Current Organic Chemistry - Volume 27, Issue 4, 2023

Concerned about a million people are infected worldwide, and other millions are living at risk zones of infection. Chagas disease causes 10 000 deaths annually, and the discovery of safe and effective drugs on a nanomolar scale has been headlined as a crucial goal by the worldwide research community and international health agencies. Nifurtimox and Benznidazole are the only marketed drugs for Chagas disease th Read More

Immobilized lipase has played an essential role in the chemical and biological sciences as a viable alternative to standard chemical catalysts. Glutaraldehyde is a low-cost crosslinking agent at risk of being superseded by developing crosslinking compounds with biocompatible, biodegradable, and non-toxic characteristics. The multipoint covalent treatment method using glutaraldehyde has both advantages and Read More

The current review focused on the various methods for synthesizing pyrido[2,3- d]pyrimidine derivatives and the reactions of pyrido[2,3-d]pyrimidine derivatives with important pharmaceutical and biological activities.

1,4-benzodiazepines play a valuable role in organic and medicinal chemistry. In this review article, we have mainly discussed the synthesis of various 1,4-benzodiazepines in the presence of a palladium catalyst. Different reactions, such as intramolecular N-arylation, reductive elimination, oxidative addition, intramolecular alkylation, C-H activation, aryl-aryl bond formation, etc., are included. For these types of syntheses, an Read More

Click reactions have gained enormous popularity among chemists for their ambient reaction parameters and wide application in various frontier research fields. Photo-initiated click reactions add another dimension of spatiotemporal control which ensures fruitful bioorthogonal reaction. Several cycloaddition reactions, enlisted in the category of ‘photo click’ reactions due to the fast kinetics and ambient reaction condition Read More

Aurones, a member of the flavonoid family, have limited occurrence in nature and are relatively less explored than other flavonoids but still constitute a gleaming class of therapeutically significant oxygen heterocyclic molecules with broad-spectrum biological activities. These are secondary plant metabolites and are responsible for glaring pigmentation to various colored parts of the plants. This review covers the c Read More

Organic light emitting diode (OLED) is a device that uses organic semiconductor materials to emit light under the action of an electric field. Compared with traditional luminescent materials, they have the advantages of good softness, low-temperature resistance, wider field of vision and low energy consumption, and have been widely used in the field of display and lighting in recent years. In addition, compared with red a Read More

Anthracyclines are one of the most effective cancer treatments ever created, but these compounds are somewhat cardiotoxic to some patients, causing heart failure. The likelihood of such adverse effects restricts the overall prescribed dose of anthracyclines for patients. Based on the pathophysiology of anthracycline-induced cardiotoxicity, the cardiotoxicity plausibly originates from a reduction reaction of a single elect Read More