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Volume 15, Issue 5
  • ISSN: 2210-3155
  • E-ISSN: 2210-3163

Abstract

Introduction

Harnessing the bioactive compounds from seaweed for inflammatory diseases holds great promise for developing new and effective treatments that are natural, sustainable, and potentially free from the side effects commonly associated with synthetic drugs.

Methods

The objective of this study was to examine the phytochemical levels, as well as the antioxidant and anti-inflammatory properties of the edible red seaweed . The methanol extract of the seaweed showed potent radical scavenging activity. Analysis using GC-MS techniques identified two distinct phytochemical compounds in extract, namely 1,1-dipropylhydrazine and 4-chlorobuten-3-yne.

Results

When tested on copper-induced zebrafish embryos, the extract reversed the upregulation of MMP9 and NFκBp65, as evidenced by western blotting and zymography methods.

Conclusion

These findings suggest that the bioactive compounds found in extract could be utilized for the development of natural sources for antiradicals, food supplements, nutraceuticals, and various functional foods with therapeutic applications.

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2024-06-04
2025-03-30

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/content/journals/npj/10.2174/0122103155294834240607054701
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Investigating the Therapeutic Potential of Gracilaria edulis Extract in Copper-exposed Zebrafish Embryos: An Anti-inflammatory Perspective
Natural Products Journal, The 15, E22103155294834 (2025); https://doi.org/10.2174/0122103155294834240607054701
/content/journals/npj/10.2174/0122103155294834240607054701
/content/journals/npj/10.2174/0122103155294834240607054701
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  • Article Type:     Research Article
Keyword(s): CuSO4 induction; Gracilaria edulis; Inflammation; MMP 9; NFκB; Zebrafish embryos

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