Current Organic Chemistry - Volume 27, Issue 20, 2023

Heterocyclic compounds are currently of great interest in pharmaceutical research. Many natural products, including vitamins, hormones, and antibiotics, contain heterocyclic compounds, and these substances have grown in importance. Heterocyclic thiazine derivatives have numerous pharmacological actions, including anticancer, antimicrobial, antipsychotic, anti-mycobacterial, anti-fungal, antiviral, antimycobacterial, Read More

Multi-component reactions have been used as an important synthetic strategy for the synthesis of diverse varieties of therapeutically useful heterocyclic scaffolds. High atom economy, one-pot reaction, and involvement of synthetically simple steps are some of the interesting features that make MCRs greener compared to conventional methods. The development of environmentally benign and eco-friendly synthetic m Read More

In many significant bioactive heterocyclic compounds, the six-membered ring pyrimidines play a major role as bioactive components. There is a lot of room for innovation in the fields of medicinal chemistry and the chemical industries because of the numerous pyrimidine synthesis methods and their varied reactions. The pharmacological effects of pyrimidine derivatives include anticonvulsant, antibacterial, antifungal, antiviral, a Read More

Schiff bases are dynamic organic compounds of bioactive importance, acting as flexible ligands and can form complexes with metals. Schiff bases along with their metal complexes have shown a large affinity towards DNA, which is one of the main targets of chemotherapeutics. DNA can join hands with these motifs in multiple ways, like covalent (crosslinking adducts) and non-covalent (intercalative or groove binding via electr Read More

Optically pure alcohols have a pivotal synthetic role, being key intermediates for numerous pharmaceutical agents. Therefore, the synthesis of optically pure alcohols is now becoming a foremost research field in both academia and industries. Herein, Bacillus thuringiensis has been described for the first time for the bioreduction of acetophenone to 1-phenylethanol. Five incubated bacillus species and a consortium w Read More

Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or inhibition is of potent therapeutic approach for treating various body disorders. In this work, we have synthesized a small library of pyrrolidine-tethered novel aurones 4(a-k) and structures validated by analyzing their IR, NMR (1H and 13C), and mass spectrometry data. The biological activities of the synthesized aurones were evaluated through in vitro Read More