Current Organic Chemistry - Volume 27, Issue 10, 2023

The transition metal-catalyzed C-C and C-X (X=heteroatom) homo and crosscoupling reactions were pioneered as a momentous strategy for the total synthesis of natural products, agrochemicals, pharmaceuticals, etc. Among the various transition metal-catalyzed reactions, manganese catalysis held a distinctive identity owing to its earth-abundance and eco-friendliness apart from its unique characteristics. Despite havin Read More

Pyridazine derivatives are an important heterocyclic family in medication development. Because of their biological relevance, there has been a surge in interest in the chemistry of pyridazine derivatives in recent years. Anti-tubercular, antifungal, antibacterial, analgesic, anti-inflammatory, antihypertensive, anticancer, antidiabetic, anti-AIDS, cardiovascular activity, anticonvulsant, and possibly useful neuroprotective actions Read More

Cancer is becoming more common worldwide, impacting the vast majority of people. As a result, new anticancer drugs are currently being created, and their safety is still being assessed. Pyrazine-based medications are a substantial contribution, as they are one of the most important pharmacophores found in heterocyclic compounds both synthetically and naturally. It's a six-membered aromatic heterocycle with two n Read More

combination of cancer therapy (hyperthermia with other therapies) holds tremendous potential for therapeutic improvement. Conventional methods of inducing hyperthermia are incapable of limiting a high-temperature increase at the tumor location while also preserving unexposed healthy tissues. Different materials available are not suitable for the combined application of hyperthermia and photothermal therapy (P Read More

5-Amino-4-formyl pyrazole 1 was used as a precursor for the synthesis of 6- aminopyrazolo[3,4-b]pyridine-5-carbonitrile 2, and 6-aminopyrazolo[3,4-b]pyridine-5- carboxamides 3 and 4. Pyrazolo[3,4-bpyridines 2, 3, and 4 were treated with different reagents leading to structurally confirmed heterocycles. Mosquito adult females carry and transmit the causatives of many diseases to humans and other d Read More

A series of new diethyl 4,6-diarylpyridin-2-yl phosphonate derivatives 3a-f, and 5a,b were synthesized, in good yields, from the reaction of 2-bromo-4,6-diarylpyridines 1a,b with Wittig-Horner reagents 2a-c, and 4 in DMF containing sodium hydride at reflux temperature. The newly synthesized compounds were evaluated for antimicrobial and antioxidant activity. The results demonstrated that compounds 5a and 5b exhibited str Read More

The use of organophosphorus (OP) Nerve Agents (NAs) as chemical weapons still represents a real danger for the safety of population threaten by conflicts or terrorist attacks. A fast and easy-to-use detection of this hazardous gases could make the difference in emergency state. Specifically, the possibility to develop a detection system involving an easily accessible tool, such as a smartphone, is the driving force of the current Read More

The pursuit of biologically active compounds has led many researchers to synthesize different heterocyclic hybrids with prominent activity. Both coumarin and 1,2,4-triazole are very potent scaffolds whose hybrids have improved biological activities. This study synthesized twenty-one new coumarin-1,2,4-triazole hybrids in a one-step reaction using choline chloride : urea deep eutectic solvent. The green approach to this sy Read More