Current Organic Chemistry - Volume 27, Issue 7, 2023

Heterocycles are organic compounds, the most important pharmaceutical skeleton widely distributed in nature. Many of them possess medicinal as well as pharmacological activities. Pyrroles are well-known five-member-privileged scaffolds with pharmaceutical potential. Pyrrole is the component of complex macrocycles, including porphyrins of heme and chlorophylls. Nowadays, the development of microwave-support Read More

Selenium metal acts as an essential nutrient in many selenoproteins. Various selenium- containing compounds are reported to possess a broad range of biological activities. In many commercially available drug molecules, selenium plays an important role. As a result, during the last two decades, organoselenium chemistry has expanded widely. A huge number of methods have been reported for the synthesis of structura Read More

Important progress in the transfer of organic reactions from solution conditions to automated solid-state synthesis was published a quarter of a century ago. Since then, ball-milling organic reactions have been slowly accepted by the chemical community as an additional synthetic tool, and the area of its application is rapidly expanding. These developments in mechanochemical synthesis are illustrated with selected literatur Read More

The increasing environmental pollution and its detrimental impact on the ecosystem made scientists develop new chemical strategies involving eco-friendly chemicals, solvents, catalysts, atom-economical procedures, and alternative energy sources. Among these, deep eutectic solvents (DESs) are primarily low-melting mixtures of quaternary ammonium salt and hydrogen-bond acceptors. Low toxicity, easy preparation, l Read More

Different intermediates are key molecules to synthesize high-added value bioactive and pharmacology molecules such as propargylamines may be synthesized in several ways using catalysts in homogeneous and heterogeneous conditions. This review presents the catalysts which are used in the A3, AHA, and KA2 coupling reactions to afford propargylamines. It also provides a classification of all the propargylamines known up to d Read More