Current Organic Chemistry - Volume 22, Issue 2, 2018

The aim of this review is to provide a detailed account of the total synthetic approaches toward glycosylated Macrolide A. Mandelaide A was isolated from Lissoclinum Ascidian species found in Algoa Bay, South Africa and has been reported to exhibit potent cytotoxicity against a human lung cancer and a mouse neuroblastoma cell line. We have summarized the maneuvers in each paper by graphically detailing the synth Read More

Background: 2,2-Disubstituted-1,3-dicarbonyls, including iodonium ylides, indanedioneketene precursors, sulfur ylides, 2,2-difluoro-1,3-diketones, 2,2-dihydroxyl- 1,3-diketones and cyclopropyl 1,3-dicarbonyls, are important intermediates in organic synthesis. Methodology: They are used in the preparation of various amides, benzofurans, furanones, quinones, and so on. However, there is no review to summarize their multiperfo Read More

Background: Alkaloids are a diverse group of naturally occurring secondary metabolites which exhibit various pharmacological properties. They have been synthesized via various synthetic routes in order to study their medicinal efficacy and structure activity relationships. Methodology: Keeping in view the pharmaceutical significance of this class of compounds, the present review has been written with a focus on the syn Read More

Background: The reaction of aryl halides or vinyl halides with activated alkenes in the presence of Palladium-catalyst along with a base for the formation of the C-C bond is called the Heck reaction. This reaction has been employed extensively in the synthesis of heterocyclic compounds. Methodology: We have highlighted these applications in 2010. Conclusion: This review aims to cover the recent application of the Heck r Read More

β-lactams have attracted a significant attention due to their potential biological activities and wide variety of synthetic applications. Developing novel and efficient methods for construction of functionalized β-lactams has been the subject of a number of papers in recent years. N-Propargyl amines/amides are one of the most specific class of alkynes having diverse reaction patterns. It is well known that they can undergo a n Read More