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image of Vegetable Oils in Skin Whitening - A Narrative Review

Abstract

Plants are a source of a variety of compounds, such as vegetable oils, which are rich in fatty acids and possess skin-whitening properties. Considering the hyperpigmentation treatment challenges (lack of efficacy or aggressiveness), the constant search for new whitening substances is necessary. Given vegetable oils’ potential and application in dermatological and cosmetic products, we reviewed the scientific literature on vegetable oils with skin depigmenting activity. It was observed that a variety of species (, , , , , , , , , , , , , , , , , , , Taiwanese species Taichung selective No. 4 (TCS4) (Adlay bran), ) were evaluated regarding their skin whitening properties. All the studies demonstrated that the oils have skin whitening properties and that the oils’ activity is related to their composition. The harvesting period, as well as the extraction method, impact on the oils’ properties, hence in their activity. The use of vegetable oils can have advantages over an isolated compound as their components can have synergistic or adding effects. When conducting skin whitening experiments, it is recommended to employ multiple assays because vegetable oils can influence skin whitening through various mechanisms. Furthermore, more clinical trials should be encouraged, considering the potential of vegetable oils as skin-lightening ingredients. More innovative and effective formulations can be obtained using vegetable oils for skin whitening purposes.

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2025-03-17
2025-03-30

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References

  1. Kunik O. Saribekova D. Lazzara G. Cavallaro G. Emulsions based on fatty acid from vegetable oils for cosmetics. Ind. Crops Prod. 2022 189 115776 10.1016/j.indcrop.2022.115776
    [Google Scholar]
  2. Ferraz C.A. Pastorinho M.R. Palmeira-de-Oliveira A. Sousa A.C.A. Ecotoxicity of plant extracts and essential oils: A review. Environ. Pollut. 2022 292 Pt B 118319 10.1016/j.envpol.2021.118319 34656680
    [Google Scholar]
  3. Huerth K.A. Hassan S. Callender V.D. Therapeutic insights in melasma and hyperpigmentation management. J. Drugs Dermatol. 2019 18 8 718 729 31424704
    [Google Scholar]
  4. Contri R.V. Fiel L.A. Pohlmann A.R. Guterres S.S. Beck R.C.R. Transport of substances and nanoparticles across the skin and in vitro models to evaluate skin permeation and/or penetration. Nanocosmetics and Nanomedicines: New Approaches for Skin Care. Beck R. Guterres S. Pohlmann A. Berlin, Heidelberg Springer Berlin Heidelberg 2011 3 36 10.1007/978‑3‑642‑19792‑5_1
    [Google Scholar]
  5. Ruiz Ruiz J.C. Ortiz Vazquez E.D.L.L. Segura Campos M.R. Encapsulation of vegetable oils as source of omega-3 fatty acids for enriched functional foods. Crit. Rev. Food Sci. Nutr. 2017 57 7 1423 1434 10.1080/10408398.2014.1002906 26114760
    [Google Scholar]
  6. Zeitoun H. Michael-Jubeli R. El Khoury R. Baillet-Guffroy A. Tfayli A. Salameh D. Lteif R. Skin lightening effect of natural extracts coming from Senegal botanical biodiversity. Int. J. Dermatol. 2020 59 2 178 183 10.1111/ijd.14699 31681985
    [Google Scholar]
  7. Nde D. Foncha A. Optimization methods for the extraction of vegetable oils: A Rleview. Processes 2020 8 2 209 10.3390/pr8020209
    [Google Scholar]
  8. Parnsamut N. Kanlayavattanakul M. Lourith N. Development and efficacy assessments of tea seed oil makeup remover. Ann. Pharm. Fr. 2017 75 3 189 195 10.1016/j.pharma.2016.11.001 27988044
    [Google Scholar]
  9. Athar M. Nasir S.M. Taxonomic perspective of plant species yielding vegetable oils used in cosmetics and skin care products. Afr. J. Biotechnol. 2005 4 1
    [Google Scholar]
  10. Parvez S. Kang M. Chung H.S. Cho C. Hong M.C. Shin M.K. Bae H. Survey and mechanism of skin depigmenting and lightening agents. Phytother. Res. 2006 20 11 921 934 10.1002/ptr.1954 16841367
    [Google Scholar]
  11. Hushcha Y. Blo I. Oton-Gonzalez L. Mauro G.D. Martini F. Tognon M. Mattei M.D. microRNAs in the regulation of melanogenesis. Int. J. Mol. Sci. 2021 22 11 6104 10.3390/ijms22116104 34198907
    [Google Scholar]
  12. Lin J.Y. Fisher D.E. Melanocyte biology and skin pigmentation. Nature 2007 445 7130 843 850 10.1038/nature05660 17314970
    [Google Scholar]
  13. Qian W. Liu W. Zhu D. Cao Y. Tang A. Gong G. Su H. Natural skin‑whitening compounds for the treatment of melanogenesis (Review). Exp. Ther. Med. 2020 20 1 173 185 10.3892/etm.2020.8687 32509007
    [Google Scholar]
  14. Masaki H. Role of antioxidants in the skin: Anti-aging effects. J. Dermatol. Sci. 2010 58 2 85 90 10.1016/j.jdermsci.2010.03.003 20399614
    [Google Scholar]
  15. Levy C. Khaled M. Fisher D.E. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol. Med. 2006 12 9 406 414 10.1016/j.molmed.2006.07.008 16899407
    [Google Scholar]
  16. Gu J. Zhang X. Song B. Zhou D. Niu Y. Cheng G. Zheng Y. Wang Y. Chemical composition of tobacco seed oils and their antioxidant, anti-inflammatory, and whitening activities. Molecules 2022 27 23 8516 10.3390/molecules27238516
    [Google Scholar]
  17. Villareal M.O. Kume S. Bourhim T. Bakhtaoui F.Z. Kashiwagi K. Han J. Gadhi C. Isoda H. Activation of MITF by argan oil leads to the inhibition of the tyrosinase and dopachrome tautomerase expressions in B16 murine melanoma cells. Evid. Based Complement. Alternat. Med. 2013 2013 1 9 10.1155/2013/340107 23935660
    [Google Scholar]
  18. Prommaban A. Kuanchoom R. Seepuan N. Chaiyana W. Evaluation of fatty acid compositions, antioxidant, and pharmacological activities of pumpkin (Cucurbita moschata) seed oil from aqueous enzymatic extraction. Plants 2021 10 8 1582 10.3390/plants10081582 34451628
    [Google Scholar]
  19. Saba E. Kim S.H. Lee Y.Y. Kim H.K. Roh S.S. Kwak Y.S. Park C.K. Kim S.D. Rhee M.H. Anti-melanogenic effects of korean red ginseng oil in an ultraviolet B-induced hairless mouse model. Molecules 2020 25 20 4755 10.3390/molecules25204755 33081281
    [Google Scholar]
  20. Ting Y. Hu Y.T. Hu J.Y. Chang W.C. Huang Q. Hsieh S.C. Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish. Food Sci. Nutr. 2019 7 10 3216 3223 10.1002/fsn3.1176 31660135
    [Google Scholar]
  21. Shin J.A. Sun M. Jeong J.M. Borage oil treated with immobilized lipase inhibits melanogenesis. Lipids 2020 55 6 649 659 10.1002/lipd.12266 33128473
    [Google Scholar]
  22. Koo J.H. Lee I. Yun S.K. Kim H.U. Park B.H. Park J.W. Saponified evening primrose oil reduces melanogenesis in B16 melanoma cells and reduces UV-induced skin pigmentation in humans. Lipids 2010 45 5 401 407 10.1007/s11745‑010‑3405‑4 20352496
    [Google Scholar]
  23. Quiles J. Cabrera M. Jones J. Tsapekos M. Caturla N. In vitro determination of the skin anti-aging potential of four-component plant-based ingredient. Molecules 2022 27 22 8101 10.3390/molecules27228101 36432202
    [Google Scholar]
  24. Zoio P. Ventura S. Leite M. Oliva A. Pigmented full-thickness human skin model based on a fibroblast-derived matrix for long-term studies. Tissue Eng. Part C Methods 2021 27 7 433 443 10.1089/ten.tec.2021.0069 34148380
    [Google Scholar]
  25. REGULATION (EC) No 1223/2009 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 30 November 2009 on Cosmetic Products. OJEU. 2009 396 59 209
    [Google Scholar]
  26. Mohammed G.F. Al-Dhubaibi M.S. Mohamed M.L. Genital whitening with topical Cyperus rotundus oil enhances sexuality and quality of life. J. Cosmet. Dermatol. 2022 21 10 4490 4502 10.1111/jocd.14918 35290702
    [Google Scholar]
  27. Zaid A.N. Al Ramahi R. Depigmentation and anti-aging treatment by natural molecules. Curr. Pharm. Des. 2019 25 20 2292 2312 10.2174/1381612825666190703153730 31269882
    [Google Scholar]
  28. Khavkin J. Ellis D.A.F. Aging skin: Histology, physiology, and pathology. Facial Plast. Surg. Clin. North Am. 2011 19 2 229 234 10.1016/j.fsc.2011.04.003 21763983
    [Google Scholar]
  29. Zilles J.C. Duarte L.P. Ruaro T.C. Zimmer A.R. Kulkamp-Guerreiro I.C. Contri R.V. Nanoemulsion containing kojic dipalmitate and rosehip oil: A promising formulation to treat melasma. Pharmaceutics 2023 15 2 468 10.3390/pharmaceutics15020468 36839792
    [Google Scholar]
  30. Lane M.E. Skin penetration enhancers. Int. J. Pharm. 2013 447 1-2 12 21 10.1016/j.ijpharm.2013.02.040 23462366
    [Google Scholar]
  31. Phatale V. Vaiphei K.K. Jha S. Patil D. Agrawal M. Alexander A. Overcoming skin barriers through advanced transdermal drug delivery approaches. J. Control. Release 2022 351 361 380 10.1016/j.jconrel.2022.09.025 36169040
    [Google Scholar]
  32. Krambeck K. Silva V. Silva R. Fernandes C. Cagide F. Borges F. Santos D. Otero-Espinar F. Lobo J.M.S. Amaral M.H. Design and characterization of nanostructured lipid carriers (NLC) and nanostructured lipid carrier-based hydrogels containing passiflora edulis seeds oil. Int. J. Pharm. 2021 600 120444 10.1016/j.ijpharm.2021.120444 33713760
    [Google Scholar]
  33. Saeedi M. Eslamifar M. Khezri K. Kojic acid applications in cosmetic and pharmaceutical preparations. Biomed. Pharmacother. 2019 110 582 593 10.1016/j.biopha.2018.12.006 30537675
    [Google Scholar]
  34. Teixeira R.S. Rocha P.R. Polonini H.C. Brandão M.A.F. Chaves M.G.A.M. Raposo N.R.B. Mushroom tyrosinase inhibitory activity and major fatty acid constituents of Amazonian native flora oils. Braz. J. Pharm. Sci. 2012 48 3 399 404 10.1590/S1984‑82502012000300006
    [Google Scholar]
  35. Ando H. Watabe H. Valencia J.C. Yasumoto K. Furumura M. Funasaka Y. Oka M. Ichihashi M. Hearing V.J. Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: A new aspect of ubiquitin-proteasome function. J. Biol. Chem. 2004 279 15 15427 15433 10.1074/jbc.M313701200 14739285
    [Google Scholar]
  36. Rabrenović B.B. Dimić E.B. Novaković M.M. Tešević V.V. Basić Z.N. The most important bioactive components of cold pressed oil from different pumpkin (Cucurbita pepo L.) seeds. Lebensm. Wiss. Technol. 2014 55 2 521 527 10.1016/j.lwt.2013.10.019
    [Google Scholar]
  37. Juhaimi F.A. Ghafoor K. Uslu N. Mohamed Ahmed I.A. Babiker E.E. Özcan M.M. Fadimu G.J. The effect of harvest times on bioactive properties and fatty acid compositions of prickly pear (Opuntia ficus-barbarica A. Berger) fruits. Food Chem. 2020 303 125387 10.1016/j.foodchem.2019.125387 31454759
    [Google Scholar]
  38. Lin Y.H. Nien C.J. Chen L.G. Lee S.Y. Chang W.J. Pan Y.H. Hsieh S.C. Huang H.M. Sapindus mukorossi seed oil changes tyrosinase activity of α-MSH-induced B16F10 cells via the antimelanogenesic effect of eicosenoic acid. Nat. Prod. Commun. 2020 15 11 1934578X20972295 10.1177/1934578X20972295
    [Google Scholar]
  39. Chaikul P. Lourith N. Kanlayavattanakul M. Antimelanogenesis and cellular antioxidant activities of rubber (Hevea brasiliensis) seed oil for cosmetics. Ind. Crops Prod. 2017 108 56 62 10.1016/j.indcrop.2017.06.009
    [Google Scholar]
  40. Chaikul P. Sripisut T. Chanpirom S. Sathirachawan K. Ditthawutthikul N. Melanogenesis inhibitory and antioxidant effects of Camellia oleifera seed oil. Adv. Pharm. Bull. 2017 7 3 473 477 10.15171/apb.2017.057 29071231
    [Google Scholar]
  41. Suzuki S. Fujisawa H. Abe J. Kimura K. Anti-melanogenesis activity of supercritical carbon dioxide extract from perilla frutescens seeds. Adv. Biol. Chem. 2023 13 1 42 55 10.4236/abc.2023.131004
    [Google Scholar]
  42. Ishii T. Shimizu T. Imai M. Healy J. Rouzard K. Tamura M. Fitzgerald C. Arctigenin-enriched burdock seed oil (ABSO): A new skin brightening botanical extract. Cosmetics 2023 10 1 10 10.3390/cosmetics10010010
    [Google Scholar]
  43. Cui H.X. Duan F.F. Jia S.S. Cheng F.R. Yuan K. Antioxidant and tyrosinase inhibitory activities of seed oils from Torreya grandis Fort. ex Lindl. BioMed Res. Int. 2018 2018 1 10 10.1155/2018/5314320 30320135
    [Google Scholar]
  44. Kothapalli L. Dhakane T. Bhosale K. Thomas A. Seed oils as tyrosinase inhibitors for the treatment of hyperpigmentation. Curr. Enzym. Inhib. 2024 20 2 124 131 10.2174/0115734080257150231017094342
    [Google Scholar]
  45. Athikomkulchai S. Tunit P. Tadtong S. Jantrawut P. Sommano S.R. Chittasupho C. Moringa oleifera seed oil formulation physical stability and chemical constituents for enhancing skin hydration and antioxidant activity. Cosmetics 2020 8 1 2 10.3390/cosmetics8010002
    [Google Scholar]
  46. Silva C.C. Benati R.B. Massaro T.N.C. Pereira K.C. Gaspar L.R. Marcato P.D. Antioxidant and anti-tyrosinase activities of quercetin-loaded olive oil nanoemulsion as potential formulation for skin hyperpigmentation. J. Dispers. Sci. Technol. 2023 44 14 2628 2638 10.1080/01932691.2022.2116715
    [Google Scholar]
  47. Cao L. Li X. Zhao J. Du Q. Dun J. Skin pigmentation improvement with resveratrol microemulsion gel using polyoxyethylene hydrogenated castor oil. Drug Dev. Ind. Pharm. 2023 49 2 207 216 10.1080/03639045.2023.2195508 36971611
    [Google Scholar]
  48. Domínguez-Oliva A. Hernández-Ávalos I. Martínez-Burnes J. Olmos-Hernández A. Verduzco-Mendoza A. Mota-Rojas D. The importance of animal models in biomedical research: Current insights and applications. Animals 2023 13 7 1223 10.3390/ani13071223 37048478
    [Google Scholar]
  49. Cortegiani A. Absalom A.R. Importance of proper conduct of clinical trials. Br. J. Anaesth. 2021 126 2 354 356 10.1016/j.bja.2020.09.030 33121749
    [Google Scholar]
  50. Parvizi M.M. Saki N. Samimi S. Radanfer R. Shahrizi M.M. Zarshenas M.M. Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial. J. Cosmet. Dermatol. 2024 23 3 911 917 10.1111/jocd.16056 37927123
    [Google Scholar]
  51. Shah S. Chew S.K. Efficacy and safety of topical depigmenting agent in healthy human fair skin female volunteers: A single‐arm study. J. Cosmet. Dermatol. 2018 17 5 830 839 10.1111/jocd.12435 29193788
    [Google Scholar]
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Vegetable Oils in Skin Whitening - A Narrative Review
Bentham Science Publishers ; https://doi.org/10.2174/0113816128361413250107114203
/content/journals/cpd/10.2174/0113816128361413250107114203
/content/journals/cpd/10.2174/0113816128361413250107114203
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  • Article Type:     Review Article
Keywords: Vegetable oils ; depigmenting ; chemical analysis ; skin whitening ; formulation ; skin barrier

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