Current Organic Chemistry - Volume 27, Issue 13, 2023

In this work, the potential of supported ionic liquids-based biocatalysts was presented. Efforts are underway to identify suitable carrier matrices for biocatalytic reactions, considering the crucial role of surface morphology. Factors such as mechanical and thermal properties, surface area, pore volume, density, and functionalization potential are being carefully considered during selection. The correlation between carrier, enzym Read More

1,4-dithian-2,5-dihydroxyl is the major source for the synthesis of sulfur-containing heterocyclic compounds such as thiophene and 1,3-thiazole derivatives, which these compounds are widely used in pharmaceuticals and agricultural industries. Sulfur-containing heterocycles, such as 2-aminothiophene, thiazolidine, oxothiazolidine, and thiazoles, can be comprehensively synthesized from dimerization of the derivatives of Read More

Fenamic acid-derived NSAIDs contain N-phenyl anthranilic acid as a pharmacophore with pKa ∼ 4, which is completely ionized at the physiological pH and is mainly excreted in the urine by hydroxylation or glucuronidation. The acid (-COOH) functionality in fenamic acid provides a template for their fenamate derivatization for the development of analogues based on amidation, esterification, and etherification. Besides the repur Read More

Owing to its momentous significance in the development of new medications, phenazine, and its analogues are successful heterocyclic scaffolds as well as essential building blocks for developing physiologically active chemicals. Traditionally, phenazine and its derivatives have been synthesized using chemical methods that involve toxic organic solvents, dangerous reagents, and the risk of hazardous metal contamination in the fi Read More

Poly(amidoamine) (PAMAM) is easily prepared with ethylenediamine as the precursor to form a dendritic structure with a size of 1.4 -11.4 nm from generation 1 to 10. The terminal amino groups of PAMAM could be grafted active species, such as 1,8-naphthalimide (NI) or its derivatives, to integrate their photophysical properties into PAMAM as NI-PAMAM. With/without metals, the new dendritic platforms can be found for dif Read More

Artemisia vulgaris is used to treat rheumatism, scabies, and trauma-related pain in traditional Vietnamese medicine. However, there is a lack of in vitro and in silico studies on the antibacterial and anti-inflammatory effects of Artemisia vulgaris in Vietnam. This research was designed to evaluate the bioactivities of extracts and isolated flavonoids from this plant. The results indicated that crude extract (AVE) and sub-fracti Read More

New methods have been developed for the synthesis of the third representative of the homologous series of diamond-like hydrocarbons, triamantane, with a yield of up to 78%, by skeletal isomerization of iso-compositional endo-endo- and exo-exo-heptacyclo [9.6.1.02,10.03,8.04,6.05,9.012,17]octadecanes under the action of aluminate ionic liquids. For the first time, the synthesis and transfor Read More