Current Organic Chemistry - Volume 22, Issue 20, 2018

Rapid developments in protein engineering, immunology and pharmaceutical research have led to immense demands for synthetic polypeptides. Several polypeptides synthesizing strategies are now available, among which solid-phase synthesis and solution- phase synthesis are especially relevant. This review pretended to compare these two synthesizing strategies with no bias, appreciate their advantages, drawbacks and Read More

Background: Heterocyclic compounds have received much attention due to their versatile applications in the field of medicinal chemistry as well as organic chemistry. Objective: The main objective of this review is to give an overview of the recent application of β-cyclodextrin catalyzed one–pot multicomponent reactions for the synthesis of different assemblies of heterocycles. Method: In this review, we have summarized the on Read More

In several cases, the occurrence of methylation on oxygen site of an organic molecule is not a straightforward process. Most of the O-methylations take place with hydroxyl groups of carboxylic acids, phenols, and alcohols, affording methyl esters, aryl methyl ethers, and alkyl methyl ethers, respectively. Polysaccharides are polyhydric alcohols that have received special interest for methylation purpose. A number of methylati Read More

Atorvastatin is an aromatic compound that acts selectively in the liver as an inhibitor of HMG-CoA reductase and cholesterol synthesis. The iodination of aromatic compounds has been widely applied for the preparation of potential pharmaceuticals and bioactive molecules. Herein, an iodinated atorvastatin was synthesized using chloramine- T (CAT) intermediate via an electrophilic substitution reaction. The obtained pr Read More

An efficient and ligandless catalytic system was developed for the Suzuki- Miyaura coupling reactions of potassium aryltrifluoroborates in pure water. Using TEAB as additives, Pd(OAc)2 was found to be very efficient for the Suzuki-Miyaura coupling of potassium aryltrifluoroborates with various aryl and heteroaryl bromides in pure water with Na2CO3 as a base, affording the desired products in moderate to excellent yields.