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image of In-vitro, In-vivo and Molecular Docking Studies on Dietary Supplement Containing Polar and Non-Polar fractions of Persea Americana for 
Management of Diet-related Chronic Diseases

Abstract

Background

Diet-related chronic diseases, such as cardiovascular diseases, obesity, diabetes, autoimmune diseases and cancer, are largely preventable with a healthy diet and lifestyle. Therefore, searching for dietary supplements rich in antioxidant and anti-inflammatory phytochemicals for the prevention and/or management of diet-related chronic diseases is an important strategy for controlling these diseases to reduce healthcare costs and sustain development.

Objective

The aim of the current research was to prepare dietary supplements from avocado fruit pulp [AFPDS] and evaluate their potential against various diet-related chronic diseases through , , and molecular docking studies.

Methods

Volatile compounds of avocado pulp were evaluated, and the total phenolic compounds, fatty acids, and phytosterols profiles of the AFPDS were determined.

Results

D-limonene, methyl propanoate, isobutyl propanoate and pentanol were the principal volatile compounds in the avocado pulp. Total phenolic and flavonoids were present in the AFPDS by 9.65 mg GAE/g and 6.87 mg CE/g, respectively. Chlorogenic acid and cinnamic acid were the major and minor identified phenolic compounds in AFPDS, respectively. Oleic acid [75.06%] and β-Sitosterol [2.19%] were the highest fatty acid and phytosterol present in AFPDS, respectively. AFPDS recorded anti-inflammatory activity against nitric oxide [NO] production in RAW264.7 macrophages by 98.2µg/ml [IC50] and 164.8µg/ml [IC90]. AFPDS showed significant anti-inflammatory activity against carrageenan-induced rat paw edema. AFPDS showed antioxidant activity against DPPH and ABTS by 8.67 mg TE/g and 6.14 mg TE/g. AFPDS possessed anti-cancer activity against MCF7 and HPG2 at10.8µg/ml and 40.5µg/ml, respectively. AFPDS exhibited anti-diabetic activity as an inhibitor of α-amylase and -glucosidase by26.35±0.77μg/ml and 0.55±0.163mg/ml, respectively. Molecular docking studies revealed high binding affinity of different active compounds present in AFPDS with cyclooxygenase-2, glutathione peroxidase, -glucosidase and B-cell lymphoma-extra-large proteins.

Conclusion

AFPDS can be considered a new agent for the prevention and treatment of diet-related chronic diseases, such as diabetes and cancer, due to its anti-inflammatory, antioxidant, anticancer, and anti-diabetic activities, as demonstrated through , , and molecular docking studies.

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2025-03-26

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/content/journals/cpb/10.2174/0113892010357755250227060845
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In-vitro, In-vivo and Molecular Docking Studies on Dietary Supplement Containing Polar and Non-Polar fractions of Persea Americana for 
Management of Diet-related Chronic Diseases
Bentham Science Publishers ; https://doi.org/10.2174/0113892010357755250227060845
/content/journals/cpb/10.2174/0113892010357755250227060845
/content/journals/cpb/10.2174/0113892010357755250227060845
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  • Article Type:     Research Article
Keywords: anti-diabetic ; Avocado pulp dietary supplement ; diet-related chronic diseases ; anti-inflammatory ; molecular docking ; anticancer

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