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Nanoformulations are a novel method of administration of the drug, approved by the USFDA. These formulations are able to deliver the drug molecules to the target site more effectively and efficiently. So, this technology has found a vital role in cancer therapy. The nanoformulations can be of many types: Liposomes, Micelles, Nano-emulsions, Dendrimers, etc. Many studies have been done on nanoformulations and it is revealed that a number of natural products like curcumin, thymoquinone and papaverine, which contain anti-cancer activity, are more effective in nanoformulation form. This review discusses the nanoformulations, their applications, uses and advantages in cancer therapy along with the anti-cancer drugs that are administered as nanoformulations.