Organic Chemistry
Targeting the Receptor Complexes by Structure-based Natural Drug Compounds in Seizures: A New Dimension in Drug Discovery and Design
May 2025
Article
Source:
Natural Products Journal, The
15,
E040624230683
(2025)
A seizure is the brain's uncontrolled abnormal electrical activity which may result in altered states of consciousness behavior memory or emotion. Seizures start biologically with the activation of susceptible brain neurons which causes synchronized discharges of larger groups of connected neurons. A few potential causes of seizures include medications genetics electrolyte abnormalities sleep state infections brain inflammation and injuries. Medicina Read More
Effect of Herbal Medicine on Insulin Signaling Pathways and Insulin Resistance in Metabolic Dysfunction-associated Fatty Liver Disease: A Review
May 2025
Article
Source:
Natural Products Journal, The
15,
E040624230641
(2025)
IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease progressing towards a substantial global health concern. A multitude of therapeutic agents are being used to treat MAFLD. The high prevalence and adverse effects of drugs have increased the global popularity of herbal medicines (HMs) as effective therapeutic agents to treat MAFLD. Among the causes of pathogenesis insulin resistance (I Read More
Research Progress in Natural Products against Liver Fibrosis
May 2025
Article
Source:
Natural Products Journal, The
15,
E040624230657
(2025)
Fibrosis of the liver is the most common pathological feature of many chronic liver diseases progressing to cirrhosis and eventually liver cancer. Currently only individual genes or proteins are targeted by synthetic drugs used to treat liver fibrosis they have limited therapeutic effect and are associated with many side effects. In contrast natural products have shown great advantages and potential in the treatment of liver fibrosis due to their structural divers Read More
Comparative Analysis and Characteristic Verification of the Quality Standard of Milk Thistle Extract
May 2025
Article
Source:
Natural Products Journal, The
15,
E180724231996
(2025)
IntroductionMilk thistle extract is widely used in dietary supplements due to its strong hepatoprotective effect. There are some differences in the quality characteristics and standard values of milk thistle extract set by pharmacopoeias and standards in various countries and regions.MethodsTo promote the standardization of quality standards for milk thistle extract this paper summarized and compared the standard characteristics and related values s Read More
Novel Approaches for the Extraction and Identification of Phytoconstituents from Herbs and Spices
May 2025
Article
Source:
Natural Products Journal, The
15,
E060624230784
(2025)
An important determinant of population health is the caliber and quality of food that can directly affect the health of the population. Herbs and spices are now the primary ingredients in the global food and nutraceutical industry. Traditional methods for extraction of active metabolites of herbs and spices may lead to lowered extraction efficiency due to high solvent consumption and a longer extraction period. These issues can be resolved by the use of n Read More
Systematic Detoxification of Copper-induced Toxicity by Methanolic Extracts of Anacyclus pyrethrum (L) in Zebrafish Model
May 2025
Article
Source:
Natural Products Journal, The
15,
E120624230976
(2025)
IntroductionAnacyclus pyrethrum is used in Ayurveda to treat various ailments ranging from toothache to female infertility. However the molecular mechanisms of its medicinal properties are obscure and need exploratory studies.MethodsWe aimed to investigate the molecular mechanisms associated with the medicinal properties of A. pyrethrum using zebrafish as an in vivo model. We have employed in silico in vitro and in vivo approaches to el Read More
Potential Herbal Therapy in Dermatology: A Review of Malaysian Medicinal Plants
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060624230786
(2025)
Dermatology is a medical aspect that revolves around the diseases of the skin. The incorporation of medicinal plants in the treatment of skin diseases has been widely used since ancient days. Malaysia is blessed with various plant species and rich biodiversity with tropical weather year-round. With the emerging use of medicinal plants in dermatology more studies on their potential therapeutic effects need to be reviewed thoroughly. Thus the purpose of thi Read More
Add-on Therapy with Melatonin in the Acute Bipolar Mania Treatment: Results of a Randomized, Placebo-controlled Trial
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060624230788
(2025)
Background and ObjectivePrior research indicates that disruptions in melatonin secretion levels and timing could be linked to the pathophysiology of bipolar disorder. Our study aimed to assess the effectiveness of melatonin as an adjunctive therapy to classical mood stabilizers in addressing sleep impairment and mood symptoms in bipolar patients currently experiencing manic episodes.MethodsFifty-eight hospitalized patients with a mean age of 38.04 ± 11 Read More
A Systemic Review of Pre-clinical Studies of Herbal Plants having Anti-Polycystic Ovarian Syndrome Activity: A PAN-India Study
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E160524230026
(2025)
BackgroundPolycystic ovarian syndrome (PCOS) is a prevalent endocrine and metabolic condition seen in premenopausal women. A number of pharmacological agents like metformin oral contraceptives and anti-androgen agents have been used to treat PCOS and its associated implications but it has been associated with numerous negative effects like fatal and nonfatal lactic acidosis weight gain cardiovascular and hepatic toxicity.Methodology Read More
Cytotoxic Secondary Metabolites from the Ascomycetous Fungus Pseudogymnoascus roseus
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060524229697
(2025)
BackgroundFungi found in unique and competitive environments are abundant in bioactive compounds.ObjectiveThe objective of this study is to isolate and identify secondary metabolites from fungi of unique ecological niches and evaluate their cytotoxicity.MethodsThe compounds were isolated and purified using silica gel column chromatography Sephadex LH-20 gel chromatography and semi-preparative high-performance liquid chromatography (HPLC). T Read More
Role of Polyphenols to Attenuate Depressive Disorders and Cognitive Impairments Associated with Diabetes Mellitus – A Comprehensive Review
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060624230792
(2025)
Diabetes Mellitus and its associated brain disorders become more prevalent across the globe. Several comorbidity factors are associated with diabetic mellitus as well as the nervous system. Static molecular variations in the Central Nervous System (CNS) due to Hyperglycemia may be a major cause of psychiatric disorders. Carbohydrates and proteins imbalance as metabolic parameters impact the downregulation of neurotransmitters in the brai Read More
A Systematic Review on the Evolution of Natural Mutation-dependent Antiviral Drug Resistance in Hepatitis C Virus (HCV) Genotypes Prevalent in Saudi Arabia: A Genomic and Therapeutic Perspective
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E030424228571
(2025)
BackgroundThe characterization of resistance-associated amino acid substitution (RAAS) in direct-acting antivirals (DAA) molecular targets could reshape the treatment strategy for HCV infection. Hence this review aimed to provide evidence on the impact of the RAASs on DAA treatment for HCV.MethodsPRISMA model was followed for the literature survey and evaluation (sources: PubMed Sci-Hub and Google Scholar). RAASs in DAA target proteins and thei Read More
Revolutionizing Plant Tissue Culture: Harnessing Artificial Intelligence for Precision Propagation and Optimization
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E040624230642
(2025)
Plant tissue culture is a process of in vitro regeneration requiring numerous resources and intensive labour to mass produce disease-free clones. Diverse factors such as sterilizing agents media composition and environmental conditions contribute toward successful regeneration and decide the production such as the total shoot number shoot length in vitro rooting and adaptation of plants to the external environment. Plant tissue culture the successful ind Read More
A Comprehensive Review of n-butylidenephthalide: The Potential Therapeutic Effect and Possibility for Targeted Therapy
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060624230782
(2025)
n-Butylidene phthalide (N-BP) is a natural derivative obtained from the chloroform extract of Angelica Sinensis. In conventional medicine it treats different ailments. Various pharmacological properties are associated with it including anticancer anti-inflammatory and neuroprotective properties. Based on its reported pharmacokinetic profile n-BP has low oral bioavailability and is rapidly absorbed and eliminated from the body. The compound has divers Read More
Advancements in Chemical Proteomics for Target Identification of Natural Products in Live Cells
Apr 2025
Article
Source:
Natural Products Journal, The
15,
E060624230779
(2025)
Natural products have evolved to interact with specific protein targets within cells making them valuable for various biological functions. Chemical proteomics specifically the use of covalently linked probes in live cells allows for the identification of protein-binding partners or targets of small molecules. Recent advancements in target identification of natural products have utilized affinity-based probes and photo-affinity labeling techniques enabling the ca Read More
A New Route for the Synthesis of Trichloromethyl-1H-Benzo[d]imidazole and (1,2,3-Triazol)-1H-Benzo[d]imidazole Derivatives via Copper-catalyzed N-Arylation and Huisgen Reactions
Apr 2025
Article
Source:
Current Organic Chemistry
29,
pp 591
- 598
(2025)
In this study functionalized 2-(trichloromethyl)-1H-benzo[d]imidazole derivative with good yields was synthesized using a copper-catalyzed N-arylation reaction of 2-iodoaniline and trichloroacetonitrile. This reaction was performed by employing the catalytic value of copper (I) and 110-phenanthroline as the ligand in tetrahydrofuran solvent at 23°C. In the following the reaction of the final product with phenylacetylene and sodium azide (Huisgen reacti Read More
Ultrasound-assisted Synthesis of Novel 4-[3-acetyl-2-(N-alkyl(aryl)acetamido)-1,3, 4-thiadiazol-5-yl]-3-(2-oxo-2H-chromen-3-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazoles: Anticancer Activities, Apoptotic, Cell Cycle, Molecular Docking, and ADMET Studies
Apr 2025
Article
Source:
Current Organic Chemistry
29,
pp 569
- 579
(2025)
A novel series of 4-[3-acetyl-2-(N-alkyl(aryl)acetamido)-134-thiadiazol-5-yl]-3-(2-oxo-2H-chromen-3-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazoles (2a-i) and 3 was synthesized in good yields. The methodology was depended on a one-pot four-components reaction of hydrazine hydrate alkyl(aryl) isothiocyanate 3-(2-oxo-2H-chromen-3-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazole-4-carboxaldehyde (1) and acetic anhydride in acetic acid under ultrasound irradiation. The Read More
Exploring the Potential of Novel 4-thiazolidinone Derivatives as Dual Anti-inflammatory and Antioxidant Agents: Synthesis, Pharmacological Activity and Docking Analysis
Apr 2025
Article
Source:
Current Organic Chemistry
29,
pp 580
- 590
(2025)
A series of 4-thiazolidinone was synthesized and characterized by means of TLC melting point and spectral data like IR 1H NMR and Mass spectra. The anti-inflammatory activity of the synthesized compounds was determined via in vivo studies. The antioxidant properties of the synthesized compounds were determined by carrageenan-induced rat paw edema model. The synthesized compounds (A1-A14) showed significant anti-inflammatory and antio Read More
An Insight into Ethanopharmacology, Phytochemistry, and Pharmacological Properties of Genus Andrographis
Apr 2025
Article
Source:
Current Organic Chemistry
29,
pp 519
- 568
(2025)
Andrographis is a member of the family Acantheceae. It contains approximately 44 accepted species. Among them Andrographis paniculata has been extensively studied during the last decade. The genus contains triterpenoids as the main class of compound along with carotenoids flavonoids glycosides xanthones phenolic compounds and fatty acid compounds. A. paniculata has been reported in Ayurveda homeopathy naturopathy and Siddha. Tra Read More
1-Thiosugars: From Synthesis to Applications
Mar 2025
Article
Source:
Current Organic Chemistry
29,
pp 359
- 401
(2025)
1-Thiosugars and their glycosides play crucial roles in carbohydrate chemistry primarily due to their stability and potential for mimicking O-glycosides. The synthetic methodologies for thioglycosides pose ongoing challenges. In recent years researchers have shown a growing interest in exploring the applications of thiosugars in various fields including the development of natural product derivatives oligo- and polysaccharide mimics metallodrugs and dendri Read More
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