- Home
- A-Z Publications
- Natural Products Journal, The
- Fast Track Listing
Natural Products Journal, The - Online First
Description text for Online First listing goes here...
-
-
Bio-prospecting the Anti-oxidative and Radioprotective Role of Bioactive Pigment Isolated from Pontibacter indicus
Available online: 21 October 2024More LessAimTo evaluate the anti-oxidative and radioprotective role of Pontibacter indicus SCG24 pigment during radiation exposure
BackgroundRadiation-induced cytotoxicity is quite common during cancer therapy. There is a need for naturally derived therapeutic molecules that can scavenge free radicals. They may act as substitutes for synthetic molecules. Hence, there is a need for urgent evaluation of these potent compounds before therapeutic application.
ObjectiveThe objective of this study is to examine the anti-oxidative and radioprotective role ofP. indicus SCG24 pigment, specifically to evaluate free radical scavenging X-ray irradiated HDF cells
MethodA radiotoleraent pigment-producing P. indicus SCG24 was isolated from pharmaceutical effluent. Chloroform was used as a primary solvent for pigment extraction. GCMS/MS analysed initial pigment composition. Various In-vitro antioxidant assays were performed using ABTS, FRAP, and DPPH assay. Flow cytometry was used to determine the rate of scavenging activity of pigment in HDF cells.
ResultsThe GCMS/MS profile of the chloroform extract revealed twenty-two compounds. Furthermore, based on the DPPH, ABTS, and FRAP assay, the pigment was found to have significant antioxidant properties. The flow cytometry results indicate that the pigment possesses radioprotectant activity by neutralizing ROS species in HDF cells when exposed to X-ray radiation.
ConclusionThese observations on P. indicus SCG24 pigment suggested that the pigment may have potential therapeutic importance.
-
-
-
Polyene Macrolactams from Marine Micromonospora sp.
Authors: Wei Zhao, Jian Zhou, Fei Sun, Honglei Jiang, Ru Lin, Jingming Zhou, Xiuming Chen, Usman-Dawood Butt, Yi-nuo Wang, Hong Jiang and Bin WuAvailable online: 11 October 2024More LessIntroductionThree novel macrolactams, FW8-1 (1), FW8-4 (2), and FW60-20 (3), were isolated from a culture of Micromonospora sp. The structures of these compounds were elucidated using Mass Spectrometry (MS) and comprehensive Nuclear Magnetic Resonance (NMR) analyses.
MethodsThe relative configurations of compounds 1-3 were assigned through theoretical calculations of their NMR spectra.
ResultsThe isolation and determination of the relative configurations of these macrolactams have provided fresh perspectives on the biosynthetic pathways, leading to the formation of polyene macrolactams.
ConclusionFurther, virtual screening and bioactivity predictions have suggested compounds 1-3 to possess potential anti-tumor, anti-inflammatory, and neuroprotective properties.
-
-
-
Antimicrobial Macrolide Levantilide D from Rare Marine Micromonospora sp.
Authors: Wei Zhao, Jian Zhou, Honglei Jiang, Yichao Ge, Jingming Zhou, Meilu Zhao, Ru Lin, Hong Jiang and Bin WuAvailable online: 10 October 2024More LessIntroductionOne new levantilide D (2) with a 20-membered macrolide, along with one known levantilide C (1), was isolated from a rare marine actinomycetes Micromonospora sp. (FIMYZ52).
MethodThe structural elucidation of the compounds was based on integrated analyses involving 1D and 2D NMR spectroscopy and HR-ESI-MS.
ResultThe relative and absolute configurations of compounds 1 and 2 were ascertained by integrating multispectral ROESY and NOESY information from analogs in conjunction with theoretical TDDFT-ECD calculations. Levantilide D (2) exhibited antibacterial activity against Staphylococcus aureus.
ConclusionA plausible biosynthetic pathway of the macrolide compounds (1-2) was proposed.
-
-
-
Milestones in the Technology of Modified Starch in Pharmaceutical Formulation
Available online: 09 October 2024More LessCarbohydrates, the most prevalent class of organic substances in living systems, play a variety of important roles, such as in the creation of energy, the construction of biological structures, and the synthesis of paper and food. More advanced uses of modified starch have been introduced over the past millennium, demonstrating that modified starches are promising excipients in drug delivery, an area in which their role and range of utility continuously increase. Technological advancements in the pharmaceutical field have led to the development of new and highly stable molecules with enhanced properties for novel drug delivery systems. Innovative starches from various sources present exclusive support in the development of novel dosage forms.
-
-
-
Unveiling the Underlying Mechanisms Related to the Biological Activities of Cynometra cauliflora
Authors: Siti Rosmani Md Zin, Noor Eliza Hashim, Srijit Das and Intan Suhana ZulkafliAvailable online: 09 October 2024More LessCynometra cauliflora Linn. (C. cauliflora), a member of the Fabaceae family within the Cynometra genus, is an underrated medicinal plant in Malaysia. It features frog-like fruits and is known locally as Namnam. The plant grows in tropical regions and is used in the traditional treatment of various medical conditions. Previous studies have revealed a broad range of its pharmacological benefits, including antioxidant, anti-inflammatory, anti-diabetic, anti-lipase, anti-diarrheal, cytotoxic, anti-microbial, and anti-cholinesterase properties. The active constituents identified in C. cauliflora are thought to contribute to its diverse range of biological activities. Research shows that different parts of C. cauliflora contain phenolic compounds, tannins, saponins, and flavonoids. The leaves and bark also have cardiac glycosides, while the fruit is rich in flavonoids, triterpenoids, saponins, and tannins. Furthermore, ethanol extracts of its leaves were found to contain vitamin C and its major constituent, vitexin. In this review, the biological activities of C. cauliflora are explored and reviewed through various literature sources, aiming to highlight the mechanisms and compounds that underlie its potential as a source for natural therapies.
-
-
-
Phytochemical Characterization of the Aerial Parts of Teucrium nuchense K. Koch: An Endemic Species of Caucasian Flora
Available online: 05 September 2024More LessBackgroundThe genus Teucrium L. is frequently employed in traditional medicine, primarily for addressing disorders of the digestive and respiratory systems. Biological investigations focused on essential oils have substantiated their antibacterial, antioxidant, anti-tumor, anti-diabetic, and anti-rheumatic properties.
ObjectiveThe aim of the study was to assess the chemical composition and biological activities of the aerial parts of the endemic species Teucrium nuchense K. Koch.
MethodsThe chemical composition of the essential oil was analyzed using gas chromatography-mass spectrometry (GC-MS). The antioxidant activity was evaluated through the Oxygen Radical Absorbance Capacity (ORAC) assay and tested on normal skin fibroblasts (WS-1). Additionally, the anti-inflammatory efficacy was assessed by monitoring nitric oxide production. The total phenolic content in the aqueous, methanolic, and chloroformic extracts was quantified using the Folin-Ciocalteu reagent. Individual compounds were isolated using preparative high-performance liquid chromatography. Their identification was accomplished using high-resolution mass spectrometry (HRMS) with an ESI-Q-TOF detector in conjunction with nuclear magnetic resonance (NMR) spectroscopy.
ResultsThe essential oil yield was 0.32 ml/kg. Caryophyllene oxide, constituting 15.19%, and 1-octen-3-ol, constituting 8.75%, emerged as the primary components in the essential oil. Oxygenated sesquiterpenes dominated the terpenic compounds, representing 25.1% of the essential oil. The aqueous and methanolic extracts displayed a notable phenolic content, with percentages of 27 ± 2% and 35 ± 0.1%, respectively. Both the aqueous and methanolic extracts demonstrated robust antioxidant activity in the ORAC test and in vitro assessments using WS-1 cells. The methanolic extract, at a concentration of 160 μg/ml, inhibited NO formation by 90%, without toxicity in RAW 264.7. Individual compounds, teucrioside from the phenylethanoid glycoside class, two neo-clerodane diterpenes, teucrin A, and 6-alpha-hydroxyteuscordine, were isolated.
ConclusionThe essential oil extracted from the aerial parts of Teucrium nuchense is characterized by the presence of caryophyllene oxide and 1-octen-3-ol. The methanolic extract exhibits notable antioxidant as well as anti-inflammatory properties, whereas the aqueous extract demonstrates high antioxidant activity. Additionally, three compounds of teucrioside, teucrin A, and 6-α-hydroxyteuscordine have been isolated and characterized.
-