Current Organic Chemistry - Online First

Heterocyclic scaffolds, particularly indole and thiazole compounds, are revolutionizing the treatment of lung diseases due to their structural diversity and broad therapeutic potential. Their ability to target multiple biological pathways positions them as powerful tools for developing innovative treatments for lung disorders, particularly lung cancer. This review systematically explores recent advances in the synthesis a Read More

This review examines the reactivity of bis(α-cyanoacetamides) attached to various spacers in producing heterocyclic and macrocyclic molecules. Bis(α-cyanoacetamides) contain two electrophilic and three nucleophilic sites, allowing for multiple coupling reactions. They are regarded as potent chemical reagents capable of producing various heterocyclic derivatives with potential biological applications. The current review covers Read More

This review investigates the reactivity of cycloheptane-based β-ketoesters in producing α-functionalized derivatives. Cyclic β-ketoesters are a versatile chemical reagent that can react with suitable electrophiles to produce a variety of α-functionalized derivatives with excellent synthetic potential and promising biological properties. This review covers all reports on α-functionalization of cycloheptane-based β-ketoesters, in Read More

Efficient synthesis of heterocyclic has always been a very important task in drug discovery. Most of the drugs contain heterocycles to provide an interface between chemistry and biology. Among the various heterocyclic compounds, quinazoline, a heterocyclic compound, offers multiple advantages like pyrimidine, pyridine, piperidine, imidazole, morpholine, quinoline, purine, etc. Many research groups have demonstrated Read More

Phenanthrenes and their dihydro derivatives have attracted considerable attention due to their widespread occurrence in natural products and pharmaceuticals with biological activities, which have led to their application in the treatment of microbial or viral infections, allergies, cancer, and malaria. Nowadays, the transitional metal-catalysed reactions are useful approaches for the synthetic transformation of organic compo Read More

Mangiferin always draws the attention of traditional as well as modern medicinal chemists because of its ease of chemical derivatization and diverse biological activities, including anticancer, anti-inflammatory, neuroprotective, antidiabetic, analgesic, antimalarial, anticonvulsant, laxative, cardiotonic, hemopoietic, antioxidant, antimicrobial, antipsychotic, anticoagulant, and antihypertensive properties. This review focuses o Read More

N-Chlorosuccinimide (NCS) is a five-membered N-containing heterocyclic molecule. This is a versatile reagent and is successfully employed for different types of reactions. Initially, this was employed for chlorination only but soon became an excellent reagent for many reactions, including halocyclizations, functional group transformations, formation of carbon-carbon bonds, etc. This review article covers representative app Read More

Indoles are critical in natural amalgamation for their flexible jobs in drugs, regular items, and material science, exhibiting huge pharmacological and compound reactivity. Due to their versatility and high reactivity, nitroalkenes are essential electrophilic partners in organic synthesis. While indoles and nitroalkenes are used in both Michael addition and Friedel-Crafts alkylation for producing carbon-carbon bonds, the catalyst t Read More