Current Organic Chemistry - Volume 22, Issue 7, 2018

Background: Chitosan thermoresponsive hydrogel is non-covalent crosslinked intelligent hydrogel. The compositions of the hydrogel determine its gelling property associated with particular structure-interaction effects. Simple and mild preparations as well as desirable bioactivities allow chitosan thermoresponsive hydrogels extensively applied in drug delivery and tissue engineering, especially the exciting proceeding in e Read More

Background: Chitosan-based nano-biocomposite has received more and more attentions in the past few years because of the outstanding merits that chitosan is a natural polymer with biodegradable and biocompatible. Objective: The purpose of the present study is to summarize the different preparation methods of chitosan-based nano-biocomposites, such as electrostatic interaction method, preparation of chitosan-based na Read More

Background: Regarded as biofunctional poly- and oligomers having much higher potential than cellulose in many fields, chitosan and its derivatives have become of great interest thanks to the recent progress in chitin chemistry. Chitosan, which is a natural- based polymer obtained by alkaline deacetylation of chitin, is an interesting bioactive polysaccharide composed of many reactive groups. Objectives: This gives huge possibi Read More

Background: Due to poor safety characterstics, viral vectors in gene delivery are usually limited in clinical application. Non-viral vectors have focused on the development of effective gene delivery carriers. As a promising non-viral carrier, chitosan (CS) is advantageous due to its biocompatibility, low toxicity and immunogenicity. Objective: The disadvantages such as low transfection efficiency and lack of celltargeti Read More

Background: Chitosan (CS) is a nontoxic and biocompatible natural polysaccharide with great development potential in the delivery of chemical drugs. However, further applications of CS are limited due to its inherent insolubility in neutral solution. Objective: The chemical modification of CS is of great significance for drug carriers, and the modification would not alter its fundamental skeleton but affords new or improved prop Read More

Background: Chitosan, a naturally occurring polymer, is a non-toxic, biocompatible, and biodegradable, and has drawn much attention in the recent years for its use as scaffold material either as alone or in a combination with other materials in tissue engineering. In addition, these chitosan-based scaffolds are able to bind bioactive factors, preserve cells phenotype, control gene expression, synthesize and depose tissue-specific ext Read More

Background: The microsphere prepared from chitosan, a natural polymeric material, has attracted considerable attentions due to the natural instincts of chitosan and microsphere structure. Objective: In the current review, the recent progress on the preparation and medical applications of chitosan microspheres would be introduced and summarized. Method: The methods for the preparation of CS microspheres were su Read More