrev.2021.15.18
    [Google Scholar]
  57. Asadi-Samani M. Rafieian-Kopaei M. Lorigooini Z. Shirzad H. A screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines. Biomedicine (Taipei) 2018 8 2 8 10.1051/bmdcn/2018080208 29806586
    [Google Scholar]
  58. Stanković M.S. Mitrović T.L. Matić I.Z. Topuzović M.D. Stamenković S.M. New values of Teucrium species: In vitro study of cytotoxic activities of secondary metabolites. Not. Bot. Horti Agrobot. Cluj-Napoca 2015 43 1 41 46 10.15835/nbha4319746
    [Google Scholar]
  59. Korkotadze T. Mshvildadze V. Jokhadze M. Gokadze S. Gviniashvili T. Maisashvili M. Chemical composition and biological activity of aerial parts of Teucrium polium l. Growing in Georgia. J. Exp. Clin. Med. 2023 ••• 4
    [Google Scholar]
  60. Korkotadze T. Berashvili D. Gokadze S. Jokhadze M. Getia M. Mchedlidze K. Legault J. Mshvildadze V. Chemical composition and biological activity of aerial parts of Thymus collinus Bieb. 2023
    [Google Scholar]
  61. Getia M. Korkotadze T. Moshiashvili G. Tabatadze N. Legault J. Mshvildadze V. Composition and cytotoxicity of essential oils from aerial parts of Thymus tiflisiensis and T. collinus Growing in Georgia. Chem. Nat. Compd. 2022 58 5 959 961 10.1007/s10600‑022‑03840‑5
    [Google Scholar]
  62. Singleton V.L. Rossi J.A. Jr Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic. 1965 16 3 144 158 10.5344/ajev.1965.16.3.144
    [Google Scholar]
  63. Legault J. Girard-Lalancette K. Dufour D. Pichette A. Antioxidant potential of bark extracts from boreal forest conifers. Antioxidants 2013 2 3 77 89 10.3390/antiox2030077 26784337
    [Google Scholar]
  64. Gauthier C. Lavoie S. Kubicki S. Piochon M. Cloutier M. Dagenais-Roy M. Structural characterization of a nonionic rhamnolipid from Burkholderia lata. Carbohydr. Res. 2024 535 108991
    [Google Scholar]
  65. Ou B. Hampsch-Woodill M. Prior R.L. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J. Agric. Food Chem. 2001 49 10 4619 4626 10.1021/jf010586o 11599998
    [Google Scholar]
  66. Mamelona J. Pelletier É. Girard-Lalancette K. Legault J. Karboune S. Kermasha S. Quantification of phenolic contents and antioxidant capacity of Atlantic sea cucumber, Cucumaria frondosa. Food Chem. 2007 104 3 1040 1047 10.1016/j.foodchem.2007.01.016
    [Google Scholar]
  67. Grenier A. Legault J. Pichette A. Jean L. Bélanger A. Pouliot R. Antioxidant, anti-inflammatory, and anti-aging potential of a Kalmia angustifolia extract and identification of some major compounds. Antioxidants 2021 10 9 1373 10.3390/antiox10091373 34573004
    [Google Scholar]
  68. Dufour D. Pichette A. Mshvildadze V. Bradette-Hébert M.E. Lavoie S. Longtin A. Laprise C. Legault J. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J. Ethnopharmacol. 2007 111 1 22 28 10.1016/j.jep.2006.10.021 17156957
    [Google Scholar]
  69. Legault J. Girard-Lalancette K. Grenon C. Dussault C. Pichette A. Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum. J. Med. Food 2010 13 2 460 468 10.1089/jmf.2009.0029 20132041
    [Google Scholar]
  70. Georgi Y. New furanoid diterpenes from Teucrium scordium L. Zeitsch. Naturforsch. B 1981 36 1 112 113
    [Google Scholar]
  71. Bedir E. Manyam R. Khan I.A. Neo-clerodane diterpenoids and phenylethanoid glycosides from Teucrium chamaedrys L. J. Phytochemistry 2003 63 8 977 983
    [Google Scholar]
  72. Antognoni F. Iannello C. Mandrone M. Scognamiglio M. Fiorentino A. Giovannini P.P. Poli F. Elicited Teucrium chamaedrys cell cultures produce high amounts of teucrioside, but not the hepatotoxic neo-clerodane diterpenoids. Phytochemistry 2012 81 50 59 10.1016/j.phytochem.2012.05.027 22769437
    [Google Scholar]
  73. Sundaresan P.R. Slavoff S.A. Grundel E. White K.D. Mazzola E. Koblenz D. Rader J.I. Isolation and characterisation of selected germander diterpenoids from authenticated Teucrium chamaedrys and T. canadense by HPLC, HPLC‐MS and NMR. Phytochem. Anal. 2006 17 4 243 250 10.1002/pca.912 16910040
    [Google Scholar]
  74. Wu L. Georgiev M.I. Cao H. Nahar L. El-Seedi H.R. Sarker S.D. Xiao J. Lu B. Therapeutic potential of phenylethanoid glycosides: A systematic review. Med. Res. Rev. 2020 40 6 2605 2649 10.1002/med.21717 32779240
    [Google Scholar]
  75. Fu G. Pang H. Wong Y. Naturally occurring phenylethanoid glycosides: Potential leads for new therapeutics. Curr. Med. Chem. 2008 15 25 2592 2613 10.2174/092986708785908996 18855681
    [Google Scholar]
  76. Kaplan Ö. Gökşen N. Biosynthesis of silver nanoparticles from Teucrioside and investigation of its antibacterial activity. Cumhuriyet Sci. J. 2021 42 1 60 67 10.17776/csj.809306
    [Google Scholar]
  77. Erden Tayhan S. Bi̇lgi̇n S. Elmastaş M. Evaluation of the wound healing potential of Teucrioside. Int. J. Chem. Technol. 2018 2 1 16 19 10.32571/ijct.345050
    [Google Scholar]
  78. Li R. Morris-Natschke S.L. Lee K.H. Clerodane diterpenes: Sources, structures, and biological activities. Nat. Prod. Rep. 2016 33 10 1166 1226 10.1039/C5NP00137D 27433555
    [Google Scholar]
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Phytochemical Characterization of the Aerial Parts of Teucrium nuchense K. Koch: An Endemic Species of Caucasian Flora
Bentham Science Publishers ; https://doi.org/10.2174/0122103155317820240827071846
/content/journals/npj/10.2174/0122103155317820240827071846
/content/journals/npj/10.2174/0122103155317820240827071846
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  • Article Type:     Research Article
Keywords: Teucrium nuchense ; phenolic compounds ; Labiatae (Lamiaceae) ; essential oil ; biological activity

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