Current Organic Chemistry - Volume 22, Issue 27, 2018

The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds Read More

Efavirenz is an anti-HIV drug categorized under Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). It is recognized as the first line drug of choice for treating HIV infections. Poor aqueous solubility of the drug (< 10 μg/mL) offers specific challenges in formulation design, leading to limited bioavailability of 40 to 50%. To address this issue, several drug delivery options have been adopted for Efavirenz with special em Read More

Thermal energy can be stored as sensible or latent heat. Phase change materials (PCMs) use latent heat storage, offering great energy density over a limited temperature range. Organic materials, such as paraffins, fatty acids, polymers, sugar alcohols and their eutectic mixtures can be used as PCMs for applications near room temperature, due to their high liquid-solid enthalpy. Inorganic salts and salts hydrates can also Read More

Biofilm is the advantageous mode of growth for microorganisms, where dynamic microbial communities are irreversibly attached to a solid substratum, as well as to each other. The residing bacterial cells in the biofilm embedded in a self-made matrix of extracellular polymeric substances, which makes the community up to 1,000-times more resistant to detergents and antibiotics than planktonic cells. Dental car Read More

Hantzsch pyridines are conspicuous nitrogen-holding heterocyclic compounds and different procedures have been worked out for their synthesis. Hantzsch pyridines have a variety of methods for their synthesis but according to the literature survey, two pot synthetic route is more developed than one pot due to a vast variety of catalysts becoming cheap, economical, eco-friendly and recyclable. However, researchers synthesi Read More