Current Organic Chemistry - Volume 22, Issue 23, 2018

Halides, as important starting materials, construct complex structures and notable structural motifs in natural products and manufactured drugs. Transition-metalcatalyzed halides formation has emerged as a particular approach to generating organohalides, which is predictable to compete as an alternative to more established synthetic methods. This review attempts to provide different methods to catalyze the synthesis of org Read More

Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen-containing heterocyclics as possible chemothera Read More

The benzimidazole moiety is a privileged heterocyclic nucleus which has been used broadly in medicinal chemistry. Benzimidazole derivatives are useful building blocks for the development of important compounds of biological and therapeutic interest. The developments of facile synthetic routes to achieve access to these molecules are of prime interest, therefore synthetic organic chemists focused to invent an efficient m Read More

A series of triazolo-pyridazinone derivatives were prepared through the standard click reactions of 4,6-diphenyl-2-(prop-2-yn-1-yl)pyridazin-3(2H)-one 1, possessing a free terminal alkyne group with a selection of substituted aryl azides 2-9. The cytotoxicity and in vitro anticancer investigation of the new compounds were conducted against four different human tumor cell lines, including breast adenocarcinoma MCF-7, hepatoc Read More

A series of resorcinarene-PAMAM-porphyrin dendrimers was synthesized. The nanostructures were characterized by IR, 1H and 13C NMR, UV-vis absorption, electrospray ionization and MALDI-TOF mass spectrometry. The morphological properties were characterized by High-Resolution Transmission Electron Microscopy (HRTEM). The distance between the resorcinarene group and the porphyrin group was variable: two di Read More