Current Organic Chemistry - Volume 27, Issue 15, 2023

γ-lactams, bearing one or more chiral centers are important scaffolds and widely occur in many natural and synthetic products of clinical interest, but the synthetic approaches mainly focus on the preparation of rings that display trisubstituted carbons, whereas only a few examples concern the construction of chiral γ- lactams that display tetrasubstituted carbon atoms. However, in recent years, the broad potential of these latte Read More

Tuberculosis (TB) is the major cause of mortality around the world and one of the most common diseases linked to AIDS. Due to the emergence of multi-drug resistance, extensive drug resistance, and total drug resistance strains, TB has become a difficult disease to treat. Isoxazole scaffold shows a wide range of biological activities, including anticancer, antibacterial, anti-tubercular, antiviral, and anti-inflammatory activities Read More

Tetrazoles are important heterocycles in diverse branches of chemistry. Among the 5-substituted tetrazoles, the 5-amino derivatives are the most important by far as they show high chemical versatility and relevant applications in material chemistry, catalysis, agrochemistry, etc. Particularly in medicinal chemistry, they present a wide range of pharmacological properties. In the present review, we focus on the synthesis of 5- a Read More

Nature-derived thiols such as cysteine, homocysteine, and reduced glutathione play diverse and important roles in both plant and animal cells. In plants, they maintain redox homeostasis and affect photosynthesis and signal transduction processes. In animals, changes in the levels of biothiols have been linked to cardiovascular disease, Alzheimer's disease, neuropsychiatric disorders, or stroke. The detection of biothiols in biolo Read More

Ring contraction reaction is among the several vital strategies in organic synthesis that can provide very diversified and useful molecular architecture. Among these strategies, the oxidative ring contraction is of special interest as it can give a more straightforward way of designing and synthesizing several complex natural products, specifically the oxindole alkaloids and some newer oxindole analogs. Even this methodol Read More

Ruthenium-catalyzed olefin metathesis reactions were conducted in water with thermoresponsive block copolymers forming micelles. The block copolymers were prepared by living radical polymerization and consisted of a thermo-responsive and hydrophilic segments. The former segment included poly(N-isopropylacrylamide) or poly(N,N-diethylacrylamide), and the latter poly(sodium 4-styrene sulfonate), poly(sodium 2-acr Read More

Synthesis of a homologous series of 1-O-acyl xylose esters with long and very long acyl chains derived from fatty acids was performed via enzymatic esterification in one step using Candida antarctica lipase B. The effect of fatty acid chain length on the activity of the lipase was evaluated. Subsequently, the surface properties of the obtained products have been determined such as hydrophilic-lipophilic balance, c Read More

This report presents the synthesis of three innovative N-substituted 6α- piperazinomethyl-Δ4-3,17-diketo-steroids via the region-directed three-component condensation method. The compounds were produced from N-substituted piperazine derivatives and androst-4-en-3,17-dione (AD). Comprehensive physicochemical methods of analysis were employed to characterize the synthesized products. The study involved antib Read More

In previous studies on bioactivities, some extracts from Glinus oppositifolius possessed antimicrobial, antifungal, antiplasmodial, anti-inflammatory, anti-diarrhoeic, antihyperlipidemic, and hepatoprotective. However, information on the xanthine oxidase inhibitors' properties of G. oppositifolius is still limited. For the purpose of discovering new leads with potential α-glucosidase inhibition, the less explored plant G. oppositifolius has Read More