Current Organic Chemistry - Volume 27, Issue 1, 2023

The EGFR (Epidermal Growth Factor Receptor) regulates cell proliferation, survival, and differentiation. The EGFR is a cell surface receptor that belongs to the ErbB tyrosine kinase family. One of the most important targets for cancer therapy is EGFR inhibition. Because EGFR over-activation is seen in a wide range of malignancies, targeting EGFR and its downstream signaling cascades is a sensible and beneficial strategy in can Read More

Arylsilanes are the basic raw material for the synthesis of advanced silicone new materials such as phenylsilicone resin, phenylsilicone oil and phenyl silicone rubber, etc. The silicone polymers containing aryl groups were applied widely in the fields including electronics, and aerospace. In the past decades, arylsilanes have been widely used in organic synthesis, such as Hiyama coupling, C-N bond formation, synthesis of bia Read More

1,3-Benzazoles (BZs) are interesting compounds in medicinal chemistry. For instance, compounds with the BZ nucleus exhibit diverse biological activities and some of them are broadly utilized in clinical applications. In this sense, medicinal chemists aim at the development of new procedures to synthesize these kinds of molecules. The 2-aminobenzimidazole 2ABI derivatives, such as Enviradine (antiviral), Astemizole (antihista Read More

C-C bond formation in a regiospecific and atom economic manner has been a challenge, which was tried to be resolved through directing group and organometals-based C-H activation strategy. The C-H activation and its advantages are well explored in the field of organic chemistry, with the relevant mechanistic approach of the regioselective C-H activation of the aryl group. Organometals like Ru, Pd, Pt, Ni, etc. have been be Read More

Aims: In this study, the synthesis and biological activity of new 1,3,4-oxadiazole derivatives will be discussed. Background: Microbial contagion via different bacterial strains discomposes the healthcare system globally. In 2019 E. coli, S. aureus, K. pneumoniae, and S. pneumoniae were reported as the most bacteremia deaths causes. Over time, bacteria develop different ways to overcome antibiotic activity, causing multidrug res Read More