Microwave-induced Reactions for Pyrrole Synthesis

Heterocycles are organic compounds, the most important pharmaceutical skeleton widely distributed in nature. Many of them possess medicinal as well as pharmacological activities. Pyrroles are well-known five-member-privileged scaffolds with pharmaceutical potential. Pyrrole is the component of complex macrocycles, including porphyrins of heme and chlorophylls. Nowadays, the development of microwave-supported synthetic strategies for such biologically relevant heterocycles is an important objective. Microwave-induced pyrrole synthesis has become an environmentally benign route in organic transformation with reduced reaction time and high yields. This mini-review focuses on the eco-friendly microwaveinduced synthesis of pyrroles, their derivatives, and their potential pharmacological applications, covering literature up to 2022.