Current Organic Chemistry - Volume 22, Issue 25, 2018

Background: The synthesis of seven-membered heterocycles is a growing field in order to explore their biological and pharmaceutical importance. 1,3,4- Thiadiazepinesare are a notable class of heterocyclic compounds with remarkable biological importance. 1,3,4-Thiadiazepines have been reported to have an exceptional range of biological activities such as anti-HIV, biocidal, antimicrobial and generating agents and used in Read More

Allylic and benzylic brominations are of paramount importance in organic synthesis. They give rise to many valuable synthons leading to the production of fine chemicals, agrochemicals and pharmaceuticals. A great many bromination methods have thus been developed to conduct the titled reactions under different circumstances. The need for environmentally benign conditions to circumvent drawbacks associated with Read More

Chiral ligands perform the vital role in enantioselective transition-metal mediated reactions. The accomplishment of N-based chiral ligands is due to the inherent air stability, electron-rich, neutral ligands for homogeneous catalysis. Above all, the easy access and diversity in the core structure as a template for asymmetric reactions led to the experimentation and establishment of diverse chiral N-based backbone as stereodirecting Read More

The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer patients. Since the ancient time, natural products and/or their derivatives have become continuous sources of leading commercialized pharmacological compounds that are used as antibiotics and antitumor agents. An unexplored source of natural produc Read More

Five different model reactions (photodecarboxylation, inter- and intramolecular [2+2] cycloadditions, TiO2 photocatalytic reduction and type II photooxygenation) were investigated in the advanced Vapourtec UV-150 photo reactor with their conversion and throughput potentials reported. Compared to known batch reactions in laboratory reactors, significantly higher calculated productivities were achieved despite a rather Read More