Current Organic Chemistry - Volume 22, Issue 3, 2018

The present review summarizes the up to date developments on organobicyclo- bases namely 1,4-diazabicyclo[2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) and 1,5,7-triazabicyclo-[4,4,0]-dec-1-ene (TBD) catalyzed one-pot multi-component synthesis of biologically relevant heterocycles.

The combination of advantages of multicomponent reactions (MCRs) and magnetic nano catalysts is going to be an emerging and strategic area and is an ideal blend for the development of sustainable methodologies in organic synthesis in green and benign media. This review focuses on the synthesis, functionalization, and application of organic-inorganic hybrid magnetic nanoparticles as novel task-specific catalysts on multic Read More

Background and Methodology: A series of pyridazino[5,4,3-de][1,6]naphthyridine derivatives of a new ring system (11a-k, 29a,b) were synthesized via novel multicomponent reaction under high pressure from 2-phenylhydrazono derivatives (1a-d), malononitrile and aromatic aldehydes (10a-h) or acetone (28). Conclusion: The structure of reaction products could be established by X-ray crystallography and a mechanism of reacti Read More

Methyl α-cyano β-(hetero)aryl acrylates are excellent substrates for CAL-B catalyzed aminolyses. However, upon concatenation of the substrate Knoevenagel condensation (of (hetero)aryl carbaldehydes and methyl cyano acetate) and the CAL-B catalyzed aminolysis, an interesting bifurcating domino Knoevenagel-CAL-B catalyzed aryl methylaminolysis/hydrolysis reaction furnishing either amides or salts in the sense of a three- Read More

Background: Spiro[4.5]decenones are privileged structural motifs occurring in various biologically active natural and unnatural compounds. Moreover, they are very important intermediates in organic synthesis. Therefore, the development of novel onepot protocols for the synthesis of these synthetically challenging spirocyclic compounds that benefit from simple, inexpensive, and readily available starting materials con Read More

Background: In the last few decades, research into boron-containing compounds (BCCs) has notably increased in medicinal chemistry. Multiple maladies are now targeted by means of BCCs. Since bioinformatics tools have become a common and efficient methodology for drug design and materials science, their application to the study of BCCs is expected to intensify. Objective: This review compiles the use of computation Read More