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image of Synthesis and Characterization of Zn(1-x-y)MnxCoyO NPs for Liver Cancer Treatment

Abstract

Introduction

In this study, pure and cobalt manganese-doped ZnO nanoparticles (ZnMnCoO NPs) at varying concentrations were synthesized through sol-gel method, and zinc acetate dihydrate, 
manganese nitrate, cobalt acetate, and diethyl amine were used as precursors, with samples finally calcined at 700oC.

Method

The hexagonal wurtzite structure of pure and co-doped ZnO NPs was confirmed by X-ray diffraction (XRD). The computed grain sizes of pure and co-doped ZnO NPs, according to Scherrer's formula, were 32 nm, 32.5 nm, 36.3 nm, and 36.5 nm, respectively. SEM was used to observe the morphology of nanoparticles. FTIR spectroscopy was used to examine the chemical make-up and vibrational modes of pure and co-doped ZnO NPs. The bandgaps of pure and doped ZnO were examined using UV-Vis spectroscopy.

Results

It was found that the optical bandgap of ZnO was lowered by 3.21 eV by manganese and cobalt doping. Elemental composition analysis was performed by using EDX analysis. Finally, anticancer activity of pure and co-doped ZnO NPs was assessed by employing MTT assay, which indicated that Zn Mn CoO NPs showed significant anticancer results against liver cancer (HepG-2) cells as compared to ZnO, Zn MnCoO and Zn Mn CoO NPs. Moreover, Zn Mn CoO NPs showed low toxicity and good biocompatibility comparable to doxorubicin (DOX).

Conclusion

Comprehensive experimental findings have demonstrated an authentic way of obtaining feasible liver cancer therapy.

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2025-02-26
2025-03-30

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/content/journals/cpd/10.2174/0113816128330548250206101727
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Synthesis and Characterization of Zn(1-x-y)MnxCoyO NPs for Liver Cancer Treatment
Bentham Science Publishers ; https://doi.org/10.2174/0113816128330548250206101727
/content/journals/cpd/10.2174/0113816128330548250206101727
/content/journals/cpd/10.2174/0113816128330548250206101727
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  • Article Type:     Research Article
Keywords: cancer treatment ; sol-gel method ; MTT assay ; liver cancer cell line ; Co-doped ZnO NPs

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