Current Organic Chemistry - Volume 27, Issue 17, 2023

A heterocyclic scaffold-like benzodiazepine (BZD) has shown a wide variety of medicinal values and utmost importance in pharmaceutical industries. BZDs are sevenmembered heterocyclic molecules and have many structural isomers, such as 1,2; 1,3; 1,4; 1,5; 2,4; and 2,3. Among these BZDs, 1,5-BZDs play a significant role in pharmacological activities like anti-anxiety, anti-convulsion, antimicrobial, sedative, and h Read More

This review describes recent advances that are commonly applied in the synthesis of dialkyl (aryl) α-aminophosphonates containing heterocyclic compounds. The target structures are divided into three categories, which include α-aminophosphonic acids and their diesters bearing a heterocyclic or heteroaryl system at the α-carbon, nitrogen atom, or both. The synthetic protocols based on the Kabachnik-Fields and P Read More

Dess-Martin periodinane (DMP) is one of the hypervalent iodines that is most frequently utilized as an oxidizing agent in organic chemistry. The authors of this septennial review have critically and methodically presented representative applications of DMP in organic synthesis from 2015 to the present, including oxidations, dehydrogenations, hetero and homo-dimerizations, aromatizations, thiocyanations, halogenations, dea Read More

The Annona muricata L. leaves have been long employed in the traditional remedy of diabetes mellitus (DM) and its comorbidities. Different analytical techniques were used to evaluate the methanol extract of this plant part. In vitro antidiabetic assays of A. muricata extract were analysed using α-glucosidase and α-amylase inhibition tests. Employing gas chromatography-mass spectrometry (GC-MS), the primary b Read More

Tetrahydrobenzo[b]pyrans are fused oxygen-containing heterocycles that are found in many biologically active compounds. Therefore, researchers in organic synthesis are searching for suitable, efficient, and useful methods for their synthesis. In this contribution, a series of tetrahydrobenzo[b]pyran derivatives was synthesized using aryl aldehydes, malononitrile, and cyclohexane-1,3-dione or dimedone as th Read More

A total of eleven ortho-carboxamidostilbene derivatives were synthesized through Heck coupling with a different type of amide derivatives. These compounds were characterized by FTIR, 1D- and 2D-NMR as well as mass spectroscopy analysis (HRESIMS). The synthesized compounds were tested for their cytotoxic potential against four human cancer cell lines (MCF-7, MDA-MB-231, MCF-7/TAMR-1, and A549), as well as two Read More