Current Organic Chemistry - Volume 27, Issue 2, 2023

This review updates the field of asymmetric cascade palladium catalysis applied to the synthesis of chiral heterocycles since 2019. It illustrates how much a diversity of chiral palladium catalysts promote unprecedented asymmetric domino reactions of many types, allowing direct access to a wide variety of complex and densely functionalized chiral heterocyclic molecules.

One of the most widely utilized hypervalent iodines used as an oxidizing agent in organic chemistry is (dialcetoxyiodo)benzene (PhI(OAc)2), also known as (DAIB), phenyliodine(III) diacetate (PIDA). In this mini-review, PIDA is highlighted in relation to its applications in organic synthesis involving rearrangement/migration reactions along with their interesting mechanistic aspects from the summer of 2015 to the present.

The exploration of synthetic methodologies that allow rapid access to a wide variety of N-heterocycles is of critical importance to the medicinal chemist as it provides the ability to expand the available drug-like chemical space and drives more efficient drug discovery programs. β-Nitrostyrenes, as unique active intermediates, have been widely applied in synthetic organic chemistry because of their versatile utility a Read More

Among all the heterocyclic scaffolds, 1,4-dihydropyridine (1,4-DHPs) is an important class of nitrogen-containing heterocyclic compounds possessing prominent therapeutic effects, which play an essential role in pharmaceutical chemistry. Multicomponent reactions (MCRs) have proven to be an invaluable tool for swiftly synthesizing large and structurally diverse molecules from simple starting materials. The chemists ha Read More

Ever since their discovery, Ionic Liquids have raised great interest in organic transformations ranging from solvents to catalytic entities. These belong to a class of nonmolecular compounds composed of ions having curiously low melting points. In the last few years, the Supported Ionic Liquids have drawn the attention of researchers and chemists due to their advantages over homogeneous catalysis. The most commonl Read More