Current Nanomedicine - Online First

Background The goal of the current study was to create Azithromycin-loaded niosomes and conduct in vitro evaluation for topical eczema management. Eczema is a common dry skin disorder that causes inflammation and may affect people of any age, mainly in early infancy ages. Another term for dermatitis is “Derma” which refers to skin, and “dermatitis” “Tis” refers to inflammation. Both phrases are interchang Read More

Background The biosynthesis of nanoparticles of copper oxide nanoparticles via using plant extracts and phytochemicals has garnered significant interest due to their potential medical applications. This study focuses on synthesizing CuONPs using Rubus ellipticus leaf extract (CuONPs-Re) as an efficient reducing agent. Methods The CuONPs-Re were characterized using various techniques: UV-Visible Spectroscopy Observed a pea Read More

Although garlic oil is well known for its medicinal benefits, its low solubility and lipophilic characteristics result in restricted bioavailability. The goal of this work was to create a stable nanoemulsion technology that would increase the anti-inflammatory properties of garlic oil. Particle size, stability, zeta potential, and polydispersity index were used to characterize the nanoemulsion. in vitro and in vivo models were used to assess the Read More

Ocular diseases such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy are leading causes of vision impairment and blindness globally. Despite advancements in treatment, these conditions remain challenging due to the eye's unique anatomical and physiological barriers. The corneal barrier, tear dynamics, and rapid ocular clearance mechanisms, such as lacrimation and blinking, greatly limit the Read More

Background Ocimum gratissimum has folklorically been ascribed to possess several medicinal activities, including antimalarial. Objective This research explored the antimalarial activity in its essential oil and the anti-anaemic effect of Hibiscus sabdariffa (Hs) in combination. Methods Ocimum gratissimum essential oil (OGE) was extracted through hydro distillation and analyzed using GC/MS. Hs extract was obtained usi Read More

Introduction Based on the scientific evaluation from the literature survey, polyphenolic compounds have numerous health benefits but limitations such as poor bioavailability, making it difficult for the formulator. Polyphenolic compounds face major challenges such as poor solubility, stability, and lesser absorption in the body. It is the major concern towards the bioactives for formulating it into suitable delivery and also for spec Read More

Metallic nanoparticles, specifically silver nanoparticles, find huge applications in health, medicine, and drug delivery. However, the physical and chemical synthesis methods pose challenges regarding gener, action of toxic by-products, or high energy requirements. Hence biosynthetic approaches have gained interest in the last few years utilizing various sources including yeast, fungi, bacteria, or plant extracts containi Read More

Transdermal drug delivery systems have greatly attracted investigators because of their advantages over parenteral and oral delivery methods. The skin's structure usually limits drug penetration, prompting the development of vesicular transdermal drug delivery systems like ethosomes, liposomes, niosomes, transferosomes, etc., to increase drug delivery. This review aims to explore the concept of transferosome and to c Read More

Cisplatin, also known as cis-(diammine) dichloridoplatinum (II) or CDDP, is frequently used as first-line chemotherapy in head, neck, and lung malignancies. It can be given as a single agent or in conjunction with radiation therapy and/or other anti-cancer chemotherapeutic agents. Now, experiences based on PEGylated liposome-based nano-formulations AroplatinTM, LipoplatinTM, and SPI-077 are undergoing clinical trials Read More