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Antifungal Resistance in Vaginal Candidiasis Among Reproductive-age Women: A Review
Available online: 08 May 2025More LessCandida is a type of fungus that can cause infections in humans. Sometimes, these infections become tough to treat because the Candida fungus resists antifungal drugs. This resistance depends on both the specific type of Candida and how it interacts with the human body. For instance, Candida can change its genetic makeup or produce proteins that pump out the drugs, making them less effective. Additionally, Candida Read More
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Optimization and Characterization of Khellin Loaded Nanogels for the Potential Use in Psoriasis Management
Available online: 05 May 2025More LessBackground Psoriasis is a chronic skin disease that affects patients' quality of life. Treating psoriasis remains a significant challenge due to various factors, including individual response variability, drug resistance, and the range of side effects associated with currently available medications. Nowadays, numerous research efforts are being made aiming at overcoming the obstacles of the available psoriasis treatments are still Read More
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The Biological Effects of Nano-curcumins against Drugs and Chemicals-Induced Nephrotoxicity: A Systematic Review
Available online: 30 April 2025More LessIntroduction/Objective Drug and chemical nephrotoxicity is a common cause of kidney disorders. This systematic review aimed to evaluate the recent progress in applying nano-curcumins (nano-CURs) to prevent and mitigate drug and chemical-induced nephrotoxicity, highlighting their underlying protective mechanisms and therapeutic potential. Methods A comprehensive search of experimental and clinical studies was Read More
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Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology
Authors: Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li and Yi QinAvailable online: 29 April 2025More LessObjective To predict and assist in the treatment of colorectal cancer. Background Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions. Aim To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation. Methods The system includes the use of cel Read More
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Sirtuins in Osteosarcoma: Cracking the Code and Opening Up New Treatment Options
Authors: Yushi Zhao, Yong Han, Baichuan Wang and Ting WangAvailable online: 25 April 2025More LessOsteosarcoma (OS) is a frequent primary malignant bone tumor that primarily affects adolescents and the elderly, and it is prone to metastasis and recurrence. The prognostic status of metastatic and recurrent OS has remained stagnant over the past decades despite the availability of an extensive range of chemotherapy drugs in the clinic. To increase the overall survival and quality of life of patients with osteosarcoma, ne Read More
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A Baicalin-targeted ZHX2/MMP14 Axis Attenuates Cirrhotic Portal
Authors: Hui Wang, Jiawei Ma, Jinghe Liu, Xiao Liu, Xiao Cai and Yufei ChangAvailable online: 24 April 2025More LessBackground Given the high mortality associated with Cirrhotic Portal Hypertension (CPH) worldwide, this study investigates the mechanism by which baicalin (BA), known for its beneficial effects on cirrhosis, alleviates CPH. Methods The CPH model was established in Sprague-Dawley (SD) rats, followed by 4-week oral administration of 30 and 60 mg/kg/day BA. SD rats were randomly assigned to four groups (n=6/group): Con, M Read More
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Anti-Cancer Properties and Mechanistic Insights of Dihydroquercetin
Authors: Cheng Zhang, Yuqiao Zeng, Bing Wu, Li Wang, Pengfei Wu, Ao Shen and Likun WangAvailable online: 24 April 2025More LessDihydroquercetin (DHQ), also known as taxifolin, is a naturally occurring flavonoid compound that serves as an active pharmaceutical ingredient. It is commercially available in the form of dietary supplements. As the reduced form of quercetin, DHQ contains five phenolic hydroxyl groups. This compound is capable of chelating transition metal ions, thereby effectively scavenging free radicals and detoxifying harmful substances Read More
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Selenium Alleviates Oxidative Stress and Inflammation to Promote Postpartum Uterine Recovery via GPX1/GPX4/NRF2 Pathway in Mice
Authors: Xiangping Li, Peng Li and Pingzhi WangAvailable online: 24 April 2025More LessBackground Selenium is an important trace element that plays crucial roles in metabolism, immune function, and antioxidant defense. As an antioxidant, selenium helps to alleviate postpartum uterine inflammation and promotes uterine recovery. However, the exact mechanism underlying the role of selenium in postpartum uterine recovery is not fully understood. Objective This study aimed to identify the underly Read More
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Challenges and Pathways in Regulating Next-Gen Biological Therapies
Authors: Surendra Agrawal, Sunita Vaidya, Jitendra Patel, Pranita Jirvankar and Pravina GurjarAvailable online: 23 April 2025More LessBackground Current medicine could benefit from gene and cell therapies for genetic defects, cancer, and degenerative disorders. These therapies modify genetic material or biological components. CRISPR-Cas9 gene editing, stem cell, and CAR-T treatments are examples. Complex products need rigorous regulations to ensure quality, efficacy, and patient safety. Objectives This paper discusses international gene and cell-base Read More
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A Comprehensive 4-Layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-Addiction Assessment Tool in the Opioid Crisis Era
Authors: Alireza Sharafshah, Kai-Uwe Lewandrowski, Igor Elman, David Baron, Panayotis K. Thanos, Colin Hanna, Mark S. Gold, Rajendra D. Badgaiyan, Jean Lud Cadet, Edward J. Modestino, Eric R. Braverman, Catherine A. Dennen, Milan Makale, Keerthy Sunder, Kevin T. Murphy, Abdalla Bowirrat, Albert Pinhasov, Marjorie Gondre-Lewis, Eliot Gardner, Daniel Sipple, Nicole Jafari, Foojan Zeine, Jag Khalsa, Rossano Kepler, Alvim Fiorelli and Kenneth BlumAvailable online: 16 April 2025More LessBackground Overdose involving opioids is the black heart of the addiction crisis. “Pre-addiction,” as an encouraging concept by NIDA and NIAAA, seems best captured with the construct of dopamine dysregulation. Referring to the abundant publications on “Reward Deficiency Syndrome” (RDS), Genetic Addiction Risk Score (GARS) test, RDSQ29, and KB220, Pre-addiction can be referred to as “reward dysregulation” as a su Read More
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Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review
Available online: 15 April 2025More LessTuberculosis (TB) continues to be a major global health challenge largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs focusing Read More
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Molecular Mechanisms of Immune Resistance in Pancreatic Cancer: An Update
Authors: Wei Ming Pang, Wei Meng Lim, Zi Ni Ngai and Rhun Yian KohAvailable online: 15 April 2025More LessPancreatic cancer is an exceptionally aggressive form of cancer with a poor prognosis, primarily due to several factors, one of which is the significant development of immune resistance. Despite new medical perceptions of the interaction between the immune system and tumour, experts have continually explored the molecular mechanisms of immune resistance in pancreatic cancer over the years but have not ye Read More
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Interaction Between Staphylococcus aureus and Microbiota: Invasion or Commensalism
Authors: Ahmad Nasser and Shiva JahanbakhshiAvailable online: 14 April 2025More LessThe term “Microbiota” refers to the vast array of symbiotic microorganisms that coexist with their hosts in practically all organs. However, the microbiota must obtain nutrition and minerals from its host to survive; instead, they produce beneficial compounds to protect the host and regulate the immune system. Conversely, pathogenic bacteria utilize their enzymes to independently gain sustenance through an invasive proces Read More
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Protective Role of Coffee in Thioacetamide-induced Nephrotoxicity: A Study in Rats
Available online: 09 April 2025More LessObjectiveThe purpose of the present research was to assess the protective role of coffee in thioacetamide-induced nephrotoxicity.MethodsThe experimental period consisted of 18 weeks, divided into two phases. Four experimental groups were designed, each consisting of six rats. Group I was considered an untreated control group. Groups II and III were intraperitoneally injected with thioacetamide at a dose of 200 mg/kg Read More
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Bioactive Phytochemicals: Unlocking the Promise of Natural Remedies for Diabetes Mellitus
Authors: Diksha Gulati, Ajmer Singh Grewal and Balraj SainiAvailable online: 03 April 2025More LessBackground Metabolic syndrome encompasses conditions such as diabetes mellitus (DM), which has become increasingly prevalent. Chemically synthesized medications are commonly used to mitigate the effects of DM and its complications; however, these often result in undesirable side effects, including weight gain, digestive issues, and heart failure. Objective This review highlights the therapeutic potential of bioactive c Read More
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Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation
Authors: Zhixin Wang, Shuqin Liu, Ying Zhang, Huaming Xian, Xinzhu Yuan, Changwei Lin and Xisheng XieAvailable online: 27 March 2025More LessBackground Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear. Objective This study tests the hypothesis that Read More
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Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now
Authors: Zhenghao Chen, Zhongqing Wang and He MaAvailable online: 19 March 2025More LessBackground Bibliometrics has been applied to the study of tumor image segmentation, which can indicate the current research hotspots and trends. Methods In this study, bibliometric analyses were performed on data retrieved from the Web of Science database. A total of 3,377 articles on the application of tumor image segmentation from January 1, 2003, to October 9, 2024, were analyzed for the characteristics of the Read More
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Recent Advancements in Nanoparticles-based Approaches for the Theranostics of Glioblastoma Multiforme
Authors: Jugal Mandan and Abhishek KanugoAvailable online: 18 March 2025More LessOne of the deadliest and most challenging tumors in the body is Glioblastoma Multiforme (GBM). The Most aggressive kinds of brain tumors pose multiple challenges in their treatment due to several barriers (BBB and BCSF). Conventional treatments show poor efficacy in the treatment owing to poor penetrability through the blood-brain barrier and extreme toxicity in the brain. Moreover, the prognosis and diagnosis of GBM ar Read More
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Construction and Validation of T‐cell Exhaustion‐related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma
Authors: Lixin Lv, Jie Zhou and Aibin LiangAvailable online: 18 March 2025More LessBackground T-cell exhaustion (TEX) is one reason for immunotherapy resistance among cancers, but the specific mechanism and influencing factors of TEX in diffuse large B-cell lymphoma (DLBCL) are not fully understood. This study aimed to establish a TEX signature for predicting the prognosis of DLBCL and investigate the immune characteristics related to the TEX signature. Methods The gene expression data of DLB Read More
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Progress and Application of Multifunctional Ultrasound Theranostic Agents
Authors: Kejing Fang, Jincan Lei, Yi Zhao, Yujie Feng, Haiyun Huang and Changjun HouAvailable online: 07 March 2025More LessUltrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctio Read More
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In-vitro, In-vivo and Molecular Docking Studies on Dietary Supplement Containing Polar and Non-polar fractions of Persea Americana for Management of Diet-related Chronic Diseases
Authors: Doha A. Mohamed, Gamil Ibrahim, Hoda B. Mabrok and Ibrahim HamedAvailable online: 05 March 2025More LessBackground Diet-related chronic diseases, such as cardiovascular diseases, obesity, diabetes, autoimmune diseases and cancer, are largely preventable with a healthy diet and lifestyle. Therefore, searching for dietary supplements rich in antioxidant and anti-inflammatory phytochemicals for the prevention and/or management of diet-related chronic diseases is an important strategy for controlling these dis Read More
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In vitro Antibiofilm Activity-directed In silico Identification of Natural Products Targeting Bacterial Biofilm Regulators SarA and LasR
Available online: 18 February 2025More LessBackground Antibiofilm agents serve as an essential tool in the fight against antibiotic resistance, and natural products provide a promising source for potential drug leads. Objective This study investigates the activity of twenty Bangladeshi medicinal plants against Staphylococcus aureus and Pseudomonas aeruginosa biofilms and predicts the interactions of selected phytochemicals from five of the best performing plants with Read More
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The Role of Immunosenescence and Inflammaging in the Susceptibility of Older Adults to SARS-CoV-2 Infection
Available online: 13 February 2025More LessCOVID-19 is an ongoing pandemic caused by the SARS-CoV-2 coronavirus that is one of the most significant challenges to public health over the past few years. Most people are vulnerable to SARS-CoV-2, but older adults are more vulnerable. Aging is one of the major risk factors for the detrimental consequences of COVID-19, likely due to chronic inflammation and immunosenescence, both of which are the characteristic Read More
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Research on Neuroimmune Gastrointestinal Diseases Based on Artificial Intelligence: Molecular Dynamics Analysis of Caffeine and DRD3 Protein
Authors: Yi Qin, Shuran Huo, Ana María González, Lizhong Guo, Javier Sanots and Liangyu LiAvailable online: 04 February 2025More LessObjective The aim of this study was to develop a clinical application model for the rational use of caffeine. Background Caffeine is related to the incidence of neuro immune gastrointestinal diseases. Coffee consumption needs to be optimized in order to reduce the incidence rate. Purpose By using KEEG analysis to explore potential molecular signaling pathways involved in the progression of neurological immune gastrointestin Read More
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HYQTD Drug-containing Serum Alleviates H2O2-induced Endothelial Oxidative Damage by Increasing Mitochondrial ATP Synthesis and Inhibiting ROS
Authors: Jin Wu, Lijuan Chen, Ying Du, Xue Leng, Dongchao Yuan, Mingqian Yang, Yeyu Zhao, Bin Lv and Lianqun JiaAvailable online: 27 January 2025More LessBackground Atherosclerosis (AS) is caused by the endothelium injury associated with oxidative stress. Previous studies have shown that the Phlegm-Eliminating and Stasis-Transforming Decoction (Huayu Qutan Decoction, HYQTD) has mitochondrial protective function. The objective of this research was to explore how HYQTD drug-containing serum (HYQTD-DS) could potentially protect mitochondrial energy production in en Read More
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Harmony in Motion: The Role of Exercise in Orchestrating Neuroprotection for Individuals with Alzheimer's Disease and Diabetes Examined from a Psychological Perspective
Authors: Dongzi Zhang, Munir Ullah Khan and Safir UllahAvailable online: 24 January 2025More LessAccording to epidemiological studies, diabetes is more common in patients with AD, which suggests that diabetes is a significant risk factor for AD. Accelerating brain cell degeneration, worsening cognitive decline, and increasing susceptibility to AD can be attributed to pathogenic mechanisms linked to diabetes, such as impaired insulin signaling in the brain, neuroinflammation, oxidative stress, mitochondrial dysfunction, and va Read More
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A Therapeutic Approach of Chitosan-loaded p-Coumaric Acid Nanoparticles to Alleviate Diabetic Nephropathy in Wister Rats
Available online: 23 January 2025More LessObjective This study evaluated the renoprotective effects of p-Coumaric acid nanoparticles (PCNPs) in nephropathic rats. Methods Six groups of male Albino Wistar rats were randomly assigned. Group 1 was the control, while Group 2 received 45 mg/kg of streptozotocin (STZ) to induce diabetic nephropathy. Groups 3, 4, and 5 received STZ (45 mg/kg) along with PCNPs at doses of 20, 40, and 80 mg/kg, respectively. Grou Read More
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A Fed-batch Process for the Production of Recombinant Adeno-Associated Virus (rAAV) Vectors Using the Sf9-Rhabdovirus-Negative Cell Line
Authors: Xinran Li, Jieyi Gu, Haoquan Wu and Yuanyuan XieAvailable online: 23 January 2025More LessBackground Gene therapy has been effectively applied in many biological studies and for the treatment of many genetic or cancer diseases. Currently Recombinant Adeno-Associated Viruses (rAAVs) are one of the main types of delivery vectors used for gene therapy. rAAV vectors produced via the Sf9 cells have the advantages of high rAAV yields easy scale-up and low cost. Method Here we used Sf9 rhabdovirus-n Read More
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Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment
Authors: Songhui Zhai, Juan Zhao and Jian CaiAvailable online: 22 January 2025More LessIntroduction Prostate cancer is an androgen-dependent malignancy, and the use of androgen deprivation therapies frequently results in treatment resistance, relapse, and the development of aggressive castration-resistant tumors. Patchouli alcohol, a tricyclic sesquiterpene derived from Pogostemon cablin of the Labiatae family, has demonstrated potential in modulating inflammatory responses and tumor progression. Th Read More
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Identifying Novel Therapeutic Opportunities for Dilated Cardiomyopathy: A Bioinformatics Approach to Drug Repositioning and Herbal Medicine Prediction
Authors: Jiao Wang, Tianwei Meng, Na Si, Haihong Li, Yan Yan and Xinghua LiAvailable online: 15 January 2025More LessBackground Dilated Cardiomyopathy (DCM) is a debilitating cardiovascular disorder that challenges current therapeutic strategies. The exploration of novel drug repositioning opportunities through gene expression analysis offers a promising avenue for discovering effective treatments. Objective This study aims to identify potential drug repositioning opportunities and lead compounds for DCM treatment by optimizing ge Read More
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COL1A1, COL1A2, CHN1, and FN1 Promote Tumorogenesis and Act as Markers of Diagnosis and Survival in Gastric Cancer Patients
Authors: Yan Yichao, Li Yongbai, Liang Hailiang, Chen Dongbo, Li Bo and Abduh MurshedAvailable online: 13 January 2025More LessObjectives This study aimed to comprehensively investigate the molecular landscape of gastric cancer (GC) by integrating various bioinformatics tools and experimental validations. Methodology GSE79973 dataset, limma package, STRING, UALCAN, GEPIA, OncoDB, cBioPortal, DAVID, TISIDB, Gene Set Cancer Analysis (GSCA), tissue samples, RT-qPCR, and cell proliferation assay were employed in this study. Results Analysis of t Read More
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Impact and Significance of Viral Vectors for siRNA Delivery in the Treatment of Alzheimer’s Disease
Authors: Chintan Aundhia, Ghanshyam Parmar, Chitrali Talele, Rahul Trivedi, Mamta Kumari and Jay ChudasamaAvailable online: 09 January 2025More LessAlzheimer’s disease (AD) remains a major challenge in developing effective treatments due to its complex pathophysiology, including the accumulation of amyloid-beta plaques and tau tangles. Small interfering RNA (siRNA) technology offers promise for targeted gene silencing, but effective delivery to the central nervous system remains a significant obstacle. Viral vectors have emerged as potent delivery vehicles f Read More
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Biomimetic Fe3O4 Nanozymes Promote Apoptosis in Breast Cancer Cell Lines via Free Radical Scavenging and Inhibition of RelA/p65
Authors: Deepa Mundekkad and William C. ChoAvailable online: 07 January 2025More LessIntroduction Iron oxide nanozyme was synthesized from the fruit peel extract of pomegranate, which served as a reducing agent during the green synthesis. The scavenging of reactive oxygen species is often accompanied by immunomodulation following antiproliferative effects due to the crosstalk between the proteins involved in the inter-related signaling pathways. Method In the current study, the green synthesized nano Read More
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The Exosome and its Application in Skin Wound Healing: A Systematic Review on In vitro Studies
Available online: 06 January 2025More LessBackground Wound healing is a complex procedure frequently delayed in patients with underlying chronic conditions. Despite essential advances in tissue engineering and regenerative medicine, wound healing remains challenging, warranting novel methods for promoting wound healing. It has been demonstrated that exosomes are one of the main secretory products of different cell types, such as Mesenchymal Stem Cells (MS Read More
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In vitro Investigation of Antimicrobial and Antioxidant Properties of Green Silver Nanoparticles Synthesized Using Ephedra gerardiana Plant Extract
Available online: 06 January 2025More LessBackground The increasing prevalence of antibiotic-resistant bacteria necessitates exploring nanotechnology as a potential solution for microbial elimination. Objectives This study aimed to investigate the antimicrobial and antioxidant effects of silver nanoparticles synthesized using aqueous extract from the Ephedra gerardiana (E. gerardiana) plant (EG@AgNPs). Methods Optimal synthesis conditions, including silver nitrate co Read More
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Strengthening Effect of Thalidomide Combined with an Anti-PD1 Antibody on Enhancing Immunity for Lung Cancer Therapy
Authors: Qing Liu, Zu-Chian Chiang, Xiangqian Zhao, Dongya Cui, Xinxin Li, Hao Chen, Fangyu Lin, Tao Jiang, Qi Chen, Xiaoyan Lin and Jizhen LinAvailable online: 03 January 2025More LessObjective Combining immune checkpoint inhibitors and antiangiogenic agents offers a promising strategy to counteract the cooperative promotion of solid tumor growth by immune checkpoints and intratumoral angiogenesis. Methods We investigated the potential of thalidomide (THD) and anti-PD-1 antibody (PD-1 mAb) in suppressing tumor growth, enhancing immunity, and inhibiting angiogenesis. Results THD exhibited regulat Read More
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CAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment
Authors: Dhitri Borah, Sibasree Hojaisa, Indira Sarma, Anil Kumar Mavi, Tejveer Singh, Anita Gulati, Ravi, Kumar Goswami and Saurabh MaruAvailable online: 01 January 2025More LessThe world's one of the major causes of death are cancer. Cancer is still a complex disease over the years that needs to be cured. Traditional cytotoxic approaches, although they have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy and low efficiency of cancer cells. Researchers are thus compelled to seek more potent therapeutic strategies. Chimeric antigen receptor (CAR-T Read More
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Effect of Ficus Carica and Zea Mays on Calcium Release from Oxalocalcic Urinary Calculi Using the Potentiometric Method
Available online: 30 December 2024More LessIntroduction A stone is a compact mass of one or more crystallised substances. The essential mechanism of stone formation is an excessive concentration of poorly soluble compounds in the urine. In excessive concentration, these compounds precipitate into crystals, which then aggregate to form a stone. The use of certain plants using the turbidimetric model has shown positive results on oxalocalcic crystallisati Read More
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Advances and Challenges of Microneedle Assisted Drug Delivery for Biomedicals Applications: A Review
Authors: Shiv Bahadur, Radhika, Kantrol Kumar Sahu and Arun Kumar SinghAvailable online: 04 November 2024More LessMicroneedles have been explored as a novel way of delivering active ingredients into the skin. They have various advantages, such as quick and efficient drug delivery, mechanical stability, minimal pain, variable capacity and easy use. Microneedles are enabled for the delivery of vaccine, peptides, medicinal components and in cosmetology, which couldn’t go unnoticed. The novel approaches in the transdermal drug delive Read More
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Influence of Nanomedicine as a Smart Weapon on Multidrug Resistance in Cancer Therapy
Authors: Safal Kumar Paikray, Liza Sahoo, Nigam Sekhar Tripathy and Fahima DilnawazAvailable online: 31 October 2024More LessCancer is the leading cause of death worldwide. The effectiveness of chemotherapy in cancer patients is still significantly hampered by Multidrug Resistance (MDR). Tumors exploit the MDR pathways to invade the host and limit the efficacy of chemotherapeutic drugs that are delivered as single drugs or combinations. Further, overexpression of ATP-binding Cassette transporter (ABC transporter) proteins augments the efflu Read More
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Considerations and Challenges to Develop Drug-drug Coamorphous System: A Recent Update
Authors: Madhura Tiwari, Kavita Singh and Bappaditya ChatterjeeAvailable online: 30 October 2024More LessPoor water solubility of several drugs, especially BCS class II and IV drugs, restricts their dissolution and negatively affects oral absorption. Amorphization of drugs is a year-old approach to enhance solubility and dissolution of poorly water-soluble drugs. Polymeric amorphous systems have been proven effective but have disadvantages, such as low drug loading, high carrier content, etc. In a coamorphous system, a sm Read More
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Virus-like Particles-Based Vaccine to Combat Neurodegenerative Diseases
Available online: 29 October 2024More LessNeurodegenerative diseases are regarded as gradual, incurable conditions with an insidious onset. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two of the most prevalent neurodegenerative diseases reported globally. Developing effective treatment strategies for neurodegenerative diseases has remained a primary objective and a huge challenge for researchers. The therapeutic medications that Read More
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Tryptophan Stability and Palatability in the Food Formulation: A Review
Available online: 29 October 2024More LessTryptophan, an essential amino acid, plays a vital role in the synthesis of critical compounds like serotonin, melatonin, and niacin, which impact mood, sleep, and metabolic processes. It holds promise for improving the well-being of individuals with mood issues or sleep disorders through dietary enrichment. However, incorporating tryptophan into food products presents challenges related to stability, bitterness, and susce Read More
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Mechanisms of Bioactive Lipids to Modulate Master Regulators of Lipid Homeostasis and Inflammation in Metabolic Syndrome
Available online: 25 October 2024More LessMetabolic Syndrome (MetS) refers to the co-occurrence of a constellation of metabolic diseases in the same individual, such as abdominal/visceral obesity, insulin resistance or diabetes, alterations in the lipid profile (dyslipidemias), and/or hypertension, which promotes the development of other cardiometabolic and hepatic diseases. Dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD), previously ter Read More
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SIRT3, a New Hope in Liver Diseases from Pathogenic Mechanisms to Therapeutic Strategies
Authors: Sai-Ya Tan, Xiao-Xuan Chen, Rui Zhang, Pan Liu, Jian-Peng Wang, Ting Wang, and and Zhang-E XiongAvailable online: 24 October 2024More LessThe liver, the largest internal organ in the human body, regulates multiple reactions and processes, including detoxification, regeneration, and immune defense. Liver diseases have emerged as a significant global public health issue. Numerous studies have indicated that the mitochondrial deacetylase SIRT3 has played various roles in the pathogenesis and pathological progression of liver diseases. Objectives This review ai Read More
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Revolutionizing Influenza Treatment: A Deep Dive into Targeted Drug Delivery Systems
Authors: Sourav Ghosh, Sejuti Ray Chowdhury, Monosiz Rahaman, Biswajit Basu and Bhupendra PrajapatiAvailable online: 21 October 2024More LessInfluenza, a highly transmissible respiratory infection caused by influenza viruses A and B, poses a persistent threat to global public health due to its high mutation rate, ability to develop resistance to existing antiviral drugs, and capacity for rapid spread. Current treatment options, including four main classes of antiviral agents—adamantanes, neuraminidase inhibitors, RNA-dependent RNA polymerase inhibitors, and polymerase a Read More
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Discovery of New Natural Phytocompounds: The Modern Tools to Fight Against Traditional Bacterial Pathogens
Available online: 21 October 2024More LessOngoing competition between disease-causing bacteria and human hosts has resulted in the discovery of a wide array of antibacterials. The advent of antibacterials ushered in a promising period in the realm of microbiology, but its brilliance was short-lived and soon diminished. The excessive and incorrect use of antibacterials results in limited selection pressure on the targeted microorganisms, which in turn promotes the evol Read More
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Unwinding the Threads of Mesoporous Silica Nanoparticles as Cutting-Edge for the Management of Inflammation: An Updated Review
Authors: Priya Dhiman, Sukhbir Singh, Sandeep Arora, Neelam Sharma, Ritu Gulia and Ladli KishoreAvailable online: 11 October 2024More LessBackground Inflammation serves as a protective response to combat cellular and tissue damage. There is currently a wide array of synthetic and traditional therapies available for the treatment of inflammatory diseases. However, it is necessary to create a drug delivery system based on nanotechnology that can improve the solubility, permeability, and bioavailability of current treatments. Mesoporous silica nanoparticles ( Read More
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Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression
Authors: Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin and Bin WuAvailable online: 09 October 2024More LessObjective This study aimed to explore the effects of Jiangu Recipe (JGR) on chondrocyte responses under tert-Butyl hydroperoxide (TBHP)-induced oxidative stress, specifically focusing on apoptosis and extracellular matrix (ECM) degradation. Methods Chondrocytes were treated with varying JGR concentrations, and cell viability was assessed. The impact of JGR on TBHP-induced apoptosis and protein expression levels of apopt Read More
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Bridging the GAP: Probiotic Douches Redefining the Feminine Hygiene
Authors: Akash Kumar, Sadique Hussain, Nitya Srivastava, Gurvinder Singh, Monica Gulati and Rajesh KumarAvailable online: 09 October 2024More LessVaginal douching is a centuries-old practice which is still in use, especially among adolescents. “Probiotic douches” are the vaginal douches that are formulated with probiotics and are intended to restore or maintain the vaginal microbiome balance. Probiotic douches are a new type of feminine hygiene product that claims to promote a balanced vaginal microbiome and improve overall well-being. However, the evidence supporti Read More
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