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image of Isolation and Structural Determination of Cyclic Dipeptides Produced by Arthrobacter sp.

Abstract

Introduction

is a genus of bacteria that has gained recent attention due to its unique ability to produce bioactive compounds that possess potential antimicrobial properties.

Method

In this study, we isolated two cyclic dipeptides (CDPs) from sp. obtained from a soil sample.

Result

The isolated sp. exhibited inhibitory activity against a filamentous indicator bacterium and a violacein-producing sp. Cultivation of sp. TAJX1902 was carried out using rich medium broth and agar to facilitate the extraction of metabolites. The isolated compounds were characterized through spectroscopic techniques. GCMS analysis of the crude extract revealed the presence of bioactive cyclic dipeptides.

Conclusion

The structures of the isolated CDPs were determined as acylated cyclo(D-phenylalanine-4-hydroxy-D-proline) () and cyclo(D-phenylalanine-D-proline) (). Furthermore, two additional metabolites, 2,4-dihydroxypyrimidine () and 2,4-dihydroxy-5-methylpyrimidine (), were identified and verified through NMR spectral analysis.

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2025-01-07
2025-07-03

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Isolation and Structural Determination of Cyclic Dipeptides Produced by Arthrobacter sp.
Bentham Science Publishers ; https://doi.org/10.2174/0122103155345478241106061631
/content/journals/npj/10.2174/0122103155345478241106061631
/content/journals/npj/10.2174/0122103155345478241106061631
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  • Article Type:     Research Article
Keywords: Arthrobacter ; soil bacteria ; Cyclic dipeptides ; bioactivity ; metabolites

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