Current Organic Chemistry - Volume 22, Issue 28, 2018

Benzothiazole (BOT), the heterocyclic system consists of five-membered thiazole ring fused with the benzene ring. It is a very potent molecule because of its numerous pharmacological activities like anti-tumor, anti-microbial, anti-inflammatory, anticonvulsant, anti-diabetic, neuroprotective, calcium channel antagonist etc. Due to its extensive biological activities, it is still an interested area of research. Many scientists have dis Read More

[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of conc Read More

This review collects for the first time enantioselective domino reactions promoted by chiral green copper catalysts, covering the literature since the beginning of 2006. It is divided into two parts dealing successively with asymmetric two-component domino reactions and three-component processes. The first part is dedicated to twocomponent asymmetric domino reactions, including Michael-initiated processes, domino rea Read More

Background: The synthesis of 6-membered pyrrololactams has been studied extensively over the past two decades, in particular because of the diverse biological activities ascribed to many marine-derived alkaloids with pyrrololactam structure. Consequently, many efforts to develop routes of synthesis for the preparation of a large variety of functionalized pyrrololactams have been reported. Objective: A summary of the pro Read More

A reaction of 2-amino-N'-arylbenzamidines with triethyl orthoformate, orthoacetate and orthopropionate leads to quinazolin-4(3H)- imines. These compounds transform to 4-arylaminoquinazolines by heating in acetic acid according to the Dimroth rearrangement mechanism. Unexpectedly, these imines heated in ethanol gave mixtures of 4-arylaminoquinazolines and 4- ethoxy-quinazoline.