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Volume 20, Issue 3
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Background

Propolis (PR) is used as a health supplement and is widely used in foods and drinks in many parts of the world. This study aimed to know the possible reproductive toxicity effect of the antithyroid drug carbimazole (CZ) in adult female albino rats and to evaluate the possible protective role of Iraqi PR.

Methods

Twenty-four adult female albino rats were randomized into four groups: control, PR, CZ, and PR + CZ. Rats were orally treated for six weeks. Ovarian biochemical and histopathological analyses were performed.

Results

No change in appearance, no signs of toxicity, and no deaths of animals were reported throughout the study period. There was a significant body weight increase only in the PR group. The CZ group displayed a reduction in serum T3 and T4 levels and a rise in serum TSH levels compared to the control. Also, there was a significant decrease in serum T3, T4, and TSH levels after exposure to PR+ CZ compared to control. Exposure to 0.01mg/g body weight of CZ for six weeks results in a significant reduction of serum LH, FSH, and estradiol (E2) in female rats. At the same time, PR alone or with CZ was found to have no significant effect. Biochemical results were consistent with histopathological results.

Conclusion

Iraqi PR provides a protective effect against the reduction of serum sex hormones induced by CZ. Further studies are required to confirm this effect. PR has no effect on CZ activity in reducing thyroxin levels; however, PR might reduce the effects of CZ on TSH levels. Furthermore, PR alone demonstrated an elevation in the weight gain of animals compared to the control group.

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2024-05-27
2025-06-17

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References

  1. NguyenH.X. NguyenM.T.T. NguyenN.T. AwaleS. Chemical constituents of propolis from Vietnamese Trigona minor and their antiausterity activity against the PANC-1 human pancreatic cancer cell line.J. Nat. Prod.20178082345235210.1021/acs.jnatprod.7b00375 28783356
     [Google Scholar]
  2. AbdullahA.S. Effects of iraqi propolis, carbimazole and levothyroxine on the liver: histopathological studyin normal female rats.Indian J. Forensic Med. Toxicol.20211532065206910.37506/ijfmt.v15i3.15621
     [Google Scholar]
  3. Al-SerayG.H. AbdullahA.S. Iraqi propolis, carbimazole, levothyroxine and their propolis combinations effects on renal histopathological parameters in female rats.Braz. Arch. Biol. Technol.2022564
     [Google Scholar]
  4. SawickaD. CarH. BorawskaM.H. NiklińskiJ. The anticancer activity of propolis.Folia Histochem. Cytobiol.2012501253710.5603/FHC.2012.0004 22532133
     [Google Scholar]
  5. BazmandeganG. BoroushakiM.T. ShamsizadehA. AyoobiF. HakimizadehE. AllahtavakoliM. Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice.Biomed. Pharmacother.20178550351010.1016/j.biopha.2016.11.057 27889229
     [Google Scholar]
  6. KudoD. IndenM. SekineS. Conditioned medium of dental pulp cells stimulated by Chinese propolis show neuroprotection and neurite extension in vitro.Neurosci. Lett.2015589929710.1016/j.neulet.2015.01.035 25597290
     [Google Scholar]
  7. Gul BaykalirB. Tatli SevenP. GurS. SevenI. The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A.Anim. Reprod.201613210511110.21451/1984‑3143‑AR736
     [Google Scholar]
  8. CarosaE. LenziA. JanniniE.A. Thyroid hormone receptors and ligands, tissue distribution and sexual behavior.Mol. Cell. Endocrinol.2018467495910.1016/j.mce.2017.11.006 29175529
     [Google Scholar]
  9. La VigneraS. VitaR. CondorelliR.A. Impact of thyroid disease on testicular function.Endocrine201758339740710.1007/s12020‑017‑1303‑8 28429281
     [Google Scholar]
  10. SilvaJ.F. OcarinoN.M. SerakidesR. Thyroid hormones and female reproduction.Biol. Reprod.2018995907921 29767691
     [Google Scholar]
  11. Ben-RafaelZ. StruassJ.F.III Arendash-DurandB. MastroianniL.Jr FlickingerG.L. Changes in thyroid function tests and sex hormone binding globulin associated with treatment by gonadotropin.Fertil. Steril.198748231832010.1016/S0015‑0282(16)59363‑7 3111894
     [Google Scholar]
  12. PhillipsD.I.W. LazarusJ.H. ButlandB.K. The influence of pregnancy and reproductive span on the occurrence of autoimmune thyroiditis.Clin. Endocrinol. (Oxf.)199032330130610.1111/j.1365‑2265.1990.tb00870.x 2344696
     [Google Scholar]
  13. KrassasG.E. MarkouK.B. The impact of thyroid diseases starting from birth on reproductive function.Hormones (Athens)201918436538110.1007/s42000‑019‑00156‑y 31734887
     [Google Scholar]
  14. SakrS.A.R. MahranH.A. NofalA.E. Effect of selenium on carbimazole-induced testicular damage and oxidative stress in albino rats.J. Trace Elem. Med. Biol.2011251596610.1016/j.jtemb.2010.07.002 20832273
     [Google Scholar]
  15. HanJY LeeJM JungSY Comparison of agranulocytosis and anti‐neutrophil cytoplasmic antibody‐associated vasculitis caused by two antithyroid drugs: A pharmacovigilance study using the WHO international database.Fundam Clin Pharmacol2024fcp.1299110.1111/fcp.12991 38342499
     [Google Scholar]
  16. OkamotoY. TobeT. UedaK. TakadaT. KojimaN. Oral administration of Brazilian propolis exerts estrogenic effect in ovariectomized rats.J. Toxicol. Sci.201540223524210.2131/jts.40.235 25786527
     [Google Scholar]
  17. ElsheikhA.A. The propolis effect on chlorpyrifos induced thyroid toxicity in male albino rats.J Med Toxicol Clin Forensic Med201733
     [Google Scholar]
  18. CécereB.G.O. da SilvaA.S. MolosseV.L. Addition of propolis to milk improves lactating lamb’s growth: Effect on antimicrobial, antioxidant and immune responses in animals.Small Rumin. Res.202119410626510.1016/j.smallrumres.2020.106265
     [Google Scholar]
  19. ZawadzkiF. PradoI. MarquesJ. Sodium monensin or propolis extract in the diets of feedlot-finished bulls: effects on animal performance and carcass characteristics.J. Anim. Feed Sci.2011201162510.22358/jafs/66153/2011
     [Google Scholar]
  20. PrathimaP. VenkaiahK. PavaniR. α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period.Toxicol. Rep.2017437338110.1016/j.toxrep.2017.06.009 28959662
     [Google Scholar]
  21. AghajanovaL. LindebergM. CarlssonI.B. Receptors for thyroid-stimulating hormone and thyroid hormones in human ovarian tissue.Reprod. Biomed. Online200918333734710.1016/S1472‑6483(10)60091‑0 19298732
     [Google Scholar]
  22. HatsutaM. AbeK. TamuraK. Effects of hypothyroidism on the estrous cycle and reproductive hormones in mature female rat.Eur. J. Pharmacol.2004486334334810.1016/j.ejphar.2003.12.035 14985057
     [Google Scholar]
  23. FedailJ.S. ZhengK. WeiQ. KongL. ShiF. Roles of thyroid hormones in follicular development in the ovary of neonatal and immature rats.Endocrine201446359460410.1007/s12020‑013‑0092‑y 24254997
     [Google Scholar]
  24. SulaimanG.M. Ad’hiahA.H. Al-SammarraeK.W. Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo.Food Chem. Toxicol.20125051632164110.1016/j.fct.2012.01.022 22306915
     [Google Scholar]
  25. AbdulrethaS.D. AbdullahA.S. AL-Mozie’l MSG. Phytochemical effects of genistein and daidzein on sex hormones and corticosterone in female adult rats exposed to Chlorpyrifos.Toxicol. Environ. Health Sci.202214326126710.1007/s13530‑022‑00137‑6
     [Google Scholar]
/content/journals/cdth/10.2174/0115748855291155240517060342
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Protective Effects of Iraqi Propolis on Carbimazole-induced Reduction of Sex Hormones in Female Adult Rats
Curr Drug Ther 20, 415 (2025); https://doi.org/10.2174/0115748855291155240517060342
/content/journals/cdth/10.2174/0115748855291155240517060342
/content/journals/cdth/10.2174/0115748855291155240517060342
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  • Article Type:     Research Article
Keyword(s): carbimazole; estradiol; follicle-stimulating hormone (FSH); Iraqi propolis; luteinizing hormone (LH); TSH levels

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