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20 results
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Preparation, Evaluation, In vitro Anti-diabetic and Stability Studies of Glibenclamide Loaded Cocrystals
Authors: Jyoti Malik, Anurag Khatkar and Arun NandaAvailable online: 14 January 2025More LessBackground Glibenclamide (BCS Class–II .Drug) has poor solubility and high permeability. In the co-crystallization technique, drugs are combined with a suitable coformer via H- bonding. Glibenclamide cocrystals have been prepared with various coformers but glibenclamide cocrystals with vanillic acid have not been prepared yet. Objective To prepare glibenclamide cocrystals with vanillic acid coformer and evaluate them us Read More
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Comprehensive Insights into Cephalosporins: Spectrum, Generations, and Clinical Applications
Available online: 17 December 2024More LessCephalosporins, a widely utilized class of antibiotics in clinical settings for bacterial infections, are the focus of this critical analysis. This examination aims to provide a comprehensive description, encompassing their range, generational distinctions, and therapeutic applications. Renowned for their versatility against both Gram-positive and Gram-negative bacteria, cephalosporins have evolved over generations, enhancing efficacy a Read More
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Exploring Therapeutic Potential of Hydrotropic Solid Dispersions of Hesperidin and Naringenin for the Management of Diabetes and Obesity
Available online: 17 December 2024More LessThe preclinical antidiabetic and anti-obesity potential of hydrotropic solid dispersions of hesperidin and naringenin was investigated in streptozotocin [STZ]/nicotinamide [NIC]-induced diabetic rats on a high-fat diet. The hydrotropic solid dispersions showed significant glycemic control, insulin sensitivity, and lipid profiles while reducing body weight, adipose tissue mass, and inflammatory markers. These formulati Read More
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Autism Spectrum Disorder: Clinical and Genetic Aspects
By Shalu ShuklaAvailable online: 02 December 2024More LessAutism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by challenges in social communication and the presence of repetitive behaviors and restricted interests. It is acknowledged as a complex, multifactorial disorder influenced by both genetic and non- genetic factors. Recent advancements in neuroimaging studies have provided valuable insights into the observable changes in the brains of indi Read More
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A Comprehensive Review of the Phytochemicals, Nutritional Values, and Therapeutic Applications of Albizia lebbeck
Authors: Aishwarya Bajpai, Pranay Wal, Ashish Srivastava, Anil K. Yadav and Ateet SrivastavaAvailable online: 02 December 2024More LessPlants have been a source of medicinal phytoconstituents since ancient times and the knowledge has passed through generations of medicinal use. Medicinal plants contain not one but an amalgamation of various Phyto-derived moieties that are therapeutically active. One such plant that has come into light for its various employabilities is Albizia lebbeck, more commonly known as Siris. It is mainly grown in the Indian subconti Read More
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Plant-Derived Antidiabetic Agent: A Green Prevention Strategy
Available online: 15 November 2024More LessOne component of metabolic syndrome is diabetes mellitus. In recent years, the prevalence of diabetes has increased. Drugs produced chemically are used to reduce the negative effects of diabetes mellitus and its repercussions, which include weight gain, gastrointestinal problems, and heart failure. However, medicinal plants may provide an accurate source of drugs that combat diabetes. This paper aims to identify the poten Read More
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A Methodical Review of Intranasal Delivery of Nanocarriers for the Treatment of Glioblastoma: An Emerging Therapeutic Option
Authors: Pankaj Popli, Monika, Pragi, Varun Kumar, Deepanshu Sharma, Shrikant, Shabnam Kumari and Deepak GargAvailable online: 15 November 2024More LessGlioblastoma multiforme (GBM) is responsible for about half of all primary malignant tumors in the central nervous system (CNS). Nanotechnology and nanocarrier-based drug delivery may prove to be an asset in the ongoing fight against the difficulties associated with treating GBM. Obstacles to effective drug delivery in GBM treatment include prolonged blood circulation, sufficient BBB transit, effective internalization, and contr Read More
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Influenza (Flu) and Vaccination related Knowledge & Attitudes among the General Population of UAE
Authors: Ebtehal Al Sheikh and Syed Wasif GillaniAvailable online: 11 November 2024More LessBackground Influenza is one of the most common airborne infections globally. According to the World Health Organization (WHO), influenza leads to 3 to 5 million cases of severe illness each year, with 290,000 to 650,000 respiratory deaths annually, positioning it as a significant public health threat. Objective This study aims to evaluate the knowledge and attitudes toward influenza and vaccination among the general populati Read More
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Exploring the Multifaceted Potential of Kigelia africana: Journey from Ethnomedicine to Cosmeceutical
Authors: Khushbu Patel, Rashmi Saxena Pal, Yogendra Pal, MVNL Chaitanya, Deepti Katiyar and Preeti SrivastavaAvailable online: 04 November 2024More LessSince ancient times, Indian Balam Kheera or Kigelia africana sausage trees have been utilized to heal a variety of human afflictions. Ethnobotanists have documented the traditional uses of K. africana, which include the management of skin conditions, cancer, and gynaecological problems. Scientists have been interested in assessing the bioactivity of plant components of K. africana. Numerous researchers have been most i Read More
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Current Nanotechnological Strategies for Delivery of Anti-Retroviral Drugs: Overview and Future Prospects
Authors: Salam Shanta Taher and Khalid Kadhem Al-KinaniAvailable online: 29 October 2024More LessGlobally, over forty million people are living with Human Immunodeficiency Viral (HIV) infections. Highly Active Antiretroviral Therapy (HAART) consists of two or three Antiretroviral (ARV) drugs and has been used for more than a decade to prolong the life of AIDS-diagnosed patients. The persistent use of HAART is essential for effectively suppressing HIV replication. Frequent use of multiple medications at relatively high do Read More
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A Comprehensive and Concise Review on Significance of Potent Peptide; Amyloid Beta (Aβ) in Progression of Alzheimer’s Disease
Authors: Namra Aziz, Pranay Wal, Yash Kumar Singh, Pankaj Kumar and Bhupendra SinghAvailable online: 23 October 2024More LessBackground A condition associated with neurodegeneration is termed Alzheimer's, characterized by mental as well as memory deterioration. Amyloid beta (Aβ) is a type of peptide that accumulates within the central nervous system and causes plaque, cerebral amyloid angiopathy (CAA), and neurodegeneration (loss of acetylcholine). These peptide forms have a major impact on neuronal damage. Objective Our goal is to Read More
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A Comprehensive Approach for Diabetic Foot Ulcer Management
Authors: Anusha Bakshi, Bijal Prajapati, Abhay Dharamsi and Krishna SompuraAvailable online: 22 October 2024More LessObjectives This study aims to evaluate the efficacy of a comprehensive management plan in the treatment of diabetic foot ulcers (DFUs). Evaluating the effects of wound debridement on the outcomes of diabetic foot ulcers, advanced dressings, blood sugar control, and offloading strategies are the main objectives. The study also intends to investigate the function of surgery in managing chronic ulcers and preventi Read More
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Fabrication and Characterisation of Oral Fast-Dissolving Film of Metoprolol Succinate
Authors: Achal Dingalwar, Anil Pethe, Darshan Telange and Umesh TelrandheAvailable online: 22 October 2024More LessIntroduction Oral, fast-dissolving films are an excellent alternative. The purpose of adopting the solvent casting approach was to create a compelling oral film. Methodology HPMC E15 and sodium alginate polymers were chosen based on their compatibility. The produced films were evaluated in terms of organoleptic characteristics, weight, thickness, folding durability, tensile strength, drug content homogeneity, surf Read More
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A Review on Film Forming Spray Technology in Wound Management
Authors: Sakshi Singh, Bijal Prajapati and Abhay DharamsiAvailable online: 21 October 2024More LessPurpose Skin is an important delivery channel for medications, providing both local and systemic effects. One kind of novel medication delivery technology that is administered topically to the skin is called a topical film forming system. The thorough analysis examines how film-forming sprays have revolutionized a variety of fields, including wound care and medicine. The goal is to present a thorough summary of the ass Read More
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Novel Pharmaceutical Interventions for Drug Targeting in Parkinson’s Disease
Authors: Simran Chaurasia, Sakshi Sharma Dogra, Md Sadique Hussain, Rajesh Kumar and Navneet KhuranaAvailable online: 17 October 2024More LessParkinson's Disease (PD) presents as a neurodegenerative disorder characterized by a gradual decline in brain function, typically advancing slowly over time in most individuals. However, as the disease evolves and impacts the Gastrointestinal Tract (GIT), the window for effective treatment response often becomes narrower for many patients. Recent advancements in medical science have spurred improvements in drug deli Read More
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Orexin Receptor System: Molecular Insights and Therapeutic Implications
Authors: Prachi Sharma, Gunjan Choudhary, Monika Sachdeva, Geetika Mehta and Rashmi TripathiAvailable online: 16 October 2024More LessNeuropeptide neurotransmitters, orexins, are produced in the lateral hypothalamus. They are extensively dispersed throughout the central nervous system, except the cerebellum and peripheral nervous system. Orexin works by attaching themselves to G-protein-coupled receptors: orexin receptor 1 (OXR1) & orexin receptor 2 (OXR2). They play a role in the regulation of energy homeostasis, appetite, sleep-wake cycles, an Read More
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Exploring Innovations in Transdermal Drug Delivery: Microneedle Technologies and the Latest in Patent Developments
Available online: 15 October 2024More LessIntroduction/Objective Microneedle technology has emerged as a promising approach for drug delivery, offering advantages such as improved patient compliance and enhanced therapeutic efficacy. This review aims to provide a comprehensive overview of recent advancements in microneedle-based drug delivery systems, emphasizing their potential to overcome limitations associated with traditional transdermal d Read More
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Revolutionizing Transdermal Patches: Navigating Clinical Challenges and Technological Progress
Authors: Shubham Malik, Chandan Sharma, Nishant Thakur, Bhupinder Kaur and Neeraj BainsalAvailable online: 08 October 2024More LessTransdermal patches, conceived to extend drug release, enhance bioavailability, and foster patient adherence, witnessed their inaugural approval by the USFDA in the 1980s. These patches, varying in size, constitute medicinal formulations with one or more active components that permeate the bloodstream through the skin. This review undertakes a comprehensive examination of recent strides in transdermal patch technolo Read More
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Role of Phytochemicals in the Management of Atopic Dermatitis: A Comprehensive Review
Available online: 02 October 2024More LessAtopic dermatitis is a chronic inflammatory skin condition that affects millions of people around the world. In the past decades, phytochemicals have gained attention for the treatment of atopic dermatitis due to their inflammatory, antioxidant, and immunomodulatory properties, which could be beneficial in alleviating the suffering associated with atopic dermatitis. Although various conventional treatments, such as imm Read More
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Beyond Creams and Gels: The Emergence of Emulgels in Pharmaceutical Science
Authors: Vikash Singh Bhadouria, Sushma Verma, Rashmi Mishra and Bhupinder KapoorAvailable online: 02 October 2024More LessBackground Emulgels combine the properties of emulsions and gels, offering a unique drug delivery system that enhances the solubility and stability of hydrophobic drugs. This study reviews recent advancements in emulgels and their potential in pharmaceutical applications. Objective To systematically review the current state of research on emulgels, focusing on formulation techniques, characterization methods, and the Read More
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