Current Drug Therapy - Volume 20, Issue 1, 2025

Ankylosing spondylitis (AS) is a complex autoimmune and auto-inflammatory disorder characterized by a gradual onset that can progress to spinal ankylosis over time. This chronic condition primarily affects the sacroiliac joints and the spine, often extending its influence to peripheral joints and extra-articular organs, including the eyes AS is associated with significant disability, along with comorbidities such as uveitis and inflamm Read More

Inulin (IN) is a prebiotic oligosaccharide reported in diverse sources of nature. The major sources encompass chicory, Jerusalem artichoke, onions, barley, garlic, rye, and wheat. The literature also reported its promising biological activities, e.g., antidiabetic, anticancer, antioxidant, immune-regulator and prebiotic for improving intestinal function, regulation of blood lipids, and so on. IN’s molecular flexibility, stabilization, and Read More

Resveratrol (RSV) is a polyphenol generated from plants. It is an organic substance that can be found in grapes, some berries, as well as other fruits and nuts. Numerous health benefits, such as anti-proliferative, anti-inflammatory, antidiabetic, anti-ischemic, anti-aging, steroidogenic effects, and antioxidant effects, have been demonstrated for it. Clinical trials show that it is technically safe to take resveratrol in doses Read More

In the current scenario, discovery of natural bioactive components can be considered as a major development in treating common ailments. One of the medicinally important herbs is Murraya koenigii. The biological functions are promoted by the leaves, fruits, roots, and bark of this beautiful plant. It is the carbazole alkaloids that promote most of the medicinal properties and contribute to the anti-oxidative properties as well. Read More

Epigenetic changes are important for controlling how genes are expressed and how cells work, and their misregulation has been linked to many diseases, including cancer. Targeting epigenetic modifiers has become a promising way to treat cancer, and it may also be useful outside of oncology. This review article goes into detail about the rapidly changing field of epigenetic-based therapies, with a focus on how they ar Read More

One of the classes of injective antidiabetic agents includes Glucagon-like peptide-1 receptor agonists (GLP-1RA) which ameliorate glycemia and numerous atherosclerosis-related factors in individuals prone to Type 2 diabetes mellitus (T2-DM) disorder.MethodsThe review paper targeted the role of GLP-1RA in managing DM. The literature published during the last decades in several data-based searches (PubMed, Scopus, Scie Read More

BackgroundPsoriasis is a chronic inflammatory and proliferative skin disorder characterized by redness and elevated patches covered in scaly, silvery-white skin. The National Psoriasis Foundation categorizes psoriasis into mild, moderate, and severe, impacting 2% to 5% of the global population. This article explores the types, development, and severity categories of psoriasis, delving into its pathophysiology. It also revi Read More

Osteoporosis (OP) remains a significant global health challenge, marked by high prevalence and considerable economic burden, yet effective therapeutic options remain limited. Central to the pathogenesis of OP is mitochondrial dysfunction, which adversely impacts bone formation and resorption. This review provides an in-depth analysis of the complex relationship between mitochondrial function and OP, elucidating crit Read More

BackgroundEpilepsy is the most common neurological disorder, characterized by abnormal, unpredictable, and recurrent seizures. In the alternative medicine system, Artemisia vulgaris has been used to treat epileptic symptoms since its inception. However, scientific evidence concerning its effect on the treatment of epileptic seizures is not available.ObjectivesThe objective of the study is to evaluate the anti-co Read More

IntroductionPepsin is a proteolytic enzyme which is widely used as a digestive aid. Its dose is 300 mg - 1 gm per day in divided doses. Its biological half-life is around 3.5 hrs. Pepsin is active only in the acidic pH of the stomach; its activity decreases tremendously in the basic pH. So, it is required to retain in the stomach for maximum proteolytic activity. The goal of the current effort is to develop and assess an oral controlled floati Read More