Current Drug Therapy - Current Issue

The nasolacrimal channels drain the medication from the pre-corneal area, causing the majority of the ophthalmic medication to be quickly removed following topical instillation. Over the past thirty years, newer medical techniques, such as in situ gel, nanoparticle, liposome, nanosuspension, microemulsion, iontophoresis, and occuserts have been created in an effort to overcome these challenges. These met Read More

The emergence and spread of Antimicrobial Resistance (AMR) pose a grave threat to global public health. In the pursuit of innovative solutions, targeting the immune cell CD4 receptors (iCD4) has gained momentum as a potential strategy for combating AMR. This abstract explores drug delivery strategies aimed at harnessing iCD4 receptors to enhance the efficacy of antimicrobial therapies. The CD4 receptor, primarily f Read More

This in-depth analysis examines the revolutionary potential of nanostructures, particularly niosomes, in boosting Clotrimazole's therapeutic effectiveness for dermatological applications. A common antifungal drug called clotrimazole suffers significant problems with solubility, bioavailability, and penetration. Niosomal gels in particular, which are nanostructured drug carriers, have emerged as ground-breaking Read More

Globally, lung cancer ranks among the most frequent forms of tumor. The survival rate for people suffering from lung tumors after five years is only 20%, despite novel treatment options such as immunotherapy. Current therapies cause severe off-target effects and acquired drug resistance to explain the low survival rate. Identifying and developing new therapeutic approaches for lung cancer patients is crucial to improving t Read More

Currently, a significant proportion of older individuals have demonstrated connections between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM). Emerging evidence from cohort studies, clinical data, and preclinical meta-analyses reveals that T2DM patients have an increased risk of developing PD, often accompanied by more severe disease progression. These two chronic conditions are believed to share com Read More

Parkinson’s disease (PD) is a prominent area of study within the field of neurology, particularly neurodegenerative disease (ND). The peak incidence of PD occurs in those over the age of 45, and the disease’s prevalence rises continuously with age, the incidence of PD has skyrocketed over the world. A slow decline in neural function characterizes NDs, but the pathophysiological mechanisms behind this decline remain elusive. B Read More

It was asserted that the manufacturing of liposomes, which was first disclosed in 1961, was a useful technology for drug encapsulation. Furthermore, there are several cosmetic items on the market now that include liposomes. The liposomes are novel drug carrier systems due to their similarity in lipid composition with the epidermal membrane. As a result, they penetrate the epidermis to a greater extent, showing Read More

Gold Nanoparticles (GNPs) have emerged as a novel technology in the field of targeted delivery systems, offering promising solutions for site-specific disease treatment. These nanoparticles possess unique physicochemical properties, such as controlled size, shape, and surface chemistry, which enable precise manipulation for enhanced therapeutic efficacy. The biocompatibility and ease of functionalization of GNPs facilitat Read More

Atopic dermatitis (AD) is a non-fatal, non-communicable, chronic skin inflammatory condition marked by itching, lesions, and skin barrier dysfunction. As per the International Eczema Council, as of 2022, more than 200 million people were suffering from AD, with the disease burden reported highest in children. Environmental factors, genetic predisposition, and lifestyle have been found to be essential factors in trigge Read More

Obesity is a pressing global public health challenge, recognized as a major risk factor for chronic diseases, such as diabetes, cardiovascular conditions, and cancer. The rising obesity rates necessitate effective and safe therapeutic interventions. Despite the availability of FDA-approved drugs for long-term weight management, these pharmacological treatments often entail significant side effects and high costs, leading t Read More

BackgroundFood-drug interactions caused by dietary alkaloids like piperine may significantly impact medication metabolism and excretion. In this study, we studied piperine's effect on sitagliptin's PD and PK.MethodsThe research assessed the food-drug interaction in normal and diabetic rabbits to demonstrate how piperine affects the PD and PK of sitagliptin. Piperine, sitagliptin, and sitagliptin plus piperine treatment were admini Read More

BackgroundIn recent years, there has been growing interest in the use of herbal products as complementary or alternative therapies for cancer patients. RVT has been extensively studied for its potential role in managing oxidative stress in cancer patients undergoing treatment.MethodsIn this study, the radioprotective effects of Resveratrol (RVT) (200 mg/kg) were evaluated in the brain tissues of rats after Radiation Therap Read More

BackgroundLornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID) with strong analgesic properties; however, its short half-life necessitates frequent administration for sustained efficacy.ObjectiveThe objective of the present study was to identify critical formulation parameters affecting sustained release Eudragit RSPO microsphere of lornoxicam employing the concept of design of experiments.Meth Read More

BackgroundPropolis (PR) is used as a health supplement and is widely used in foods and drinks in many parts of the world. This study aimed to know the possible reproductive toxicity effect of the antithyroid drug carbimazole (CZ) in adult female albino rats and to evaluate the possible protective role of Iraqi PR.MethodsTwenty-four adult female albino rats were randomized into four groups: control, PR, CZ, and PR + CZ. Rats were Read More

BackgroundEpilepsy is a neurological disorder characterized by a decreased level of vitamins and endogenous antioxidants and an enhanced level of oxidative stress.ObjectivesWe designed this study to define the effects of combining melatonin, vitamin D3 (Vit D3), and agmatine on seizures caused by pentylenetetrazole (PTZ) in male NMRI mice.MethodsThe experimental groups were as follows: the first group was administer Read More