Current Organic Chemistry - Volume 22, Issue 9, 2018

Background: The term chlorophyll c encompasses a small but heterogeneous group of algal pigments, characterized for being porphyrins rather than chlorins. Chlorophylls c are protochlorophyllide-type compounds that differ in their peripheral substituents. Mass spectrometry has contributed to the structural elucidation of chlorophylls c, often in parallel with the development of soft ionization techniques. Objective: To provide c Read More

Background: Non-allomerized chlorophylls a and b are part of a great diversity of environments: senescent and ripened vegetal tissues, processed foods, sediments, fecal pellets, etc. Consequently, the articles characterizing their mass spectrometry behavior belong to a variety of disciplines. Objective: To compile in a single review all the information published related to mass spectrometry of 26 chlorophyll derivatives, includin Read More

Background: Phototrophic prokaryotes inhabit a diverse array of environments on our planet and also contain a wide range of chlorophylls and bacteriochlorophylls, encompassing both chlorin and bacteriochorin structures. Objective: This review considers the ecological niches of the phototrophic prokaryotes, together with the mass spectrometric study of their chlorophyll and bacteriochlorophyll pigments. Methods: A Read More

Objective: This mini-review highlights the highly sensitive ¨soft¨ ionization mass spectrometric methods applied to chlorophyll chemistry. Method: This is a first-hand review of the important developments made over the mass spectrometry of chlorophyll a and chlorophyll b derivatives. Results: The review covers the capacity of the mass spectrometric techniques to solve problems, e.g., assignment of stereochemical configurati Read More

Biginelli compounds are one of the most important heterocyclic systems that play an important role in medicinal chemistry. It has been proved that the biological activities of these compounds are dependent on the absolute configuration of the C4 atom of the heterocyclic ring, and thus the oxidative dehydrogenation reaction can affect their biological and pharmaceutical activities. In this review, the oxidation methods of vari Read More

Formerly, an unexpected acyl migration of 1-methylidene-3,4-dihydroisoquinoline- 2(1H)-yl-methanone derivatives was observed, and on this basis a microwave assisted synthetic method was developed for the preparation of members of the 2'-(3,4- dihydroisoquinoline-1-ylidene)-1-ethan-1-one family, potential CB2 receptor agonists and PDE7 inhibitors. The reaction mechanism was studied with experimental and theoretical met Read More

Background: In the past decades, mechanochemical organic synthesis has become an attractive technique for solvent-free synthesis, which avoids the usage of harmful solvents and production of toxic wastes. This method has been utilized to promote the efficient formation of carbon–carbon and carbon–heteroatom bonds. The mechanochemical synthesis of macrocyclic molecules, rotaxanes and covalent organic frameworks Read More

Background: Neoponkoranol is one of de-O-sulfonated sulfonium salts isolated from Genus Salacia showing potent inhibitory activities against α-glucosidases. In previously reported synthetic strategies, the two key coupling partners should be firstly constructed from different starting materials and the following coupling reaction is usually time-consuming. Thus, a more efficient and scalable synthetic protocol would be Read More