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Volume 20, Issue 3
  • ISSN: 1574-8855
  • E-ISSN: 2212-3903

Abstract

Background

Lornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID) with strong analgesic properties; however, its short half-life necessitates frequent administration for sustained efficacy.

Objective

The objective of the present study was to identify critical formulation parameters affecting sustained release Eudragit RSPO microsphere of lornoxicam employing the concept of design of experiments.

Methods

The lornoxicam-loaded microspheres were prepared using a spray drying technique by optimizing the drug:polymer ratio(X1) and inlet air temperature (X2) using a 32 full factorial design. The percentage drug entrapment (Y1), percentage yield (Y2) and cumulative percentage of the drug dissolved at 18 hr (Y3) were selected as dependent variables. Microspheres were evaluated for percentage drug entrapment, mean particle size, percentage yield, drug release study and scanning electron microscopy (SEM).

Results

The optimized batch showed 84.51% drug release after 18 h with significantly higher drug entrapment and percentage yield. The optimization was further verified using overlay and desirability plots. The sustained release behavior of the drug from microspheres in GIT was displayed. The predicted and observed responses for the optimized formulation were in close agreement with the release profile of the drug.

Conclusion

The sustained release microspheres of lornoxicam may prove to be an effective analgesic with excellent anti-inflammatory potential.

© 2025 Bentham Science Publishers
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2024-05-10
2025-05-12

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/content/journals/cdth/10.2174/0115748855294736240502073344
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Fabrication and Characterization of Sustained-release Eudragit RSPO Microsphere of Lornoxicam by Spray Drying Technique
Curr Drug Ther 20, 407 (2025); https://doi.org/10.2174/0115748855294736240502073344
/content/journals/cdth/10.2174/0115748855294736240502073344
/content/journals/cdth/10.2174/0115748855294736240502073344
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  • Article Type:     Research Article
Keyword(s): eudragit RSPO; full factorial design; Lornoxicam; microsphere; non-steroidal anti-inflammatory drug; spray drying technique

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