Current Pharmaceutical Design - Online First

Benzothiazole derivatives have garnered considerable attention owing to their versatile chemical scaffold and remarkable biological activities. The article provides an in-depth analysis of the diverse structural modifications and strategies employed to enhance the anticancer potential of these compounds from the period of 2020 to 2024. It discusses the role of structure-activity relationships (SAR) and computational approache Read More

Background Zuo Gui pill (ZGP) is a herbal compound formulation used to treat knee osteoarthritis (KOA), but its underlying mechanisms are still unclear. This study aimed to initially elucidate the molecular mechanisms of ZGP in treating KOA using network pharmacology and molecular docking techniques. Methods We collected information on the drug compounds and targets from TCMSP, HERB, BATMAN-TCM, and UniPr Read More

Liver cancer, particularly Hepatocellular Carcinoma (HCC), remains a significant global health challenge owing to its high incidence and position as the fourth leading cause of cancer-related mortality. HCC represents 75-85% of all liver cancer cases and ranks as the sixth most prevalent cancer globally. Several factors, including late-stage diagnosis, limited treatment effectiveness, resistance to conventional therapies, and adver Read More

Novel vaccine formulations called nano vaccines which use nanoparticles (NPs) as adjuvants or carriers, are being developed in place of conventional vaccines. The field of study on peptide-based nano vaccines is enlarging fast as a result of combining antigenic peptides with nano-transport systems. This paper explores advancements in anticancer nano vaccines, focusing on their mechanisms, challenges, and oppo Read More

Introduction Eprosartan is an effective blood pressure medication that blocks the Angiotensin Type 1 (AT1) receptor. The studies conducted on Eprosartan showed anti-oxidative stress effects and modulating inflammatory mechanisms. The current research is designed to clarify and examine the possible advantageous impacts of Eprosartan against chronic ethanol-induced hepatic damage. Method Twenty-four male Read More

Background Healthcare is rapidly leveraging machine learning to enhance patient care, streamline operations, and address complex medical issues. Though ethical issues, model efficiency, and algorithmic bias exist, the COVID-19 pandemic highlighted its usefulness in disease outbreak prediction and treatment optimization. Aim This article aims to discuss machine learning applications, benefits, and the ethical and pract Read More

Parkinson's Disease (PD) is a neurodegenerative disorder of the central nervous system (CNS). Given the increasing age of the general population, PD has emerged as a significant public health and societal concern, impacting both individual well-being and socioeconomic progress. The present interventions have proven insufficient in impeding the progressive nature of PD. Consequently, it is imperative to promptly identify effica Read More

Long non-coding RNAs (lncRNAs) are a type of RNA with a length of more than 200 nucleotides. They do not encode proteins but are crucial in regulating gene expression and affecting the malignant biological behavior of cancer. Small nucleolar RNA host gene 10 (SNHG10) is a novel lncRNA that plays a regulatory role in many malignant tumors. Several recent studies have shown that SNHG10 is aberrantly expressed in vario Read More

Aim Quercetin, a bioactive flavonoid extracted from traditional Chinese medicine, has anti-hepatocellular carcinoma effects. Farnesoid X receptor (FXR), a nuclear receptor highly expressed in the liver, plays important roles in maintaining hepatic glucose homeostasis, anti-inflammation, liver regeneration, and anti-cancer properties. Whether quercetin regulates the glycolysis/glycolysis pathway through FXR signaling remains Read More